Navigation Links
Researchers discover molecule that causes secondary stroke

Scientists at the University of Cincinnati (UC) College of Medicine have discovered the cause of a deadly type of secondary stroke known as cerebral vasospasm.

A constriction of the blood vessels in the brain, cerebral vasospasm usually occurs three to 10 days following a massive brain bleed known as hemorrhagic stroke. Sixty percent of patients who survive the initial stroke develop vasospasm, and 40 percent of them die from it.

Vasospasm, says neurology department researcher Joseph Clark, PhD, results from a buildup of toxins caused by bleeding from the initial stroke. "Normally the cerebral spinal fluid that envelopes the brain carries off wastes and exchanges them for nutrients at what's called the blood-brain barrier," Dr. Clark says. "After a hemorrhagic stroke, however, toxins given off by the brain bleed contribute to the development of specific molecules that later causes the constricting vasospasm." A research team led by Dr. Clark has now identified the molecules that trigger vasospasm, a breakthrough, he says, that "raises hopes of developing not only new ways to treat the condition, but also a diagnostic test to determine which hemorrhagic stroke survivors are at greater risk."

Several spinal fluid components were suspected of causing the vasospasm, Dr. Clark explains. They included hemoglobin, bilirubin and peroxidized lipids, and a group of bilirubin oxidation products that the researchers called BOXes.

Building on Dr. Clark's earlier studies in rats, the team measured each of the suspect agents in 12 hemorrhagic stroke patients. Within 10 days, four of the group suffered a secondary cerebral vasospasm. The same patients were also found to have elevated levels of bilirubin and significantly higher levels of BOXes.

One of the 12 who had elevated bilirubin, but hardly any BOXes, did not experience a secondary stroke.

When bilirubin is elevated, says team member Gail Pyne-Geithman, PhD, it must be exposed to powerful oxidizers that cause the production of significant amounts of the BOXes. The correlation between elevated BOXes, bilirubin and oxidative stress in this study, she says, was "striking."

The researchers point out that although their findings are encouraging in terms of developing a diagnostic test and treatment, the number of patients in their study was small and more work is needed to confirm that vasospasm is more likely to occur in bleeding-stroke patients who have elevated levels of BOXes.


Source:University of Cincinnati

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. Researchers reveal the infectious impact of salmon farms on wild salmon
5. Researchers identify target for cancer drugs
6. Researchers find missing genes of ancient organism
7. Researchers trace evolution to relatively simple genetic changes
8. Researchers add new tool to tumor-treatment arsenal
9. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
10. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
11. Researchers develop rapid diagnostic tool for pathogen identification
Post Your Comments:

(Date:11/17/2015)... 2015 Paris from 17 ... Paris from 17 th until 19 ... innovation leader, has invented the first combined scanner in the ... same scanning surface. Until now two different scanners were required: one ... capture both on the same surface. This innovation is ...
(Date:11/16/2015)... , Nov 16, 2015  Synaptics Inc. (NASDAQ: ... interface solutions, today announced expansion of its TDDI ... touch controller and display driver integration (TDDI) ... smartphones. These new TDDI products add to the ... resolution), TD4302 (WQHD resolution), and TD4322 (FHD resolution) ...
(Date:11/11/2015)... , Nov. 11, 2015   MedNet Solutions , an ... of clinical research, is pleased to announce that it will ... Trials (PCT) event, to be held November 17-19 in ... to view live demonstrations of iMedNet , ... how iMedNet has been able to deliver time ...
Breaking Biology News(10 mins):
(Date:12/1/2015)... Minn. , Dec. 1, 2015  The Minnesota ... recipient of the 2015 Tekne Award in the Small ... at the Minneapolis Convention ... have played a significant role in developing new technologies ... living around the world. Clostridium difficile ...
(Date:12/1/2015)... ... 2015 , ... RURO, Inc., a leading LIMS, and other ... management software solution, ezColony®, is now available as a subscription-based, cloud-hosted software service. ... , Many organizations are moving to cloud-hosting for LIMS and other lab ...
(Date:12/1/2015)... , December 1, 2015 Dr. Harry Lander , President ... serving as Chief Science Officer and recruits five ... Harry Lander , President of Regen, expands his role to ... recruits five distinguished scientists to join advisory team ... expands his role to include serving as ...
(Date:11/30/2015)... (PRWEB) , ... November 30, 2015 , ... ... M.D., will join physicians, aesthetic practitioners and aesthetics professionals from Central America and ... to be held in Panama City, Panama Feb. 17-19, 2016. Testart will present ...
Breaking Biology Technology: