Navigation Links
Researchers discover 'acquired' DNA key to certain bacterial infection

Researchers announced this week the discovery of a mechanism by which Mycobacterium avium – a bacterium which can result in serious lung infections and is prevalent in emphysema and AIDS patients among others – infects tissue cells or “macrophages” and thus compromises the body’s immunity.

Results of the study, led by researchers at Oregon State University, will be published online this week in the Proceedings of the National Academy of Sciences. Other co-authors were from the University of Nebraska.

The key to the bacterium’s ability to enter environmental amoebas – and ultimately humans – is an “island” of genetic material acquired through evolution from another bacterium, according to Luiz E. Bermudez, a professor of biomedical sciences in OSU’s College of Veterinary Medicine and an author of the study.

“Without these acquired genes, the bacterium is very inefficient in infecting environmental amoeba, which is the environmental host,” Bermudez said. “In fact, its efficiency is close to zero. But with this ‘island’ of acquired genetic material, the bacterium finds a way to get inside the cells and it takes control, not the phagocyte.”

Phagocytes are cells that engulf and digest pathogens and cellular debris, and in humans serve as the body’s initial immune response.

The researchers did not find a similar island of acquired genetic material in two similar bacteria, Mycobacterium tuberculosis and Mycobacterium paratuberculosis, which causes Johne’s disease.

M. avium exists in the environment and is thought to infect humans when the infected environmental hosts – amoebas – are inhaled or swallowed.

Incidence of M. avium as a cause of syndromes may be decreasing because of changes in treatment for HIV-infected patients, according to the Centers for Disease Control and Prevention, which estimates that 1 out of 100,000 persons may be affected. However, CDC also notes that the bacterium’s resistance
'"/>

Source:Oregon State University


Page: 1 2

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. Researchers reveal the infectious impact of salmon farms on wild salmon
5. Researchers identify target for cancer drugs
6. Researchers discover molecule that causes secondary stroke
7. Researchers find missing genes of ancient organism
8. Researchers trace evolution to relatively simple genetic changes
9. Researchers add new tool to tumor-treatment arsenal
10. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
11. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
Post Your Comments:
(Date:9/23/2014)... Antarctic fish that manufacture their own "antifreeze" proteins ... suffer an unfortunate side effect, researchers funded by ... ice crystals that accumulate inside their bodies resist ... discovered what appears to be an undesirable consequence ... notothenioid fish," said University of Oregon doctoral student ...
(Date:9/23/2014)... new tissues during the healing process, cells must ... years, scientists believed this communication happened primarily through ... and the University of Pittsburgh have found that ... if not more crucial. The findings, published in ... the National Academy of Sciences , could lead ...
(Date:9/23/2014)... CHAMPAIGN, Ill. Scientists have scoured cow rumens and ... plant cell walls for the production of next-generation biofuels, ... reside in the human lower intestine, researchers report. , ... of the National Academy of Sciences , is the ... that microbes in the human gut can digest fiber, ...
Breaking Biology News(10 mins):Antifreeze proteins in Antarctic fish prevent both freezing and melting 2Antifreeze proteins in Antarctic fish prevent both freezing and melting 3The mechanics of tissue growth 2Search for better biofuels microbes leads to the human gut 2Search for better biofuels microbes leads to the human gut 3
... URBANA The first sequencing of the Asiatic pear ... of seven worldwide universities and institutions including the University ... to work on the strategy for sequencing, analyzing the ... the manuscript," said U of I plant molecular geneticist ...
... 12 June, 2012 GE Healthcare, the healthcare business ... genomics organization, jointly announced today a pioneering multi-year research ... collaboration is to help advance the potential global utility ... and toxicity testing by exploring the underlying genetic variation ...
... algae, barnacles, mussels and other organisms is a major ... a joint project, researchers at the University of Gothenburg ... environmentally-friendly and effective bottom paints to prevent this. ... consumption and so increased air pollution. It can also ...
Cached Biology News:Asiatic pear genome sequenced 2BGI, GE Healthcare team up on pioneering stem cell science projects 2New paints prevent fouling of ships' hulls 2
(Date:9/23/2014)... Dallas, Texas (PRWEB) September 23, 2014 ... report on the Global and China Isopropanol (IPA) ... the industry, including definitions, applications and industry chain ... analysis are provided with a focus on history, ... A comparison between the international and Chinese situation ...
(Date:9/23/2014)...   GenoSpace , a precision medicine software company ... enable the broad use of genomic data in research ... awarded Phase I of a Fast Track Small Business ... Health (NIH) to enable enhanced data access and cohort ... During the past decade, the ...
(Date:9/23/2014)... Texas Fertility Center (TFC) announces the opening of ... Central Texas footprint that includes Round Rock, Central Austin, ... the region’s most established practice will provide full service ... Kyle and San Marcos communities. , “We want ... individuals and couples living in and around South Austin,” ...
(Date:9/23/2014)... Dr. Williams says, “Find The Black ... offers a three phase process that can lead to ... that would go far beyond anything previously imagined. First ... of healthcare.” , “Every effort to improve the quality ... discernable progress throughout that system because all of the ...
Breaking Biology Technology:(IPA) Isopropanol Industry International & China Development Trend Analysis Now Available at DeepResearchReports.com 2(IPA) Isopropanol Industry International & China Development Trend Analysis Now Available at DeepResearchReports.com 3GenoSpace Awarded Fast Track SBIR Grant to Enable Data Access and Cohort Construction for Biorepositories 2Opening Doors to a Family: Texas Fertility Center Announces Newest Fertility Clinic in South Austin 2Opening Doors to a Family: Texas Fertility Center Announces Newest Fertility Clinic in South Austin 3Dr. Ira Williams Offers the Healthcare Solution Necessary for Patient Safety Improvement 2
... , STOCKHOLM, ... European Investment Fund (EIF) has entered into a,co-investment agreement ... Karolinska Development and used to invest in the company,s,portfolio ... to invest 26.7 M Euros in the co-investment fund. ...
... Most people would like to be able to charge ... not too often. A recent discovery made by UC ... that could do just this. In recent ... Bandaru, a professor in the UCSD Department of Mechanical ...
... , BETHESDA, Md., Nov. 19 ... for diabetes therapy, and a provider of technical and regulatory ... today it closed the previously reported $6.3 million registered direct ... stock and warrants to purchase up to 1,104,348 additional shares ...
Cached Biology Technology:Karolinska Development and EIF Start Landmark Co-Investment Fund for Life Science Innovation 2Karolinska Development and EIF Start Landmark Co-Investment Fund for Life Science Innovation 3Nanotube defects equal better energy and storage systems 2Spherix Announces the Closing of $6.3 Million Registered Direct Offering 2Spherix Announces the Closing of $6.3 Million Registered Direct Offering 3
The Zymo-Spin PI Fast-Spin column features durable polypropylene construction and is the same column featured in the His-Spin Protein Miniprep. Capacity is 800 l....
... Sensitivity Freezing Point Osmometer for 10 ... volume applications, including pediatric, neonatal, geriatric, ... Automatic Calibration with 2 or ... printer, keypad and software for statistical ...
Several Pichia pastoris strains are available to allow you to optimize expression and recovery of your protein of interest. Table 1 provides information to help you choose the appropriate strain....
RayBio Human Atherosclerosis Antibody Array 1.1 (4) with Accessory, detects 40 inflammatory factors (for lysate) Class: Antibody Array Products Product Group: Antibody Array...
Biology Products: