Navigation Links
Researchers find new genes necessary to make embryo

Researchers at New York University and the medical schools at Harvard and Yale universities have identified new genes necessary for embryonic development, according to findings published in the latest issue of Genome Research. This discovery is an important step toward a complete mapping of which parts of the genome are required for embryonic development. The new findings also probe into how genetic networks are built and how they could evolve.

The team, headed by biologists at NYU, is studying the genome of the Caenorhabditis elegans (C. elegans), the first animal species whose genome was completely sequenced and a model organism to study how embryos develop. Using RNA interference (RNAi), a method for identifying the function of genes, the researchers almost double previous estimates of how many genes are required to make an embryo. Their study focused on the genes expressed by the mother and imparted to the egg, ready to be used during the earliest stages after fertilization. They discovered over 150 additional genes required to make an embryo beyond what was previously known, leading them to conclude that many more genes will be found in the future. The researchers estimate that at least 2,600 genes are required for embryonic development in C. elegans, of which about 70% are currently known.

The majority of genes required for embryogenesis in C. elegans have counterparts in humans whose roles are often unknown. For example, human counterparts of four of the newly identified genes are known to be associated somehow with disease, and mutations in two of these are associated with tumors. The C. elegans study suggests specific cellular roles for these genes, thus providing important clues to how these genes work in humans.

The new data also asked allowed the researchers to have a first genome-wide look at a classic genetic phenomenon called "partial penetrance" ?whereby the same genetic mutations may elicit different results in different indiv iduals.

"The results from the analyses of genes showing partial penetrance suggest the possibility of a general architectural motif in genetic networks," said Fabio Piano, an NYU biologist and lead author of the study, "in which genes in critical positions consist largely of older components while new functions added later provide additional layers of regulation to lend adaptive functions to these core networks."


'"/>

Source:New York University


Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. Researchers reveal the infectious impact of salmon farms on wild salmon
5. Researchers identify target for cancer drugs
6. Researchers discover molecule that causes secondary stroke
7. Researchers find missing genes of ancient organism
8. Researchers trace evolution to relatively simple genetic changes
9. Researchers add new tool to tumor-treatment arsenal
10. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
11. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/29/2017)... the health IT company that operates the largest health ... today announced a Series B investment from BlueCross BlueShield ... investment and acquisition accelerates higi,s strategy to create the ... activities through the collection and workflow integration of ambient ... secures data today on behalf of over 36 million ...
(Date:3/27/2017)... 2017  Catholic Health Services (CHS) has been ... (HIMSS) Analytics for achieving Stage 6 on the ... In addition, CHS previously earned a place in ... electronic medical record (EMR). "HIMSS Analytics ... EMR usage in an outpatient setting.  This recognition ...
(Date:3/24/2017)... Research and Markets has announced the addition of the "Global ... to 2025" report to their offering. ... The Global Biometric Vehicle Access System Market ... the next decade to reach approximately $1,580 million by 2025. ... for all the given segments on global as well as regional ...
Breaking Biology News(10 mins):
(Date:8/15/2017)... , ... August 15, 2017 , ... ... family of 6” modular downlights designed to stay tightly sealed and perform efficiently ... where damp and wet location listings just aren't enough, such as: hospitals; behavioral ...
(Date:8/14/2017)... , ... August 14, 2017 , ... ... and performing antibodies. Key researchers in the antibody community have recently come together ... consistency for antibodies in the laboratory. , The team at ...
(Date:8/11/2017)... ... , ... A staple in the community for more than 60 years, Bill ... including a new digital marketing strategy and updated logo. , As part of the ... with the South Texas Blood & Tissue Center for the month of August. ...
(Date:8/10/2017)... , ... August 09, 2017 , ... ... classroom next week-- as students. From August 14th through the 16th, the University ... which debuted in the summer of 2016, provides Philadelphia-based middle school educators an ...
Breaking Biology Technology: