Navigation Links
Researchers discover genetic cause for word-finding disease

Northwestern University researchers have discovered a genetic cause of a mysterious neurological disease in which people have trouble recalling and using words. The illness, Primary Progressive Aphasia, differs from Alzheimer's Disease in which a person's memory becomes impaired. In PPA, a little known form of dementia, people lose the ability to express themselves and understand speech.

"This discovery, for the first time, provides a molecular approach to understanding the causes and eventually the treatment for this disease, " said Marsel Mesulam, M.D., lead author of the study and the Ruth and Evelyn Dunbar Professor of Neurology and Psychiatry at The Feinberg School of Medicine at Northwestern University. Mesulam was the first scientist to identify the word-finding disease in 1982. He estimated it affects tens of thousands of people, though no exact statistics are available. People can begin to show symptoms of PPA as early as in their 40's and 50's.

Scientists discovered the gene mutation, called a progranulin gene mutation, in two unrelated families in which nearly all the siblings suffered from PPA. In the first family, three out of four siblings had the disease; in the second family, two out of three had it. These particular mutations were not observed in the healthy siblings or in more than 200 control samples.

The study was published in January Archives of Neurology and is discussed in an editorial in the journal.

"We're dealing with one of the most puzzling phenomenons in neurology," said Mesulam, director of Northwestern's Cognitive Neurology and Alzheimer's Disease Center. "Here is a disease that specifically attacks the language part of the brain on the left side. What makes it so specific? How does the disease target the language areas?"

"This finding will help us explore not just what causes the disease but the uniquely identifying features of human language. That's a pretty big question," added Mes
'"/>

Source:Northwestern University


Page: 1 2

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. Researchers reveal the infectious impact of salmon farms on wild salmon
5. Researchers identify target for cancer drugs
6. Researchers discover molecule that causes secondary stroke
7. Researchers find missing genes of ancient organism
8. Researchers trace evolution to relatively simple genetic changes
9. Researchers add new tool to tumor-treatment arsenal
10. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
11. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Researchers discover genetic cause for word finding disease

(Date:7/28/2014)... Food and Drug Administration (FDA) for other purposes can ... human cells, including those that cause Legionnaires, disease, brucellosis, ... mBio , the online open-access journal of the American ... non-antibiotic drugs that could one day help curb bacterial ... list inhibit the growth of at least three of ...
(Date:7/28/2014)... United States have a circulatory problem of the legs ... may even require surgery in serious cases. This disease ... turn, limb amputation. , At The University of Texas ... tested a non-surgical preventative treatment in a mouse model ... blood circulation. Their proof-of-concept study appears in the ...
(Date:7/28/2014)... that the effects of a commonly used anesthetic drug ... The study, published in this week,s issue of the ... at the University of California, San Diego and Weill ... concerns, arising from multiple studies on humans over the ... increase their susceptibility to long-term cognitive and behavioral deficits, ...
Breaking Biology News(10 mins):New route to identify drugs that can fight bacterial infections 2Scientists discover genetic switch that can prevent peripheral vascular disease in mice 2Study suggests disruptive effects of anesthesia on brain cell connections are temporary 2Study suggests disruptive effects of anesthesia on brain cell connections are temporary 3
... the lineage of primates, according to scientific gospel, social ... as food, territory and reproduction. , That may well ... groundbreaking study researchers from the University of Wisconsin-Madison have ... from basic motivations to be with one another. What's ...
... damaged by ultraviolet (UV) light. , Ohio State University ... to watch strands of DNA in the laboratory sustain damage ... common chemical reaction among a family of reactions on the ... this key reaction happens with astounding speed -- in less ...
... are creating a technology that will allow doctors and ... humans and animals and watch their bones move in ... , This high-resolution, high-speed imaging system will contribute ... injuries and help scientists understand the evolution of complex ...
Cached Biology News:In young mice, gregariousness seems to reside in the genes 2In young mice, gregariousness seems to reside in the genes 3Scientists see DNA get 'sunburned' for the first time 2Scientists see DNA get 'sunburned' for the first time 3Bones in motion: Brown scientists to create new 3-D X-ray system 2Bones in motion: Brown scientists to create new 3-D X-ray system 3
(Date:7/30/2014)... July 30, 2014 Adding to their ... weighing boat special – Buy 2 of any ... promotion will benefit lab technicians looking for durable and ... are ideal for multiple applications including weighing liquids, solid, ... of choices including diamond-shaped, hexagonal, square, aluminum weighing, and ...
(Date:7/30/2014)... (PRWEB) July 30, 2014 LayerBio, Inc., ... completion of its first round of seed financing from ... enable preliminary efforts to develop a novel sustained-release product ... of our investors and their commitment to this important ... LayerBio. "Ophthalmology is one of many areas in which ...
(Date:7/29/2014)... (PRWEB) July 30, 2014 “PharmaSphere: ... Equity and Venture Capital Funding” report provides in-depth ... the private equity and venture capital segments of ... are expected to have significant impact on the ... and globally. Furthermore, the report identifies regions of ...
(Date:7/29/2014)... 2014 The advanced optical methods and ... are driving a revolution in the neurosciences were the ... published by SPIE, the international society for optics ... the launch of the BRAIN Initiative in the United ... out a vision for and provide examples of the ...
Breaking Biology Technology:Weighing Boat Promotion Now Available at Pipette.com, Major Pipette Distributor 2Strategic Trends of Biotech Investment Industry (Private Equity and Venture Capital Funding) in New Report Available at MarketOptimizer.org 2Strategic Trends of Biotech Investment Industry (Private Equity and Venture Capital Funding) in New Report Available at MarketOptimizer.org 3Strategic Trends of Biotech Investment Industry (Private Equity and Venture Capital Funding) in New Report Available at MarketOptimizer.org 4SPIE Launches 'Neurophotonics' Journal with Special Section on BRAIN Initiative 2SPIE Launches 'Neurophotonics' Journal with Special Section on BRAIN Initiative 3SPIE Launches 'Neurophotonics' Journal with Special Section on BRAIN Initiative 4
... Solution ... U.S. Critical Care Crisis, BALTIMORE, May 20, 2008 ICU ... at hospitals using,the eICU(R) care delivery model, according to results released ... Multimedia News Release, go to:, http://www.prnewswire.com/mnr/visicu/33159/ , Data from more ...
... AMES, Iowa, May 20 Advanced Analytical Technologies,Inc. ... newest instrument platform,the DNA PROfiler(TM) system, at BIO ... the time to identify infections which could help,clinicians ... Dr. Steven J Lasky, CEO of AATI, states, ...
... Turtle Island Soup has launched a,new ... ingredients shown to have,important health benefits, including ... The new Souper Food soups are powered ... http://www.ganedenlabs.com/ourScience.html ), a probiotic that has been,shown ...
Cached Biology Technology:Video: Data From 185,000 ICU Admissions Show Significant Reductions in Mortality: 2Video: Data From 185,000 ICU Admissions Show Significant Reductions in Mortality: 3Video: Data From 185,000 ICU Admissions Show Significant Reductions in Mortality: 4Advanced Analytical Unveils New Instrument for Rapid Microbial Identification at BIO 2008 2Turtle Island Soup Gets 'Souped Up' with New Probiotic, GandenBC30 2Turtle Island Soup Gets 'Souped Up' with New Probiotic, GandenBC30 3
Nuclear/Cytosol Fractionation Kit Research Focus: other Storage Temperature: 4C Shipping Temperature: 4C...
Peptide-affinity Purified Polyclonal Antibody to MTR...
Polyclonal Antibody to AGAP1 / Centaurin, gamma 2...
Polyclonal Antibody to PRG3...
Biology Products: