Navigation Links
Researchers develop promising new gene network analysis method

Compared with a long-used linear model, a correlation-based statistical method is a more reliable way to map complex gene interactions and pinpoint genes that may be potential cancer treatment targets, according to new Brown University research.

The research is important because it describes a promising new tool for tracing human gene connections, a task critical for understanding and treating cancer and other diseases. Results appeared this week in the online edition of the Proceedings of the National Academy of Sciences.

"Genes influence one another in many intricate ways," said Leon Cooper, professor of physics and neuroscience and director of the Institute for Brain and Neural Systems at Brown. "What we need is a map, or network, of these links. What we've identified in this project is a more effective method for making this map."

The research team ?which included scientists from the fields of biology, physics, statistics and computer science at Brown, Università di Bologna in Italy and Tel Aviv University in Israel ?set out to answer a question. When a deadly "oncoprotein" is switched on, what chain reaction of gene activity does it set off?

The protein, c-Myc, causes cells to multiply. If the protein is produced unchecked, it can cause breast, colon and other types of cancer. C-Myc contributes to more than 70,000 deaths in the United States each year.

Once the c-Myc switch is thrown, thousands of other genes start pumping out proteins or switching on other genes, which activates still more genes. One way to study this web of connections would be to set off the chain reaction and study it over time. To make that happen, Brown researchers came up with a clever experiment.

John Sedivy, a long-time c-Myc researcher and the director of Brown's Center for Genomics and Proteomics, developed rat cells that lacked the c-Myc gene. These cells were further modified to make a form of the c-Myc protein, which could be switched
'"/>

Source:Brown University


Page: 1 2

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. Researchers reveal the infectious impact of salmon farms on wild salmon
5. Researchers identify target for cancer drugs
6. Researchers discover molecule that causes secondary stroke
7. Researchers find missing genes of ancient organism
8. Researchers trace evolution to relatively simple genetic changes
9. Researchers add new tool to tumor-treatment arsenal
10. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
11. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Researchers develop promising new gene network analysis method

(Date:12/10/2014)... You,ve been here before: you desperately need to ... password, site key or the answer to your secret question. ... Today, Hoyos Labs , a digital ... finally put an end to the frustration that comes with ... 1U leverages a user,s smartphone to acquire his or her ...
(Date:12/10/2014)... , Dec. 08, 2014 Research and ... the addition of the "Biometrics Market in ... http://photos.prnewswire.com/prnh/20130307/600769 ... projects such as rural banking and upgradation of ... trends witnessed in the market. Besides the aforementioned ...
(Date:12/4/2014)... Fla. , Dec. 3, 2014  Crossmatch™, ... today announced that its DigitalPersona ® Pro ... readers have been deployed throughout First Bank branch ... South Carolina and Virginia. First ... Southern Pines, North Carolina , ...
Breaking Biology News(10 mins):The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3Biometrics Market in Japan 2014-2018: Key Vendors are DDS, Fujitsu, Hitachi and NEC 2First Bank Partners with Crossmatch to Increase Log In Security 2First Bank Partners with Crossmatch to Increase Log In Security 3
... The mating habits of marine turtle may help to protect ... research led by the University of Exeter. Published today (25 ... Society B , the study shows how the mating patterns ... them deal with the fact that global warming is leading ...
... Reston VA More than 7,000 toxicologists from every corner ... Toxicology (SOT) 51st Annual Meeting and ToxExpo, which will highlight ... ,The five-day meeting will take place at the Moscone Convention ... is the study of the adverse effects of chemical, physical ...
... at The University of Nottingham has taken us a step ... different environmental conditions and fight off attack from parasites. ... National Academy of Sciences of the United States of ... root growth in the plant Arabidopsis thaliana , or ...
Cached Biology News:Turtles' mating habits protect against effects of climate change 2Toxicologists' annual meeting in San Francisco to showcase the latest scientific achievements 2Improving crops from the roots up 2
(Date:12/17/2014)... Xeno Diagnostics has again received an ... COLA inspection. Xeno has met all criteria for ... organization. Accreditation is earned only by laboratories that ... demonstrate continued accuracy in the performance of proficiency ... , While the Laboratory Excellence award ...
(Date:12/17/2014)... , Dec. 17, 2014 CASI Pharmaceuticals, ... dedicated to the acquisition, development and commercialization of innovative ... the global market with a primary commercial focus on ... has been granted a Type C meeting with the ... meeting will be held in February 2015.  During this ...
(Date:12/15/2014)... Organovo Holdings, Inc. (NYSE MKT: ONVO) ... breakthrough 3D bioprinting technology,  today celebrated continued positive ... exVive3D TM Human Liver Tissue.  The product, ... release on November 18, has been recognized as ... for innovation. Most recently, on December ...
(Date:12/13/2014)... Dec. 12, 2014 /CNW/ - MaRS and Virgin Unite Canada, ... they have joined forces to support Canadian entrepreneurs tackling social ... Group Founder was at the MaRS Centre to announce the ... impact venture fund. This fund has $1 million in seed ... Vancouver -based Mindset Social Innovation Foundation, founded by ...
Breaking Biology Technology:Xeno Diagnostics Receives 3rd Award for Laboratory Excellence 2CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 2CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 3CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 4CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 5Organovo Celebrates a Positive 2014 Reception of its exVive3DTM Human Liver Tissue Product 2Organovo Celebrates a Positive 2014 Reception of its exVive3DTM Human Liver Tissue Product 3MaRS and Virgin Unite partner to invest in business as a force for good 2MaRS and Virgin Unite partner to invest in business as a force for good 3
... Aug. 27 Poniard,Pharmaceuticals, Inc. (Nasdaq: PARD ... that Jerry McMahon, Ph.D., chairman and CEO,will present ... The Thomas Weisel Partners Healthcare Conference 2007 on ... the Four Seasons Hotel in Boston. BioCentury,s ...
... Pharmaceuticals Inc.,("Heritage") and Ipca Laboratories Ltd. ("Ipca") announced ... alliance for the development, supply and,marketing of generic ... the Agreement, Ipca shall develop and register selected,products ... and marketing,rights to such products. The parties shall ...
... Anadys Pharmaceuticals,Inc. (Nasdaq: ANDS ), a ... novel medicines for the treatment of,hepatitis C virus ... Ph.D. has been promoted to the position of ... Ph.D. who plans to pursue,other opportunities. Dr. Worland ...
Cached Biology Technology:Poniard Pharmaceuticals Announces Participation in Upcoming Conferences 2Heritage and Ipca Enter Into Strategic Alliance for Generic Pharmaceutical Products 2Anadys Pharmaceuticals Appoints Steve Worland, Ph.D. as President and Chief Executive Officer 2Anadys Pharmaceuticals Appoints Steve Worland, Ph.D. as President and Chief Executive Officer 3
FluoSpheres® biotin-labeled microspheres, 1.0 µm, yellow-green fluorescent (505/515) *1% solids*...
The epitope is specific for TASK and is not present in any other known proteins tested so far.,SPECIES REACTIVITIES: The epitope is also highly conserved between mouse and rat (17/18 residues iden...
Rat Antibody to Kinase Suppressor Of Ras Recognises the kinase suppressor of Ras (KSR). Immunogen: Recombinant human KSR protein Specificity: human kinase supressor of Ras...
Request Info...
Biology Products: