Navigation Links
Researchers develop rapid diagnostic tool for pathogen identification

Researchers at Columbia University's Mailman School of Public Health and the Columbia Genome Center have designed and developed a sensitive new diagnostic technology platform, called “Mass Tag PCR,?that can simultaneously screen for multiple infectious agents. The new technology is addressed in a paper published in the February issue of the Centers for Disease Control and Prevention's (CDC) Emerging Infectious Diseases. This new platform is demonstrated in an assay that detects and discriminates 22 pathogens including viruses and bacteria that can present as clinically similar pulmonary disease.


This new technology platform addresses important challenges for infectious disease identification—sensitivity and breadth. Mass Tag PCR provides the ability to be precise in identification, as well as the ability to apply current diagnostics to more than one pathogen at a time, thereby reducing the time needed for differential diagnosis.

“We focused first on respiratory diseases because differential diagnosis is a common clinical problem with implications for outbreak control and individual case management,?stated W. Ian Lipkin, MD, Jerome L. and Dawn Greene Professor of Epidemiology and professor of Neurology and Pathology at Columbia University , and senior author of the paper. “However, we envision implementing this method for a wide variety of applications such as blood product surveillance, agriculture, forensic microbiology, and biodefense.?/p>

To address the need for highly sensitive diagnostics, researchers built on an established method known as polymerase chain reaction that allows amplification of genetic sequences and on a technology previously used for DNA sequencing and detection of genetic polymorphisms. Genetic probes for pathogens were coupled to markers known as mass codes. After amplification, incorporated mass codes were detected by mass spectroscopy allowing identification of the pathogen.

According to Thomas Briese, PhD
'"/>

Source:Columbia University's Mailman School of Public Health


Page: 1 2

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. Researchers reveal the infectious impact of salmon farms on wild salmon
5. Researchers identify target for cancer drugs
6. Researchers discover molecule that causes secondary stroke
7. Researchers find missing genes of ancient organism
8. Researchers trace evolution to relatively simple genetic changes
9. Researchers add new tool to tumor-treatment arsenal
10. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
11. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
Post Your Comments:
(Date:5/22/2013)... Adventitious changes in cellular DNA can endanger the whole ... cancer. Researchers at Ludwig-Maximilians-Universitaet (LMU) in Munich now report ... the double helix. , The DNA in our cells ... in our bodies. The instructions for this are encoded ... in DNA, the bases adenine (A), cytosine (C), guanine ...
(Date:5/22/2013)... NEW YORK, May 22, 2013. Plastic additives known ... just about everywhere: They turn up in flooring, ... andaccording to the Centers for Disease Control and ... harmless, phthalates have come under increasing scrutiny. A ... phthalates (which can leech from packaging and mix ...
(Date:5/21/2013)... the body, stem cells in the blood often ... mature immune cells that can fight off illness. ... cell populations, potentially leading to the development of ... team of researchers led by biologists at the ... in mouse models, the molecule microRNA-146a (miR-146a) acts ...
Breaking Biology News(10 mins):DNA damage: The dark side of respiration 2Study links chemicals widely found in plastics and processed food to elevated blood pressure in children and teens 2Keeping stem cells strong 2
... Tufts University today announced the public launch of the ... The Institute is university-wide, global pharmaceutical ... portfolio of drug discovery and development partnerships. ... Tufts University School of Medicine and Tufts University,s Advancement ...
... FASEB MARC (Minority Access to Research Careers) Program ... American College of Sports Medicine (ACSM) Southeast Chapter Annual ... awards are meant to promote the entry of underrepresented ... the basic science community and to encourage the participation ...
... it,s messy, smelly and typically problematic. Live bait is inconvenient ... more permanent lures, you run the risk of losing an ... of brightly colored plastic familiar from your father,s tackle box, ... Professor John Caprio and Mystic Tackleworks have changed all that ...
Cached Biology News:Tufts announces public launch of the Tufts Institute for Biomedical Partnerships website/HUB 2Tufts announces public launch of the Tufts Institute for Biomedical Partnerships website/HUB 3LSU biologist, chemical engineer partner with industry to develop best soft lure available 2LSU biologist, chemical engineer partner with industry to develop best soft lure available 3LSU biologist, chemical engineer partner with industry to develop best soft lure available 4
(Date:5/23/2013)... -- Northwest Biotherapeutics (NASDAQ: NWBO ) (NW ... immune therapies for solid tumor cancers, announced today that ... Society Of Clinical Oncology (ASCO) meeting in ... immune therapy.  (Logo: http://photos.prnewswire.com/prnh/20110329/SF73084LOGO ) ... conference focused on clinical treatment of cancer, with attendance ...
(Date:5/23/2013)... May 23, 2013  Verenium Corporation (Nasdaq: ... the development and commercialization of high-performance enzymes, today announced ... Officer, will present at two upcoming conferences. ... present at the Second Annual Marcum LLP Microcap Conference ... Hotel in New York City.  The presentation is scheduled ...
(Date:5/23/2013)... May 23, 2013 SynCardia Systems, Inc. ... only FDA, Health Canada and CE (Europe) approved Total ... in Scotland, which boasts more than 380,000 visitors annually, ... powered by the Freedom® portable driver as part ... most advanced exhibitions of its kind. , “BodyWorks ...
(Date:5/23/2013)... Bed bugs compromised Penn State. ... confirmed it. Meanwhile, My Cleaning Products offered complimentary samples of ... the pests without using harmful chemical elements. , Based ... the affected building was actually a dormitory , My ... made on May 13 and bed bug presence was confirmed ...
Breaking Biology Technology:NW Bio Exhibit at the Upcoming ASCO Meeting to Highlight its Leadership Role in Immune Therapy for Cancer 2NW Bio Exhibit at the Upcoming ASCO Meeting to Highlight its Leadership Role in Immune Therapy for Cancer 3Verenium To Present At Two Upcoming Conferences 2Verenium To Present At Two Upcoming Conferences 3SynCardia Total Artificial Heart Featured in $3 Million Exhibition at Glasgow Science Centre 2SynCardia Total Artificial Heart Featured in $3 Million Exhibition at Glasgow Science Centre 3Penn State Dorm Infested with Bed Bugs, My Cleaning Products Offers Complimentary Sample of Bed Bug Spray to Help Bed Bug Victims 2
... America,Inc. (OTC Bulletin Board: CBAI), the umbilical cord ... focused on,bringing the life saving potential of stem ... revenues for 2007 totaled $5.8,million, up 74 percent ... of an adjustment in how we recognized yearly ...
... Institute of Standards and Technology (NIST) have combined ... single microchip, a cryogenic sensor and a microrefrigerator. ... and faster precision analysis of materials such as ... upcoming issue of Applied Physics Letters,* the NIST ...
... Mr. Glynn has over 34 years of,combined financial, ... the life sciences industry for his role in the ... Glynn,retired from Invitrogen Corporation (Nasdaq: IVGN ) in ... several operating roles including CFO,President and COO and CEO. ...
Cached Biology Technology:Cord Blood America Reports $5.8 Million In Revenues In 2007, Up 74 Percent 2NIST micro sensor and micro fridge make cool pair 2eBioscience Corporation Announced Today That James Glynn Has Been Appointed to Its Board of Directors, Effective April 15, 2008 2
Mouse monoclonal [B314.1 (MAC 387)] to Macrophage L1 protein Calprotectin (rating: ****) ( Abpromise for all tested applications)....
MOUSE ANTI HUMAN CYTOKERATIN 1-8...
Request Info...
... Ether 30% concentration in ... Surfactant. Clear Solution. Recommended ... 1 mL of 30% ... to 400 mL of ...
Biology Products: