Navigation Links
Researchers discover mechanism for multiplying adult stem cells

While the field of human embryonic stem cell research receives a tremendous amount of public attention, many scientists are also exploring the potential of adult stem cells for possible therapies. But this field raises other difficulties. Although adult stem cell research isn't fraught with the controversies that surround embryonic stem cells, adult stem cells are extremely difficult to isolate and then to multiply in a lab dish. Now, as reported in the May 6 issue of the journal Cell, researchers in the lab of Whitehead Institute Member Rudolf Jaenisch have discovered a mechanism that might enable scientists to multiply adult stem cells quickly and efficiently.

"These findings provide us with a new way of looking at adult stem cells and for possibly exploiting their therapeutic potential," says Jaenisch, who also is a professor of biology at MIT.

This research focuses on a gene called Oct4, a molecule that is known to be active in the early embryonic stage of an organism. Oct4's primary function is to keep an embryo in an immature state. It acts as a gatekeeper, preventing the cells in the embryo from differentiating into tissue-specific cells. While Oct4 is operating, all the cells in the embryo remain identical, but when Oct4 shuts off, the cells begin growing into, say, heart or liver tissue.

Konrad Hochedlinger, a post-doctoral researcher in Jaenisch's lab, was experimenting with the Oct4 gene, curious to see what happens in laboratory mice when the gene is reactivated in adult tissue where it has long been dormant. Hochedlinger found that when he switched the gene on, the mice immediately formed tumors in the gut and in the skin where the gene was active. When he switched the gene off, the tumors subsided, demonstrating that the process is reversible.

Discovering that simply flipping a single gene on and off has such an immediate effect on a tumor was unexpected, even though Oct4 is known to be active in certain forms of testicul
'"/>

Source:Whitehead Institute for Biomedical Research


Page: 1 2

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. Researchers reveal the infectious impact of salmon farms on wild salmon
5. Researchers identify target for cancer drugs
6. Researchers discover molecule that causes secondary stroke
7. Researchers find missing genes of ancient organism
8. Researchers trace evolution to relatively simple genetic changes
9. Researchers add new tool to tumor-treatment arsenal
10. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
11. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
Post Your Comments:
(Date:4/17/2015)... 2015 Increasing adoption ... advancement to drive biometric systems market in ... According to a recently released TechSci ... ", biometric systems market in Saudi ... at CAGR of over 22% through 2020. The ...
(Date:4/13/2015)... 13, 2015 According to ... Biometrics Market Forecast & Opportunities, 2020", the global biometrics ... around 14% till 2020. The biometrics market is ... implementation and review of biometric management systems. The ... products with greater efficiency, are resulting in increasing ...
(Date:4/9/2015)... , April 9, 2015 Synaptics Inc. (NASDAQ: ... solutions, announced today that it will report financial results ... April 23, 2015, after the close of market. The ... and investors at 2:00 p.m. PT (5:00 p.m. ET), ... To participate on the live call, analysts and ...
Breaking Biology News(10 mins):Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2Synaptics to Report Third Quarter Results on April 23 2
... to two-thirds of Earth,s permafrost likely will disappear by ... quantities of carbon into the atmosphere, says a new ... for Research in Environmental Sciences. The ... to thaw in high latitudes from warming temperatures, which ...
... CHAMPAIGN, lll. University of Illinois animal sciences professor ... Prize in Agriculture. He shares the prize with James ... Wolf Prizes are awarded each year, with recipients in ... prize committee selected Lewin for his "highly significant discoveries" ...
... proteins in the blood of pregnant women that could be ... in discovery of biomarkers that seem to be specific enough ... a new study in ACS,s Journal of Proteome Research ... happens when an embryo does not attach normally inside the ...
Cached Biology News:Thawing permafrost likely will accelerate global warming 2Thawing permafrost likely will accelerate global warming 3Illinois professor awarded 2011 Wolf Prize in Agriculture 2
(Date:5/4/2015)... , May 4, 2015 /PRNewswire/ - The ... partners are pleased to announce the formation of ... on developing treatments for cancer that harness the ... represents a unique collaboration between the Children,s Hospital ... Research Institute, McMaster University, the Ontario Institute for ...
(Date:5/4/2015)... (PRWEB) May 04, 2015 Achieved primarily ... produces slides that boast 10 to 100x better detail ... the capabilities of all existing light microscopy methods, it ... micrographs were chosen as the frame of reference because ... , The goal from the earliest discovery days ...
(Date:5/4/2015)... 4, 2015 - New Massive ... students prepare for the United States Medical Licensing Examination ... scientific, technical and medical information products and services, announced ... Open Online Course) designed to help medical students prepare ... 1, the first and most daunting of the three ...
(Date:5/4/2015)... ALISO VIEJO, Calif. , May 4, 2015 /PRNewswire/ ... to eliminate preventable hospitalizations, has teamed with the ... effect of Sentrian technology on 1,000 patients with chronic ... nearly 13 million Americans and is the nation,s third ... plan members of CareMore Health System , a ...
Breaking Biology Technology:Turnstone Biologics Inc. to accelerate clinical and commercial translation of cancer immunotherapies 2Turnstone Biologics Inc. to accelerate clinical and commercial translation of cancer immunotherapies 3Elsevier's Free MOOC Prepares Med Students for Licensing Exam 2Elsevier's Free MOOC Prepares Med Students for Licensing Exam 3CareMore, Scripps Translational Science Institute, and Sentrian Launch Landmark Study of Remote Patient Monitoring for COPD Population 2CareMore, Scripps Translational Science Institute, and Sentrian Launch Landmark Study of Remote Patient Monitoring for COPD Population 3CareMore, Scripps Translational Science Institute, and Sentrian Launch Landmark Study of Remote Patient Monitoring for COPD Population 4CareMore, Scripps Translational Science Institute, and Sentrian Launch Landmark Study of Remote Patient Monitoring for COPD Population 5
... a three-year Phase II small business innovation research ... Institute for Environmental Health Sciences. , ,The grant ... for the measurement of low-dose, cumulative exposure to ... sensitive, inexpensive, rugged and suitable for studies involving ...
... heavy damage from Hurricane Charley, which threatened Tampa, Fla., ... Carolina. Source: Beau McCune. MADISON Insurance companies ... to speed claims processing for disaster victims. These companies ... process their portion of the $7.4 billion in losses ...
... argue about improvement. Motherhood, apple pie, the Packers, Badgers and ... apt to cause a fight after a few beers. Everyone ... things worse the next time. Einstein's theory of human nature ... defined insanity as doing the same things over and over ...
Cached Biology Technology:Wisconsins insurance companies use advanced IT to speed relief 2Wisconsins insurance companies use advanced IT to speed relief 3The Real World 2The Real World 3
... synthetic peptide whose sequence corresponds to residues 1-18 from rat rab ... terminus): M(1) - A - S - A - S - ... - R - D - A - A - D - ... neutralization and control experiments with the polyclonal antibody that reacts with ...
... RNA sequences from high throughput synthesis are new ... LC Sciences. These products provide a large number ... sequences delivered in a microtube as a mixture ... verified RNA sequence. This is a custom product ...
... gold standard for automated bioresearch: Developed ... applications • Based on decades of ... accessories designed for bioresearch • Holographic ... Versatility, reliability and ease-of-use • Pulsed ...
... Acuity is the complete enterprise microarray informatics platform ... analysis. Buy Acuity once and use it forever ... Tools for Quality Acuity has all the ... from your data, from quality control statistics and ...
Biology Products: