Navigation Links
Researchers develop rapid diagnostic tool for pathogen identification

Researchers at Columbia University's Mailman School of Public Health and the Columbia Genome Center have designed and developed a sensitive new diagnostic technology platform, called “Mass Tag PCR,?that can simultaneously screen for multiple infectious agents. The new technology is addressed in a paper published in the February issue of the Centers for Disease Control and Prevention's (CDC) Emerging Infectious Diseases. This new platform is demonstrated in an assay that detects and discriminates 22 pathogens including viruses and bacteria that can present as clinically similar pulmonary disease.


This new technology platform addresses important challenges for infectious disease identification—sensitivity and breadth. Mass Tag PCR provides the ability to be precise in identification, as well as the ability to apply current diagnostics to more than one pathogen at a time, thereby reducing the time needed for differential diagnosis.

“We focused first on respiratory diseases because differential diagnosis is a common clinical problem with implications for outbreak control and individual case management,?stated W. Ian Lipkin, MD, Jerome L. and Dawn Greene Professor of Epidemiology and professor of Neurology and Pathology at Columbia University , and senior author of the paper. “However, we envision implementing this method for a wide variety of applications such as blood product surveillance, agriculture, forensic microbiology, and biodefense.?/p>

To address the need for highly sensitive diagnostics, researchers built on an established method known as polymerase chain reaction that allows amplification of genetic sequences and on a technology previously used for DNA sequencing and detection of genetic polymorphisms. Genetic probes for pathogens were coupled to markers known as mass codes. After amplification, incorporated mass codes were detected by mass spectroscopy allowing identification of the pathogen.

According to Thomas Briese, PhD
'"/>

Source:Columbia University's Mailman School of Public Health


Page: 1 2

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. Researchers reveal the infectious impact of salmon farms on wild salmon
5. Researchers identify target for cancer drugs
6. Researchers discover molecule that causes secondary stroke
7. Researchers find missing genes of ancient organism
8. Researchers trace evolution to relatively simple genetic changes
9. Researchers add new tool to tumor-treatment arsenal
10. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
11. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
Post Your Comments:
(Date:7/31/2015)... julio de 2015 BGI llevará a cabo la ... 22 al 25 de octubre de 2015, en ... celebra su décimo aniversario este año. Desde su inauguración ... las reuniones anuales más influyentes del mundo en los ... conferencias científicas más dinámicas, entusiastas y amenas. ...
(Date:7/31/2015)... Chine, 31 juillet 2015 La 10e ... ) sera organisée par le BGI du 22 ... en Chine. La conférence ... inauguration en 2006, l,ICG est devenue l,une des ... domaine des « omiques » et c,est aussi la plus ...
(Date:7/31/2015)... 31. Juli 2015 Die 10. internationale Konferenz zu ... veranstaltet und findet vom 22. bis 25. Oktober ... statt. Die Konferenz feiert in ... 2006 ist die ICG weltweit zu einem der ... ist eines der dynamischsten, enthusiastischsten und angenehmsten wissenschaftlichen ...
Breaking Biology News(10 mins):La 10ª Conferencia Internacional sobre Genómica (ICG-10) comienza en octubre 2La 10ª Conferencia Internacional sobre Genómica (ICG-10) comienza en octubre 3La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 2La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 3Die 10. internationale Konferenz zu Genomik (ICG-10) beginnt im Oktober 2Die 10. internationale Konferenz zu Genomik (ICG-10) beginnt im Oktober 3
... faced with everyday obstacles in their physical environments and ... with them. Navigating these obstacles can involve highly complex ... work, researchers have employed an ingenious obstacle-based system for ... in the fruit fly Drosophila. , The findings ...
... tailored therapiesContinuing its strong support for studies on ... Institutes of Health anticipates spending more than $150 ... Research Network (PGRN). The research of this nationwide ... drug prescriptions to people's unique genetic make-ups. ...
... have found a family of proteins that enhances the sensitivity ... growth and cancer. Their discovery could lead to a completely ... new drugs to stop uncontrolled growth in a wide variety ... Oxford, funded in part by the Biotechnology and Biological Sciences ...
Cached Biology News:Gap-climbing fruit flies reveal components of goal-driven behaviors 2NIH renews network focused on how genes influence drug responses 2NIH renews network focused on how genes influence drug responses 3NIH renews network focused on how genes influence drug responses 4Fruit fly studies open new window on cancer research 2
(Date:9/1/2015)... (PRWEB) , ... September 01, ... ... the launch of the new ImageXpress® Micro Confocal High-Content Imaging System. This ... emerging assays that use 3D cellular models such as spheroids, tissues, and ...
(Date:9/1/2015)... , ... September 01, 2015 , ... ... recombinant antibodies, announced today that the National Institutes of Health (NIH) has awarded ... will be administered by the NIH’s National Institute of Diabetes and Digestive and ...
(Date:9/1/2015)... 1, 2015 The Dohmen Company today ... Ph.D., MBA as Chief Science Officer (CSO) of ... created role, Dr. Floyd will lead Dohmen,s growing ... of pre-commercial and post approval outsourced services in ... communications.  Dr. Floyd brings decades of experience leading ...
(Date:9/1/2015)... ... ... Knowledgent , the data and analytics firm, today announced a new ... in the healthcare industry. , As the Internet of Things (IoT) continues to grab ... few years as more entities become technology enabled through Electronic Medical Records (EMRs). , ...
Breaking Biology Technology:ImageXpress Micro Confocal High-Content Imaging System Expands the Boundaries of Research 2ImageXpress Micro Confocal High-Content Imaging System Expands the Boundaries of Research 3AxioMx Announces Receipt of SBIR Grant for DNA-Protein Complex Antigen Development 2AxioMx Announces Receipt of SBIR Grant for DNA-Protein Complex Antigen Development 3Dohmen Life Science Services Appoints Eric Floyd, Ph.D. as Chief Science Officer 2Dohmen Life Science Services Appoints Eric Floyd, Ph.D. as Chief Science Officer 3New White Paper Explores Data Lake Opportunities in the Healthcare Industry 2
... ground-breaking treatment option for victims of whiplash associated disorders (WAD). ... Z Therapy is the first and only rehabilitation specialist in North ... neck pain. , ... Dallas, TX (PRWEB) April 21, ...
... NxStage Medical, Inc. (Nasdaq: NXTM ), a ... to release its financial results for the first quarter ... before the opening of the financial markets.NxStage will also ... on Friday, May 8, 2009 to discuss its first ...
... LLC announced today that it has issued an Executive ... 56-page report can be found at www.crystalra.com ... is a closely held pharmaceutical company focused exclusively on ... a technology spinout from Bayer HealthCare LLC, ACT Biotech ...
Cached Biology Technology:Z Therapy Is The First In North Texas To Offer Revolutionary Treatment Option For Neck Pain Sufferers 2NxStage to Report First Quarter 2009 Financial Results 2Crystal Research Associates, LLC Issues an Executive Informational Overview(R) (EIO(R)) on ACT Biotech, Inc. 2Crystal Research Associates, LLC Issues an Executive Informational Overview(R) (EIO(R)) on ACT Biotech, Inc. 3
... Peptide sequences: Two separate vials ... to the same sequence used as ... (Catalog No. 160890) ... Cayman's guanylate cyclase polyclonal antiserum (Catalog ...
... 3B8A10. Immunogen: Recombinant ... C-terminal region of human ... for the human ubiquilin ... (positive control: 293 cells). ...
... PinPoint™ Vector Sequencing Primer is designed for ... Vectors (Cat.# V2031, V2051, V2061). The primer ... at nucleotides 325343, approximately 4050 base pairs ... can be used to determine if an ...
... The versatile Zymo-Spin I-96 Plate can be ... manifolds for the large-scale (i.e., 96-well) purification ... polypropylene construction and unique silica-based matrix make ... g DNA or RNA in = 10 ...
Biology Products: