The researchers screened a library of 10,000 small molecules, the practice is known as chemical genomics, to identify those that could positively or negatively affect gravity's effect on plant growth, which is closely linked to the movement of proteins through plant cell membranes, a process known as endomembrane trafficking.
"Well-characterized bioactive chemicals and their targets identified in the model plant, Arabidopsis, can be used in non-model species to improve agronomic traits and increase crop value," said research team leader, Distinguished Professor of Plant Cell Biology Natasha Raikhel.
The team published its findings in this week's issue of the Proceedings of the National Academy of Sciences in a paper titled, The Power of Chemical Genomics to Study the Link between Endomembrane System Components and Gravitropic Response. Her team included equal contributions from UCR colleagues Marci Surpin, Marcela Pierce-Rojas, Clay Carter, Glenn R. Hicks. Co-author Jacob Vasquez originally came to the Raikhel lab from San Bernardino Valley College as a participant in the National Science Foundation's Research Experiences for Undergraduates (REU) program in 2003 and has remained to contribute to research efforts while studying at UCR.
The team's chemical genomics approach focuses on the use of small molecules to modify or disrupt the functions of specific genes or proteins. NASA supported the research.
"This contrasts with classical genetics, in which mutations disrupt gene function," Raikhel said. "The underlying concept is that the functions of most proteins can be altered by the binding of a chemical, which can be found by screening large libraries for compounds that specifically
Source:University of California - Riverside