Navigation Links
Researchers find promising cancer-fighting power of synthetic cell-signaling molecule

Liotta and his colleagues at Emory prepared almost 100 sphingolipid-based analogs that lead to the discovery that the Enigmols were the most potent. The lead compounds were named "Enigmols" because sphingolipids were named after the sphinx for their enigmatic properties. Emory University holds the patent on compounds of this type.

In addition to being more potent than naturally occurring sphingolipids, the researchers have also found that Enigmols can be administered orally and appear in often-difficult-to reach organs such as the prostate. "This is what suggested to us that Enigmols should be tested against other cancer types," Merrill explained.

Subsequently, the researchers found that Enigmols suppress the growth of human prostate tumors implanted in mice, which is a commonly used model to test new anti-cancer drugs. They were also effective in two other mouse models for colon cancer.

"We do not know why Enigmols affect such a wide range of tumor cell types," Merrill said. "But it may be due to the involvement of sphingolipids in multiple cell-signaling pathways. This means a compound may affect several different targets, rather than just one."

In essence, Enigmols may act like a multi-drug combination therapy, the investigators speculate.

Enigmols are also being tested in combination with other cancer chemotherapeutic drugs using funds from EmTech Bio -- a life sciences technology business incubator operated by Georgia Tech and Emory. This research is coordinated with Slainte Bioceuticals, a start-up biotechnology company in metro Atlanta that is helping to bring this potential drug to market.

"Even if Enigmols are effective in humans, the greatest success is likely to come from the right combination of drugs that interact in a synergistic way," Merrill noted. So information from the EmTech Bio study may be particularly useful if Enigmols enter human clinical trials because the patients will have undergone, and wil
'"/>

Source:Georgia Institute of Technology Research News


Page: 1 2 3

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. Researchers reveal the infectious impact of salmon farms on wild salmon
5. Researchers identify target for cancer drugs
6. Researchers discover molecule that causes secondary stroke
7. Researchers find missing genes of ancient organism
8. Researchers trace evolution to relatively simple genetic changes
9. Researchers add new tool to tumor-treatment arsenal
10. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
11. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
Post Your Comments:
(Date:6/30/2015)... Genisphere announced Tom Bliss ... further develop Genisphere,s therapeutics capabilities and portfolio. Mr. Bliss ... much of the last 25 years in leadership positions ... Johnson & Johnson. Tom started his career in Investment ... Finance. He graduated from Dartmouth College with a BA ...
(Date:6/26/2015)... Utah , June 26, 2015 ATL Technology, ... and devices with specialties in single use solutions, headquartered in ... of MedConx, Inc. (a California corporation ... and San Jose, Costa Rica ). ... Costa Rica with ATL Technology,s existing facility ...
(Date:6/25/2015)... SALT LAKE CITY , June 25, 2015 /PRNewswire/ ... the first steps toward a healthier, happier life. That,s ... app is designed to do. The cutting-edge, portable health ... and offers real-life solutions to help improve your lifestyle ... Sellers Association awards dinner and gala Wednesday night, USANA,s ...
Breaking Biology News(10 mins):Genisphere Appoints New CEO, Thomas Bliss 2Genisphere Appoints New CEO, Thomas Bliss 3ATL Technology Announces Acquisition of MedConx, Inc. and Expanded Global Footprint 2@USANAinc's Personalized Nutrition Program Wins Industry Innovation Award 2
... at St. Jude Children,s Research Hospital have identified inherited variations ... acute lymphoblastic leukemia (ALL), including a gene that may help ... complete search of the human genetic blueprint or genome to ... childhood cancer. Published in the August 16 advance online issue ...
... at the Keck School of Medicine of the University ... mechanism that may govern an individual,s risk of developing ... Public Library of Science (PLoS) Genetics journal, ... no genes are present (gene ,deserts,) at a chromosomal ...
... at WPTRC is as diverse as the agencies that fund ... and studying the ecosystems of the island and the region. ... urging his,faculty to find new sources of external funds, and ... funding agencies that are now supporting the WPTRC and its ...
Cached Biology News:Inherited risk factors increase odds of developing childhood acute lymphoblastic leukemia 2Inherited risk factors increase odds of developing childhood acute lymphoblastic leukemia 3UOG scientists successfully compete for research grants 2
(Date:7/31/2015)... Dallas, Texas (PRWEB) , ... July 31, 2015 ... ... research report, offering competitive market analysis and premium industry insights on the global ... challenges, based on a collective study of vivid market scenarios and analysis of ...
(Date:7/31/2015)... ... July 31, 2015 , ... R-Biopharm is proud to announce ... gluten in foods, has been accepted by AOAC International as Official First Action ... Fermented Cereal-Based Products by R5 Competitive ELISA,” based on a specific monoclonal antibody ...
(Date:7/30/2015)... 2015 AACC welcomed thousands of medical ... Annual Meeting & Clinical Lab Expo in ... meeting showcased revolutionary advancements in clinical testing technology ... providers to diagnose patients quickly and accurately and ... As of Wednesday, July 29, more ...
(Date:7/30/2015)... ... July 30, 2015 , ... Tronics, a ... Sales & Marketing Director. , With more than 25 years of experience ... reinforcing Tronics’ business development activities worldwide. He brings to the company his strong ...
Breaking Biology Technology:Resorcinol Market to Grow at 6% CAGR to 2019 Says New Research Report at ReportsnReports.com 2Resorcinol Market to Grow at 6% CAGR to 2019 Says New Research Report at ReportsnReports.com 3Resorcinol Market to Grow at 6% CAGR to 2019 Says New Research Report at ReportsnReports.com 4RIDASCREEN® Competitve Gliadin Receives AOAC Official First Action Status 2Innovative Research on Cancer, Heart Disease, and Infectious Diseases Draws More than 17,500 Attendees to 2015 AACC Annual Meeting 2Innovative Research on Cancer, Heart Disease, and Infectious Diseases Draws More than 17,500 Attendees to 2015 AACC Annual Meeting 3Innovative Research on Cancer, Heart Disease, and Infectious Diseases Draws More than 17,500 Attendees to 2015 AACC Annual Meeting 4Tronics appoints Francois Vieillard as Sales and Marketing Director 2
... known as eosinophils have a central role in causing ... Hospital, Boston, has developed approaches to noninvasively visualize in ... mice with a disease that mimics asthma (experimental allergic ... developed to help assess the efficacy of treatments (both ...
... Ticket Software LLC as State,s,Fastest Growing Technology Company, ... Technology,Council and the accounting firm UHY LLP feted ... night at the Chevrolet Theater in,Wallingford. The list ... and included such well known brands as Priceline.com ...
... (Nasdaq: MEMY ) today announced that Michael Smith, ... a company update at,the Rodman & Renshaw Annual Global ... EST at the New York Palace Hotel, in New,York ... of the presentation by,visiting the "Investors" section of Memory ...
Cached Biology Technology:Connecticut Technology Council Honors UHY LLP Tech Top 40 Winners 2Connecticut Technology Council Honors UHY LLP Tech Top 40 Winners 3Connecticut Technology Council Honors UHY LLP Tech Top 40 Winners 4
Request Info...
Please email us with project details and we will respond within 24 hours to your query!...
Makes gels easy to load and track during electrophoresis. 10X concentrate of Bromophenol Blue, glycerol solution....
Request Info...
Biology Products: