Researchers find how some antibiotics kill bacteria ( polymerase's molecular 'hood' we could...)

Researchers find how some antibiotics kill bacteria

polymerase's molecular 'hood' we couldn't see what the problem was," she said. "We never suspected that removing this ion was what killed rifamycin-sensitive bacteria. But the resolution of previous atomic structures wasn't sufficient enough to see that."

The higher-resolution images also showed that rifapentin and rifabutin each bind just a little differently to E. coli, but still bring about the same results.

The answer to creating a new breed of bacteria-resistant antibiotics may lie in these variations in binding.

"From these findings we can suggest how rifamycins that are currently used in therapy can be improved to be effective even against existing resistant strains of bacteria," Artsimovitch said

Rifamycins are what drug companies call "broad-spectrum antibiotics." Not only are they effective against tuberculosis, they also act against a variety of other pathogens including Neisseria meningitidis, the bacterium that causes one form of meningitis; Helicobacter pylori, which causes stomach ulcers; and even some parasitic worms by eliminating the symbiotic bacteria parasites depend on.

"It's the kind of drug the pharmaceutical business wants to produce," Artsimovitch said. "They're looking for the broadest range of antibiotics possible. Rifamycins would be ideal drugs if we could figure out how to get rid of resistance."

Source:Ohio State University

Page: 1 2 3
Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. Researchers reveal the infectious impact of salmon farms on wild salmon
5. Researchers identify target for cancer drugs
6. Researchers discover molecule that causes secondary stroke
7. Researchers find missing genes of ancient organism
8. Researchers trace evolution to relatively simple genetic changes
9. Researchers add new tool to tumor-treatment arsenal
10. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
11. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain

Post Your Comments:

(Date:6/19/2013)... provider of scientific, technical and medical information products and ... new open access journal, GeoResJ . , ... and planetary science journals portfolio has its first open ... forum for rapid publication of top research within the ... by six Executive Editors, each covering a different discipline, ...

(Date:6/18/2013)... UT Arlington environmental engineer has been awarded a ... to ensure water quality and flow in the ... , Andrew Kruzic, UT Arlington associate professor of ... locations to add monochloramine to the water in ... new pump stations and pipelines. Adding monochloramine is ...

(Date:6/18/2013)... $12.7 million to match nine academic research groups ... explore new treatments for patients in eight disease ... schizophrenia. The collaborative pilot initiative, called Discovering New ... the National Center for Advancing Translational Sciences (NCATS) ... The process of developing a new therapeutic is ...

Breaking Biology News(10 mins):UT Arlington research to benefit quality, flow in 150-mile Integrated Pipeline 2 NIH to fund collaborations with industry to identify new uses for existing compounds 2 NIH to fund collaborations with industry to identify new uses for existing compounds 3 NIH to fund collaborations with industry to identify new uses for existing compounds 4

[0] Elsevier launches open access journal: GeoResJ [0] UT Arlington research to benefit quality, flow in 150-mile Integrated Pipeline [0] NIH to fund collaborations with industry to identify new uses for existing compounds

... A Century of Change, literally took 100 years to write. ... from 1906-1909. It was repeated from 1956-1958 and a technical ... anniversary of that first survey was approaching, ornithologists Mike Ward, ... of opportunity to do it again and write a book, ...

... the United States and Japan analyzed fossil evidence found ... horned dinosaur. The newly identified genus, Koreaceratops ... the late Early Cretaceous period. The specimen is ... The partial skeleton includes a significant portion of the ...

... social stress activates the immune system and accelerates the ... pressure, however, may stop this process. This is the ... Gothenburg, Sweden. Several large studies have clearly shown ... the risk of developing cardiovascular disease. However, little is ...

Cached Biology News:New book on 100 years of Illinois birds 2 New book on 100 years of Illinois birds 3 New book on 100 years of Illinois birds 4 Scientists announce discovery of first horned dinosaur from South Korea 2 Social stress leads to atherosclerosis 2

New book on 100 years of Illinois birds Scientists announce discovery of first horned dinosaur from South Korea Social stress leads to atherosclerosis

(Date:6/19/2013)... , June 19, 2013 Biotechnology industry pioneer ... up with financial software provider BlackLine Systems and ... SAP ) for a webinar next week entitled ... Solutions from BlackLine and SAP to Help Keep Its Account ... http://photos.prnewswire.com/prnh/20061117/LAF027LOGO ) The webinar, geared at ...

(Date:6/19/2013)... A new look at “big glass” and ... will highlight technical sessions at SPIE Photomask Technology ... 33rd year, the three-day event is the industry’s largest ... approximately 100 technical presentations and numerous networking lunches and ... optics and photonics , the meeting will be held ...

(Date:6/18/2013)... HONG KONG, June 18, 2013 China Cord ... the "Company"), China,s leading provider of cord blood collection, ... storage services, today announced its preliminary unaudited financial results ... year 2013 ended March 31, 2013. ... for the fourth quarter of fiscal 2013 increased by ...

(Date:6/18/2013)... 18, 2013 The human skin is the ... an important human body part. Similar to the liver, or ... to function, repair and grow. Recent reports from the mankatofreepress.com ... is just as important as other life supporting organs. The ... in skin cell reproduction, increase the appearance of skin, and ...

[0] Amgen Joins BlackLine Systems, SAP for Webinar on Automating Account Reconciliations [0] ‘Big Glass’ and Visions for the Future are on the Program for SPIE Photomask Technology [0] China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 [0] Natural Acne Remedies Through Diet, Probiotic Action Shares New Insight on What Foods May Help Lead to Clear Skin

... Jan. 4, 2011 Advanced Life Sciences Holdings, ... a biopharmaceutical company engaged in the discovery, development and ... infection, oncology and respiratory diseases, today announced that it ... Conference held January 10-12th in San Francisco. ...

... a biological weapon so specific, it can target an individual ... seeds of death are sown into the very blueprints of ... of us, buried deep within the human genetic code. How ... diseases? Doug Flanders ponders these very questions in ...

... Jan. 4, 2011 Reportlinker.com announces ... is available in its catalogue: ... Market: DNA Probes and Biochips New ... Strategies for Instrument and Reagent Suppliers ...

Cached Biology Technology:Advanced Life Sciences to Present at the Biotech Showcase™ 2011 Conference 2 James Bond Meets Cheaper by the Dozen: An Action Thriller the Entire Family Will Enjoy 2 Reportlinker Adds The 2011 Molecular Diagnostics Market: DNA Probes and Biochips New Product Development Opportunities and Business Expansion Strategies for Instrument and Reagent Suppliers 2

Advanced Life Sciences to Present at the Biotech Showcase™ 2011 Conference James Bond Meets Cheaper by the Dozen: An Action Thriller the Entire Family Will Enjoy Reportlinker Adds The 2011 Molecular Diagnostics Market: DNA Probes and Biochips New Product Development Opportunities and Business Expansion Strategies for Instrument and Reagent Suppliers

...

UltraPure DNase/RNase-Free Distilled Water is designed for use in all molecular biology applications. It is 0.1-m membrane-filtered and tested for DNase and RNase activity....

...

Water Distilled (Gibco™) is membrane filtered and endotoxin screened....

Biology Products:

Polyvalent HRP AEC Detection System from Spring Bioscience UltraPure DNase/RNase-Free Distilled Water from Invitrogen Luminex 100 IS System from Luminex Corporation GIBCO Water distilled from Invitrogen