Navigation Links
Researchers discover new form of cancer gene regulation

The Quaking gene, first described as a mutation in mice that causes rapid tremor, is thought to suppress tumor formation and protect humans from cancer.

Now, a team of researchers from Northwestern University and the University of Wisconsin has shown that the Quaking gene likely suppresses tumor growth by inhibiting production of a protein associated with GLI1, a cancer-causing oncogene highly associated with severe birth defects and several childhood cancers.

The group's study, published in the Nov. 1 online issue of Developmental Biology, details the discovery of an important and completely novel form of regulation of the GLI1 gene.

"Results of the study open a new research direction for issues ranging from cancer formation to environmental interactions in development and will point the way to similar mechanisms of control in other genes," said Philip M. Iannaccone, M.D., who led the study.

Iannaccone is George M. Eisenberg Professor of Pediatrics at Northwestern University Feinberg School of Medicine and deputy director for basic research at Children's Memorial Research Center.

Development occurs as a coordinated series of genetic control events that create proliferation of cells, signals for further differentiation, proteins that define cellular function and "programmed" movement of cells into developing structures.

These processes, known as pattern formation, are controlled largely by networks of genes and proteins called signal transduction pathways that receive signals from outside of the cell in the form of protein interaction with the cell surface. Through a series of intracellular events, these signals trigger gene activation or repression through action of transcription factors in the nucleus of the cell.

The altered gene expression profile then results in cellular differentiation, cellular proliferation or cellular death as pattern formation proceeds.

An important signal transduction pa
'"/>

Source:Northwestern University


Page: 1 2 3

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. Researchers reveal the infectious impact of salmon farms on wild salmon
5. Researchers identify target for cancer drugs
6. Researchers discover molecule that causes secondary stroke
7. Researchers find missing genes of ancient organism
8. Researchers trace evolution to relatively simple genetic changes
9. Researchers add new tool to tumor-treatment arsenal
10. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
11. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Researchers discover new form cancer gene regulation

