Navigation Links
Researchers find missing genes of ancient organism

Yale scientists report in the journal Nature that the "missing" genes for tRNA in an ancient parasite are made up by splicing together sequences in distant parts of the DNA genome.

The research led by Professor Dieter Söll in the Department of Molecular Biophysics and Biochemistry at Yale focuses on the most ancient organism with a known genome sequence. Nanoarchaeum equitans, is a member of a new phylogenetic kingdom in the Archaea containing organisms that are primitive, parasitic and extremophile, or notable for living in the most extreme environments.

Surprisingly, Söll's team found that, although the genome of Nanoarchaeum lacks several intact tRNA genes, functional forms of those tRNAs can be made by copying from two distant DNA sequences -- and joining them.

The regions on the separate pieces, that allow them to find each other and splice, are somewhat similar to internal sequences found in tRNA genes of more complex organisms., These regions, termed introns, are sequences that are cut out of whole gene transcripts during the process of tRNA maturation. The known tRNA introns in organisms like yeast, however, appear to have no function. Therefore, modern tRNA introns might be remnants of an old essential process of tRNA biosynthesis.

"These results may point to extremophiles in the kingdom of Archaea as predecessors of more modern organisms that have gained a genetic load in the process of evolution," said Söll. "Or they may represent a specialization that has rid itself of genetic baggage to exist in extreme environments."

Understanding how primitive organisms like Nanoarchaea operate gives clues to -- but not proof of -- the relationship between modern and ancient organisms.

###

Other authors on the paper include Lennart Randau and Michael J. Hohn from Yale, and Richard Münch and Dieter Jahn from the Technical University Braunschweig, Germany. This work was supported by grants from the National Institut e of General Medical Sciences, the Department of Energy, and the German Federal Ministry of Education and Research (BMBF).

Citation: Nature 433: 537-541 (February 3, 2005)
Supplementary material: http://www.prodoric.de/sts/


'"/>

Source:Yale University


Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. Researchers reveal the infectious impact of salmon farms on wild salmon
5. Researchers identify target for cancer drugs
6. Researchers discover molecule that causes secondary stroke
7. Researchers trace evolution to relatively simple genetic changes
8. Researchers add new tool to tumor-treatment arsenal
9. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
10. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
11. Researchers develop rapid diagnostic tool for pathogen identification
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/14/2020)... ... February 14, 2020 , ... Trial By Fire Solutions, ... and Payment tracking, will be showcasing SimpleTrials at the Summit For Clinical Ops ... SCOPE Summit last year, the SimpleTrials team has completed full validation of the ...
(Date:2/13/2020)... ... 13, 2020 , ... Strategic Directions International (SDi) announced today ... Life Science Instrumentation Industry. The report will be released on February 28th. The ... the $70 billion laboratory market for analytical and life science instruments. Special offers ...
(Date:2/13/2020)... ... February 13, 2020 , ... Worldwide Business with kathy ... CEO Yoram Ashery to discuss how their revolutionary technology can kill bacteria and ... keep people healthy with their revolutionary nanoparticle technology. Nobio is on the cutting ...
Breaking Biology News(10 mins):
(Date:2/11/2020)... ... February 11, 2020 , ... Synagro Technologies, ... America, today announced that the City of Fort Worth has partnered with Synagro ... Commencing in April of 2020, Synagro will assume operation of the city’s current ...
(Date:2/5/2020)... , ... February 04, 2020 , ... ... for characterizing microbiome populations down to the strain level, has announced a new ... Shoreline Biome’s microbiome kits and other products to companies and research organizations in ...
(Date:2/3/2020)... ... February 03, 2020 , ... Ovation Travel Group ... Technology Industry Travel and Biotech/Healthcare Industry Travel Indexes. , All of the Indexes ... statistics:, Average airfare price paid Domestically, Internationally and ...
(Date:1/28/2020)... WORTH, Texas (PRWEB) , ... January 28, 2020 ... ... Scientific to be the exclusive distributor to food and beverage manufactures within ... and are considered critical suppliers. This agreement will allow each company to pool ...
Breaking Biology Technology: