Navigation Links
Researchers discover how malaria parasite disperses from red blood cells

ned the blood cells green, the other stained the parasites red.

In the first stage of the merozoites' release, which the researchers dubbed the "irregular schizont" stage, the red blood cell resembles a lop-sided fried egg, with the parasites visible as a sphere near the center of the cell. (A diagram of the entire sequence appears at http://www.nichd.nih.gov/new/releases/malaria_graphic.cfm.) The cell's lop-sided appearance probably results from destruction of the cytoskeleton, the molecular scaffolding that helps the cell to maintain its rounded shape.

In the next stage, called the "flower" stage, the red blood cell assumes a roughly spherical shape, covered with rounded structures that resemble the petals of a flower. Shortly thereafter, the blood cell's membrane appears to break apart. At roughly the same time, cellular compartments, called vacuoles, which encase the newly formed merozoites, also break apart. The entire process has an explosive appearance, dispersing the merozoites some distance from the cell.

During the release, Dr. Zimmerberg explained, the cell membrane appears to collapse inward upon itself and fragment into pieces.

One previous theory held that the red blood cells and the merozoite-containing vacuoles inside them swelled and then burst like a balloon containing too much air.

"The swelling was an artifact of too much light from the microscope," Dr. Zimmerberg said. "The cell membrane was light sensitive. When we turned the light down, we didn't see the swelling." Rather, he said, upon release of the merozoites, the cell membrane appeared to contract in upon itself.

Another theory held that the merozoite-containing vacuoles would fuse with the cell membrane, and then release their contents.

"But we didn't see any fusion," Dr. Zimmerberg said.

The third theory held that the cell membrane ruptured, ex
'"/>

Source:NIH/National Institute of Child Health and Human Development


Page: 1 2 3

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. Researchers reveal the infectious impact of salmon farms on wild salmon
5. Researchers identify target for cancer drugs
6. Researchers discover molecule that causes secondary stroke
7. Researchers find missing genes of ancient organism
8. Researchers trace evolution to relatively simple genetic changes
9. Researchers add new tool to tumor-treatment arsenal
10. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
11. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
Post Your Comments:
(Date:11/7/2014)... led by Dr. Debra Auguste, associate professor, biomedical ... The City College of New York, have identified ... for one of the most aggressive forms of ... have a high mortality rate owing to aggressive ... therapeutic options. However, Professor Auguste,s team, discovered the ...
(Date:11/6/2014)... for a predator. Except when that predator runs so fast ... to its size, is the fastest creature on Earth. Some ... second (at about five miles per hour). The fastest human ... gold from the tiger beetle, a person would have to ... has a problem. At peak speeds, everything becomes a blur. ...
(Date:11/4/2014)... LAKE CITY, Nov. 5, 2014 – University of Utah ... enzymes to help jet fuel produce electricity without needing ... be used to power portable electronics, off-grid power and ... online today in the American Chemical Society journal ... electricity through a chemical reaction between a fuel and ...
Breaking Biology News(10 mins):The tiger beetle: Too fast to see 2Jet-fueled electricity at room temperature 2
... nature or nurture determines an ant,s status in the ... Nature (that is, the ant,s genetic makeup) and nurture ... determining the fate of the Florida harvester ant, Pogonomyrmex ... the southeastern United States. The research team included ...
... in three U.S. public schools are in the "air ... University of Cincinnati (UC). UC researchers have ... schools are within 400 meters, or a quarter mile, ... and traffic routes. Research has shown that ...
... found in biology. Now, chemists have succeeded in making ... surface, much like miniature bedsprings in a frame. This ... can help researchers develop molecular electronics or solar cells, ... Physical chemists at the Department of Energy,s Pacific Northwest ...
Cached Biology News:Genes and nutrition influence caste in unusual species of harvester ant 2Genes and nutrition influence caste in unusual species of harvester ant 3Many US public schools in 'air pollution danger zone' 2Many US public schools in 'air pollution danger zone' 3Chemists make beds with soft landings 2Chemists make beds with soft landings 3
(Date:11/24/2014)... 2014 Continental Clinical Solutions, LLC ... clinical trials at its mid-Atlantic late-phase research facility, ... created with the idea of closing patient disparities ... in medical advances," said Continental's CEO, Saleh ... the immortal cell line of Henrietta Lacks, dubious ...
(Date:11/24/2014)... Senior Vice President, General Manager for Clinical ... acumen Elsevier , a world-leading provider ... congratulates Diane Bartoli , Senior Vice President and ... Solutions, for being recognized in the 13 th ... Profiles in Diversity Journal ® . ...
(Date:11/22/2014)... 2014 Prominent academics, leaders of ... on December 3rd at Genetic Rx, a networking ... will take place at the Joseph B. Martin ... discuss the present and future of genetic medicines—including ... gene editing—as well as the treatment of patients ...
(Date:11/22/2014)... November 22, 2014 The “Chiral ... Preparative), by Material (Metal, Glass, Plastic), by Application ... SFC] - Forecast to 2018” analyses and studies ... in North America, Europe, Asia, and Rest of ... and 15 figures spread through 135 pages and ...
Breaking Biology Technology:At Continental Clinical Solutions, CEO Saleh Stevens Focuses on Diversity in Clinical Trial Recruitment at Maryland Site 2At Continental Clinical Solutions, CEO Saleh Stevens Focuses on Diversity in Clinical Trial Recruitment at Maryland Site 3Elsevier Clinical Solutions' Diane Bartoli Featured In Profiles in Diversity Journal's 13th Annual Women Worth Watching Issue 2Elsevier Clinical Solutions' Diane Bartoli Featured In Profiles in Diversity Journal's 13th Annual Women Worth Watching Issue 3Pioneering Academics and Key Industry Leaders to Discuss Rare Diseases and the Emergence of New Genetic Medicines at Genetic Rx on December 3rd 2Chiral Chromatography Columns Market worth $87.8 Million by 2018 - New Research Report by MarketsandMarkets 2Chiral Chromatography Columns Market worth $87.8 Million by 2018 - New Research Report by MarketsandMarkets 3Chiral Chromatography Columns Market worth $87.8 Million by 2018 - New Research Report by MarketsandMarkets 4Chiral Chromatography Columns Market worth $87.8 Million by 2018 - New Research Report by MarketsandMarkets 5
... which examines the science and applications of invisibility, Martin McCall ... type of invisibility cloak that does not just hide objects ... an example, McCall and Kinsler explain how a thief could, ... a safe, without even the CCTV surveillance cameras being aware. ...
... Corporation (Nasdaq: DNDN ) today announced ... use of PROVENGE® (sipuleucel-T), the first autologous cellular ... symptomatic metastatic castrate resistant (hormone refractory) prostate cancer ... Food and Drug Administration (FDA) approved the Los ...
... Calif., June 30, 2011 OXIS International, Inc. (OTC Bulletin ... that it has named David Saloff to its Board of ... independent Directors. "We are very pleased to have ... OXIS International Board of Directors," said Anthony J. Cataldo, Chairman ...
Cached Biology Technology:Why 'event cloaks' could be the key to the ultimate bank heist 2Dendreon Announces Increased Capacity and Significant Reimbursement Decisions Supporting Broad Availability of PROVENGE 2Dendreon Announces Increased Capacity and Significant Reimbursement Decisions Supporting Broad Availability of PROVENGE 3Dendreon Announces Increased Capacity and Significant Reimbursement Decisions Supporting Broad Availability of PROVENGE 4OXIS International Names Healthcare Industry Entrepreneur David Saloff to Board of Directors 2OXIS International Names Healthcare Industry Entrepreneur David Saloff to Board of Directors 3
PMM2 Immunogen: PMM2 (NP_000294, 47 a.a. ~ 112 a.a) partial recombinant protein with GST tag. Storage: -20 C, Avoid Freeze/Thaw Cycles *Available for distribution in the US only...
Anti-MMP-14, catalytic domain, clone LEM-2/15.8 Immunogen: Synthetic peptide: amino acid sequence 218-233 within the catalytic domain Available Date: 38579...
KRIT1 Immunogen: KRIT1 (NP_004903, 637 a.a. ~ 737 a.a) partial recombinant protein with GST tag. Storage: -20 C, Avoid Freeze/Thaw Cycles *Available for distribution in the US only...
Evolutionarily conserved signaling intermediate in Toll pathway...
Biology Products: