Navigation Links
Researchers discover mechanism for multiplying adult stem cells

While the field of human embryonic stem cell research receives a tremendous amount of public attention, many scientists are also exploring the potential of adult stem cells for possible therapies. But this field raises other difficulties. Although adult stem cell research isn't fraught with the controversies that surround embryonic stem cells, adult stem cells are extremely difficult to isolate and then to multiply in a lab dish. Now, as reported in the May 6 issue of the journal Cell, researchers in the lab of Whitehead Institute Member Rudolf Jaenisch have discovered a mechanism that might enable scientists to multiply adult stem cells quickly and efficiently.

"These findings provide us with a new way of looking at adult stem cells and for possibly exploiting their therapeutic potential," says Jaenisch, who also is a professor of biology at MIT.

This research focuses on a gene called Oct4, a molecule that is known to be active in the early embryonic stage of an organism. Oct4's primary function is to keep an embryo in an immature state. It acts as a gatekeeper, preventing the cells in the embryo from differentiating into tissue-specific cells. While Oct4 is operating, all the cells in the embryo remain identical, but when Oct4 shuts off, the cells begin growing into, say, heart or liver tissue.

Konrad Hochedlinger, a post-doctoral researcher in Jaenisch's lab, was experimenting with the Oct4 gene, curious to see what happens in laboratory mice when the gene is reactivated in adult tissue where it has long been dormant. Hochedlinger found that when he switched the gene on, the mice immediately formed tumors in the gut and in the skin where the gene was active. When he switched the gene off, the tumors subsided, demonstrating that the process is reversible.

Discovering that simply flipping a single gene on and off has such an immediate effect on a tumor was unexpected, even though Oct4 is known to be active in certain forms of testicul
'"/>

Source:Whitehead Institute for Biomedical Research


Page: 1 2

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. Researchers reveal the infectious impact of salmon farms on wild salmon
5. Researchers identify target for cancer drugs
6. Researchers discover molecule that causes secondary stroke
7. Researchers find missing genes of ancient organism
8. Researchers trace evolution to relatively simple genetic changes
9. Researchers add new tool to tumor-treatment arsenal
10. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
11. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
Post Your Comments:
(Date:7/25/2014)... SYRACUSE, N.Y., July 25, 2014 In the first broad-scale ... Forest Service scientists and collaborators calculated that trees are ... preventing 670,000 incidences of acute respiratory symptoms. , While ... improvement of less than 1 percent, the impacts of ... effects of the reduced air pollution at nearly $7 ...
(Date:7/25/2014)... autism and disrupted brain development is an essential ... is largely unknown. However, thanks to funding from ... Washington University (GW) researcher Anthony-Samuel LaMantia, Ph.D. may ... answers to these key questions in the field ... pharmacology and physiology at the GW School of ...
(Date:7/25/2014)... Diabetes increasingly consume the healthcare community and ... , To address the worldwide crisis ... middle-income countries, global leaders in diabetes, epidemiology ... diabetes prevention and development of diverse intervention ... , This book on "Global Health ...
Breaking Biology News(10 mins):First national study finds trees saving lives, reducing respiratory problems 2GW researcher receives grant to answer the how and why of autism during development 2What constitutes an effective response to the global 'diabesity' tsunami? 2
... new technique for turning embryonic stem cells into insulin-producing ... in the quest to find new treatments for diabetes. ... at the University of Sheffield, were able to genetically ... important protein known as a transcription factor. Stem ...
... camps atop glaciers in some of the most remote regions ... Branch at NASA,s Goddard Space Flight Center in Greenbelt, Md., ... Striking images taken by NASA satellites offer further visual evidence ... at the ends of the Earth. On Thursday, April ...
... Davis shows how our very short-term "working memory," which allows ... retains a limited number of high-resolution images for a few ... Humans rarely move their eyes smoothly. As our eyes flit ... to cut down visual "noise," said Steven J. Luck, professor ...
Cached Biology News:Stem cell breakthrough offers diabetes hope 2NASA expert to address Earth's vanishing polar ice, April 10, at UD 2Working memory has limited 'slots' 2
(Date:7/26/2014)... Albany, NY (PRWEB) July 26, 2014 ... 2020 provides key market data on the Canada ... in millions of US dollars, volume (in units) ... segments - High-End Endoscopy Visualization Systems, Mid-Range Endoscopy ... Browse Full Report at http://www.marketresearchreports.biz/analysis/213254 . , ...
(Date:7/25/2014)... , July 25, 2014 Amgen (NASDAQ: ... today declared a $0.61 per share dividend for the ... on Sept. 5, 2014, to all stockholders of record ... 2014.  About Amgen Amgen is committed ... from serious illnesses by discovering, developing, manufacturing and delivering ...
(Date:7/25/2014)... researchers from the University of Leicester has furthered ... the potential to create new materials using nanosized ... published in the prestigious academic journal Physical ... to examine in rich detail the structure and ... an acetylene molecule and a single helium atom. ...
(Date:7/25/2014)... New York (PRWEB) July 25, 2014 ... Market Research, "Biological Drugs Market - Global Industry Analysis, ... the global biological drugs market is estimated at USD ... at a CAGR of 10.1% from 2014 to 2020, ... in 2020. , The biological drugs market is witnessing ...
Breaking Biology Technology:Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 2Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 3Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 4Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 5Amgen Announces 2014 Third Quarter Dividend 2Amgen Announces 2014 Third Quarter Dividend 3Breakthrough laser experiment reveals liquid-like motion of atoms in an ultra-cold cluster 2Breakthrough laser experiment reveals liquid-like motion of atoms in an ultra-cold cluster 3Biological Drugs Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 2Biological Drugs Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 3
... and BERLIN , May 31, 2010 ... Assessment in patients with IRon deficiency,and Chronic Heart Failure) ... can improve renal function in,chronic heart failure patients. Ferinject(R) ... deficiency and iron deficiency anaemia. These,results were now presented ...
... In a development that could lead to novel carbon ... the Technion-Israel Institute of Technology today unveiled a new ... carbon called graphene. The research is available online ... stacked together, graphene sheets make graphite, which has been ...
... ... effort to provide a detailed “road map” defining all aspects of the future 110-acre ... development of programs, site planning, and real estate development planning, as well as maintenance ... ...
Cached Biology Technology:FAIR-HF Subanalysis Shows That Ferinject(R) Improves Kidney Function in Iron-Deficient Patients With Chronic Heart Failure 2FAIR-HF Subanalysis Shows That Ferinject(R) Improves Kidney Function in Iron-Deficient Patients With Chronic Heart Failure 3FAIR-HF Subanalysis Shows That Ferinject(R) Improves Kidney Function in Iron-Deficient Patients With Chronic Heart Failure 4FAIR-HF Subanalysis Shows That Ferinject(R) Improves Kidney Function in Iron-Deficient Patients With Chronic Heart Failure 5FAIR-HF Subanalysis Shows That Ferinject(R) Improves Kidney Function in Iron-Deficient Patients With Chronic Heart Failure 6Liquid method: pure graphene production 2Flad Architects Awarded Livermore Valley Open Campus Master Plan 2
Normal donkey serum collected from healthy normal donkeys....
Whole blood is collected from canines (any breed, either sex), refrigerated within 6 hours, processed within 24 hours and frozen at -20C....
... BAC (100+kb), fosmid (40kb), and large plasmid ... any othe BAC vector. On command 20-50 ... easy recombinant DNA purification. Available with blue-white ... vectors for the highest insert stability. Kits ...
Because it is manufactured at our ISO 9001–certified facilities in Eugene, Oregon, we can guarantee that FluoroPure grade propidium iodide is greater than or equal to 98% pure by HPLC....
Biology Products: