Navigation Links
Researchers find cause of frontotemporal dementia

Frontotemporal Dementia (FTD) is the second major form of dementia. Under the direction of Christine Van Broeckhoven, researchers from the Flanders Interuniversity Institute for Biotechnology (VIB) affiliated to the University of Antwerp have recently discovered that the progranulin growth factor plays an important biological role in the development of this form of dementia. Because progranulin is known primarily for its role in tumor formation, this research result is very surprising. Although progranulin's proper role in the brain is not yet known, it may well be responsible for the survival of brain cells, because FTD patients have a shortage of this growth factor. The new finding predicts that progranulin might also play a role in other types of brain diseases in which brain cells die off ?such as Alzheimer's disease and Parkinson's disease.

Frontotemporal dementia
After Alzheimer's, frontotemporal dementia is the most prevalent form of dementia in patients younger than 65. FTD affects the frontal lobe, causing the brain tissue to die off. The frontal lobe is the foremost part of the brain and accounts for about 30% of the brain's mass. Among other things, the frontal lobe is involved in regulating behavior, movement and mood, and is responsible for cognitive functions like memory and speech. So, FTD is clinically characterized by changes in personality and, in a later stage, loss of cognitive functions.

Looking for the needle in the haystack
Genetic research has previously shown that FTD is caused by a defect in chromosome 17. Chromosome 17 is the carrier of the tau protein's hereditary code, and defects in this protein cause tau-positive FTD. However, there is another form of FTD that occurs much more frequently than tau-positive FTD ?namely, ubiquitin-positive FTD (FTDU). Patients with FTDU do not have a defect in the tau protein, but in another protein in chromosome 17. Christine Van Broeckhoven's research team has now i dentified this protein: progranulin. In order to substantiate this discovery, the group worked intensively with neurologists from university memory clinics in Antwerp, Leuven, and Ghent. Genetic analyses of the DNA from FTDU families identifies defects that cause a shortage of progranulin. Progranulin is known in cancer research, where a surplus of this protein leads to tumors. What it does in the brain, and how it supports brain cells, is not yet known.

An unexpected turn
The biological role of progranulin in the formation of FTD provides a totally new insight into how brain cells die off. Van Broeckhoven's team's research indicates that the quantity of progranulin in the brain is important for the brain cells' survival. The hereditary defects that the researchers have found in FTD patients cause only 50% of the protein to be produced, because only one copy of the gene is active. Therefore, FTD patients produce less progranulin than healthy individuals. It has already been shown that too much progranulin leads to cancer ?now, these researchers are revealing that too little progranulin underlies FTD.

New diagnostic and therapeutic possibilities
This discovery does not directly result in a new remedy for FTD patients ?a lot more research is needed for that. But this finding does offer the prospect of a new treatment for FTD and possibly also for other diseases of the brain that entail the dying off of brain cells ?like Alzheimer's disease as well as Parkinson's disease. Given that a deficiency of progranulin leads to FTD, administration of this protein could offer a simple solution. However, the trick will be to administer the right quantity, because too much progranulin leads to the formation of tumors. A fine line to navigate! Thanks to this finding, though, upon a doctor's request, a genetic study can be done on FTD patients and their family members if they so desire.


'"/>

Source:VIB, Flanders Interuniversity Institute of Biotechnology


Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. Researchers reveal the infectious impact of salmon farms on wild salmon
5. Researchers identify target for cancer drugs
6. Researchers discover molecule that causes secondary stroke
7. Researchers find missing genes of ancient organism
8. Researchers trace evolution to relatively simple genetic changes
9. Researchers add new tool to tumor-treatment arsenal
10. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
11. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/28/2017)... , March 28, 2017 The ... Hardware (Camera, Monitors, Servers, Storage Devices), Software (Video Analytics, ... Region - Global Forecast to 2022", published by MarketsandMarkets, ... 2016 and is projected to reach USD 75.64 Billion ... and 2022. The base year considered for the study ...
(Date:3/24/2017)... 24, 2017 The Controller General of Immigration from ... Abdulla Algeen have received the prestigious international IAIR Award for the ... Continue Reading ... ... Controller Abdulla Algeen (small picture on the right) have received the IAIR ...
(Date:3/23/2017)... The report "Gesture Recognition and Touchless Sensing Market by Technology (Touch-based ... to 2022", published by MarketsandMarkets, the market is expected to be worth USD ... 2022. Continue Reading ... ... ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... and LAGUNA HILLS, Calif. , Oct. ... Cancer Research, London (ICR) and University ... SKY92, SkylineDx,s prognostic tool to risk-stratify patients with multiple myeloma ... MUK nine . The University of Leeds ... partly funded by Myeloma UK, and ICR will perform the ...
(Date:10/10/2017)... ... 2017 , ... San Diego-based team building and cooking events company, Lajollacooks4u, has ... The bold new look is part of a transformation to increase awareness, appeal to ... period. , It will also expand its service offering from its signature gourmet cooking ...
(Date:10/10/2017)... 10, 2017 International research firm Parks Associates announced ... at the TMA 2017 Annual Meeting , October 11 in ... residential home security market and how smart safety and security products impact ... Parks Associates: Smart Home ... "The residential security market has ...
(Date:10/9/2017)... DIEGO , Oct. 9, 2017  BioTech ... biological mechanism by which its ProCell stem cell ... critical limb ischemia.  The Company, demonstrated that treatment ... amount of limbs saved as compared to standard ... the molecule HGF resulted in reduction of therapeutic ...
Breaking Biology Technology: