Navigation Links
Researchers find missing genes of ancient organism

Yale scientists report in the journal Nature that the "missing" genes for tRNA in an ancient parasite are made up by splicing together sequences in distant parts of the DNA genome.

The research led by Professor Dieter Söll in the Department of Molecular Biophysics and Biochemistry at Yale focuses on the most ancient organism with a known genome sequence. Nanoarchaeum equitans, is a member of a new phylogenetic kingdom in the Archaea containing organisms that are primitive, parasitic and extremophile, or notable for living in the most extreme environments.

Surprisingly, Söll's team found that, although the genome of Nanoarchaeum lacks several intact tRNA genes, functional forms of those tRNAs can be made by copying from two distant DNA sequences -- and joining them.

The regions on the separate pieces, that allow them to find each other and splice, are somewhat similar to internal sequences found in tRNA genes of more complex organisms., These regions, termed introns, are sequences that are cut out of whole gene transcripts during the process of tRNA maturation. The known tRNA introns in organisms like yeast, however, appear to have no function. Therefore, modern tRNA introns might be remnants of an old essential process of tRNA biosynthesis.

"These results may point to extremophiles in the kingdom of Archaea as predecessors of more modern organisms that have gained a genetic load in the process of evolution," said Söll. "Or they may represent a specialization that has rid itself of genetic baggage to exist in extreme environments."

Understanding how primitive organisms like Nanoarchaea operate gives clues to -- but not proof of -- the relationship between modern and ancient organisms.

###

Other authors on the paper include Lennart Randau and Michael J. Hohn from Yale, and Richard Münch and Dieter Jahn from the Technical University Braunschweig, Germany. This work was supported by grants from the National Institut e of General Medical Sciences, the Department of Energy, and the German Federal Ministry of Education and Research (BMBF).

Citation: Nature 433: 537-541 (February 3, 2005)
Supplementary material: http://www.prodoric.de/sts/


'"/>

Source:Yale University


Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. Researchers reveal the infectious impact of salmon farms on wild salmon
5. Researchers identify target for cancer drugs
6. Researchers discover molecule that causes secondary stroke
7. Researchers trace evolution to relatively simple genetic changes
8. Researchers add new tool to tumor-treatment arsenal
9. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
10. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
11. Researchers develop rapid diagnostic tool for pathogen identification
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology: