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Researchers develop marker that identifies energy-producing centers in nerve cells

brain to another. Mitochondria in the neurons function like cellular powerhouses to produce those impulses through a metabolic process that combines oxygen with food calories. It is these nerve signals that cause muscles to move and thoughts to be processed. Dr. Chandrasekaran says the fluorescent marker system may make it possible to explore how neuronal activity and the mitochondrial energy-producing system are coordinated and how the interrelationship works.

The researchers say the establishment of the fluorescent marker in mice could unravel the mysteries of some of the most debilitating neurodegenerative diseases. The study's senior author, Tibor Kristian, Ph.D., an assistant professor in the Department of Anesthesiology at the University of Maryland School of Medicine, says there are animal models for several of these diseases including Parkinson's, Alzheimer's, amyotrophic lateral sclerosis (also known as ALS) and Huntington's disease. "The mice we have developed with the fluorescent protein could be bred with mouse models of various neurological diseases, so we could apply the ability to see mitochondria in neurons to the research of those diseases," says Dr. Kristian.

This mouse model could also be used to study the role of neuronal mitochondria in stroke and traumatic brain injury, according to Dr. Kristian. He says his investigators are developing a similar marker for glial cells in the brain.
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Source:University of Maryland Medical Center


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