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Researchers find protein that silences genes

nges in histone modification".

Pikaard's other collaborators, all experts in microscopy, are researchers from the Instituto Superior de Agronomia, Tapada da Ajuda, in Lisbon, Portugal, and the Universidade Nova de Lisboa, Monte da Caparica, Caparica, Portugal. The work was supported by the National Institutes of Health and the National Science Foundation as well as the Fundação para a Ciência e Tecnologia, Portugal.

Pikaard's ultimate direction is to find out what makes the cell decide which set of ribosomal genes to silence.

"We understand better how the silencing is happening, but we don't know how the choice is made," Pikaard said. "Another thing we want to know is how all these activities for histone modification and DNA methylation are working together. At some point the various proteins must be interacting. The long term goal, though, is finding the choice mechanism."


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Source:Washington University in St. Louis


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