(Date:8/20/2014)... 4,000 members, it triggers an important first stage in ... of comb used for rearing male reproductive, called drones. ... and Behaviour at Cornell University, led by Michael Smith, ... The results are published in Springer,s journal Naturwissenschaften ... isn,t always a honeybee colony,s top priority. Early ...
(Date:8/19/2014)... China,s increasing caesarean section rate, suggests a new commentary ... Journal of Obstetrics and Gynaecology (BJOG) . , China ... the world. Of 16 million babies born in 2010, ... is not known, the current Chinese language literature on ... from 36% to 58%. However, before the 1980s, the ...
(Date:8/19/2014)... It,s not a monkey. It,s not a lemur. It,s not ... the Philippine tarsier: a tiny, adorable and downright "cool" primate ... that Americans are familiar with," said Rafe Brown, curator-in-charge at ... eyes and ears; an extremely cute, furry body; a long ... expanded fingers and toe tips that look a bit like ...
Breaking Biology News(10 mins):Worker bees 'know' when to invest in their reproductive future 2Is China's 50 percent cesarean section delivery rate too high? 2Is China's 50 percent cesarean section delivery rate too high? 3Philippine tarsier gets boost from Kansas research, and genetic proof of a new variety 2Philippine tarsier gets boost from Kansas research, and genetic proof of a new variety 3
... know Edward Teller as the "Father of the H-Bomb." To his ... detractors he was evil personified. Between these extremes was the life ... well researched attempt to interpret the enigmatic nature of a great ... beliefs," says G. A. Keyworth, II, science advisor to President Reagan, ...
... LAFAYETTE, Ind. - Greenhouse plant growers can substitute rice ... for an increase in growth regulators, according to a ... often consists of a soilless mix of peat and ... also regularly use plant-growth regulators to ensure consistent and ...
... Laxenburg, Austria 26th October 2010 --,A new assessment ... warming cautions that unless current imbalances in R&D portfolios ... technologies are redressed, greenhouse gas (GHG) emission reduction targets ... considerable costs. The study identifies energy efficiency as ...
Cached Biology News:'Judging Edward Teller' 2'Judging Edward Teller' 3Rice hulls a sustainable drainage option for greenhouse growers 2Changes in energy R&D needed to combat climate change 2Changes in energy R&D needed to combat climate change 3
(Date:8/20/2014)... , Aug. 20, 2014  PAREXEL International Corporation ... will be presenting at the Baird Healthcare Conference in ... and Chief Financial Officer, will be making a presentation ... EDT on Wednesday, Sept. 3, 2014. A ... the "Investors" section of PAREXEL,s website at www.PAREXEL.com ...
(Date:8/20/2014)... Aug. 20, 2014 /PRNewswire-iReach/ -- A case study ... between the school,s bioengineering department and the Intel® ... Intel® Software Academic Program, UCSD,s research focuses on ... human body.  Photo - ... the work of Dr. Todd P. Coleman ...
(Date:8/20/2014)... 20, 2014 GraphDB™ 6.0 ... including improvements to the enterprise replication cluster, faster ... Lucene, SOLR and Elasticsearch. This release happens to ... performance triplestore – GraphDB™ was formerly known as ... the only mature enterprise resilient RDF triplestore will ...
(Date:8/19/2014)... Research and Markets  has announced the addition of the ... report to their offering. This report analyzes the ... by the following Product Segments: Media, Sera, and Reagents. ... Canada , Japan , Europe ... America . Annual estimates and forecasts are provided for the ...
Breaking Biology Technology:PAREXEL International To Present At Baird Healthcare Conference 2Intel and University of San Diego Bioengineering Department Release Case Study on Health Sciences Research 2Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 2Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 3Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 4Global Cell and Tissue Culture Supplies - Strategic Business Report 2014 2
... , ... Board: LTUS) ("Lotus" or the "Company") a growing developer ... pharmaceutical,products in the People,s Republic of China ("PRC"), today ... operating entity of Lotus,appointed Mr. Jinzhong HAN to be ...
... ... a multi-year, sole-source supply agreement with leading global dairy company Fonterra Co-operative Group Limited ... products for pregnant and nursing mothers. , ... Columbia, MD (Vocus) December 10, 2009 -- Martek Biosciences ...
... Collaboration to Create Optimized Antibodies Produces First Candidates Which ... Dec. 10 /PRNewswire-FirstCall/ - YM BioSciences Inc. (NYSE YMI, ... program between YM and the National Research Council ... IntelliMab(TM) technology, the program is designed to generate novel ...
Cached Biology Technology:Lotus Pharmaceuticals, Inc. Appoints OTC Division Head 2Lotus Pharmaceuticals, Inc. Appoints OTC Division Head 3Martek Signs Sole-Source Supply Agreement with Fonterra 2Martek Signs Sole-Source Supply Agreement with Fonterra 3YM BIOSCIENCES AND THE NATIONAL RESEARCH COUNCIL OF CANADA BIOTECHNOLOGY RESEARCH INSTITUTE (NRC-BRI) PRODUCE NEW BREAST CANCER DRUG CANDIDATES 2YM BIOSCIENCES AND THE NATIONAL RESEARCH COUNCIL OF CANADA BIOTECHNOLOGY RESEARCH INSTITUTE (NRC-BRI) PRODUCE NEW BREAST CANCER DRUG CANDIDATES 3YM BIOSCIENCES AND THE NATIONAL RESEARCH COUNCIL OF CANADA BIOTECHNOLOGY RESEARCH INSTITUTE (NRC-BRI) PRODUCE NEW BREAST CANCER DRUG CANDIDATES 4YM BIOSCIENCES AND THE NATIONAL RESEARCH COUNCIL OF CANADA BIOTECHNOLOGY RESEARCH INSTITUTE (NRC-BRI) PRODUCE NEW BREAST CANCER DRUG CANDIDATES 5
The Zymo-Spin PI Fast-Spin column features durable polypropylene construction and is the same column featured in the His-Spin Protein Miniprep. Capacity is 800 l....
LAL Chromogenic Endpoint assay...
...
Catch and Release® v2.0 Reversible Immunoprecipitation System...
Biology Products: