Navigation Links
Researchers develop gene therapy to reverse pulmonary arterial hypertension

A University of Alberta research team has discovered important new information they hope will lead to more effective treatments for pulmonary arterial hypertension (PAH)--a deadly form of high blood pressure in the pulmonary arteries caused by uncontrolled cell growth. Therapies are currently limited for a disease that can lead to heart failure and death within a few years.

The researchers have shown that Survivin, a protein almost exclusively expressed in cancer, is also heavily expressed in both human and animal lung arteries with PAH. Survivin is an inhibitor of apoptosis--or programmed cell death--which promotes cancer by suppressing the body's ability to limit excessive cell growth.

Armed with this new information and using animal models, the researchers developed a nebulized and inhaled gene therapy to deliver an inactive Survivin-mutant via a virus--known in science as a "dominant negative construct"--effectively inhibiting endogenous Survivin. The therapy reversed PAH in rats and improved their heart function and their survival, thus holding out some promising avenues of treatment for human PAH. The team members believe that as in cancer, Survivin drives excessive cell growth in the PAH lung blood vessels.

"The most intriguing aspect," explains principal researcher Evangelos Michelakis, "is we've shown for the first time that this cancer protein is also expressed within the blood vessels of the lung in patients suffering with PAH, but not in normal human blood vessels, making survivin a very attractive target for selective intervention.

"This makes the proliferation of lung blood vessels in this disease a 'form of cancer' or a form of neoplasia to be more precise, first proposed by Drs. Voelkel and Tuder from the University of Colorado. We've demonstrated for the first time that, like cancer, apoptosis is suppressed in the lung blood vessel wall in this disease."

"Our biggest challenge in treating PAH is the fact we don
'"/>

Source:University of Alberta


Page: 1 2 3

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. Researchers reveal the infectious impact of salmon farms on wild salmon
5. Researchers identify target for cancer drugs
6. Researchers discover molecule that causes secondary stroke
7. Researchers find missing genes of ancient organism
8. Researchers trace evolution to relatively simple genetic changes
9. Researchers add new tool to tumor-treatment arsenal
10. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
11. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
Post Your Comments:
(Date:7/23/2014)... experiments using tissue samples cultured from cystic fibrosis patients, ... UNC Marsico Lung Institute have shown that a new ... another CF drug. , The finding, published today in ... a mutant CFTR protein becomes unstable and loses its ... the two drugs. The research offers several insights into ...
(Date:7/23/2014)... grip is affecting more than the color of people,s lawns. ... heat-loving amoeba commonly found in warm freshwater bodies, such as ... warmer than usual this year. , A 9-year-old Kansas girl ... swimming in several area lakes. The amoeba enters the body ... brain. Nose plugs can lower the odds of this rare ...
(Date:7/23/2014)... The Worldwide Innovative Networking in personalized cancer medicine, (the ... Center at Thomas Jefferson University will be ... member of this prestigious group in the Tri-State Area. ... of innovative personalized medicine to the patient by forging ... , "Our participation in the WIN consortium means Jefferson ...
Breaking Biology News(10 mins):UNC researchers find unsuspected characteristics of new CF drugs, offering potential paths to more effective therapies 2UNC researchers find unsuspected characteristics of new CF drugs, offering potential paths to more effective therapies 3UNC researchers find unsuspected characteristics of new CF drugs, offering potential paths to more effective therapies 4Diseases of another kind 2New partnership brings more personalized cancer treatment to Philadelphia 2
... Department of Energy has granted approval for SLAC National ... the world,s first hard X-ray laserto begin planning a ... began operation in April 2009, generates ultra-fast, ultra-bright pulses ... insights into the atomic world. LCLS-II would give investigators ...
... materials inside upright pipes can purify dirty water from ... and flushing toilets, according to Penn State horticulturists. ... Robert D. Cameron, doctoral student in horticulture. "So it ... on how we can take wastewater and turn it ...
... of wheat bran, is important both from the technological ... developed in the HEALTHGRAIN project to partly and selectively ... soluble fibre ingredient based on wheat bran. The ... prevention of lifestyle diseases such as diabetes, obesity, cardiovascular ...
Cached Biology News:First X-ray laser's early success brings approval for next-phase facility 2Roots meshed in waste materials could clean dirty water 2
(Date:7/24/2014)... 2014 Draper University, a top ... to announce that for 6 weeks this summer, ... converge on the Draper University campus in the ... program focused on entrepreneurship, building real-world skills, and ... running its sixth cohort, continues to refresh its ...
(Date:7/23/2014)... , July 24, 2014 Lyfebulb, the ... Inc. (OTCQX and NASDAQ OMX First North Premier, ... "the Company"), announced a collaboration to increase awareness ... night at an event attended by more than ... Lyfebulb is a health and wellness company dedicated ...
(Date:7/23/2014)... the Vienna University of Technology and the Maria ... perfect semiconductor crystals into a silicon nanowire. With ... fast and multi-functional processing units can be accommodated ... research results will be published in the journal ... the cornerstone of future chip technology, but the ...
(Date:7/23/2014)... 23, 2014  Having the right people at the ... accelerating business growth and achieving clinical and operational goals. ... Leadership Summit, July 20-22, 2014, in San ... executives and healthcare experts discussing how partnerships have positively ... President & Chief Executive Officer of Cape Regional Medical ...
Breaking Biology Technology:Summer Entrepreneurship Program Kicked Off by Draper University in Silicon Valley 2Summer Entrepreneurship Program Kicked Off by Draper University in Silicon Valley 3Innovative Collaboration To Increase Awareness Of Bullous Pemphigoid, A Rare Autoimmune Disease Of The Skin 2Innovative Collaboration To Increase Awareness Of Bullous Pemphigoid, A Rare Autoimmune Disease Of The Skin 3Innovative Collaboration To Increase Awareness Of Bullous Pemphigoid, A Rare Autoimmune Disease Of The Skin 4Innovative Collaboration To Increase Awareness Of Bullous Pemphigoid, A Rare Autoimmune Disease Of The Skin 5A crystal wedding in the nanocosmos 2MSC and Cape Regional Medical Center Partner to Improve Cost, Quality and Outcomes 2
... For 65 years, Mission Pharmacal Company has remained ... to provide the highest quality healthcare medications and treatments ... to be uncertain, this Texas-based company remains steadfast in ... to search for more and better prescription and consumer ...
... Fuels, Inc., (Pink Sheets: HRID ) announced ... CEO and President.  Mr. Cadena was the founder and ... Solutions, and will be instrumental in implementing the Company,s ... Mr. Cadena has over 25 years of extensive ...
... Md., Dec. 6, 2011 GenVec, Inc. (Nasdaq: ... the second milestone in its collaboration with Novartis (NYSE: ... treatments for hearing loss and balance disorders. The milestone ... development activities. "Completing this milestone reflects ...
Cached Biology Technology:Celebrating 65 Years of Providing Superior Healthcare Products, Mission Pharmacal Continues to Thrive 2Celebrating 65 Years of Providing Superior Healthcare Products, Mission Pharmacal Continues to Thrive 3Celebrating 65 Years of Providing Superior Healthcare Products, Mission Pharmacal Continues to Thrive 4Celebrating 65 Years of Providing Superior Healthcare Products, Mission Pharmacal Continues to Thrive 5Celebrating 65 Years of Providing Superior Healthcare Products, Mission Pharmacal Continues to Thrive 6Hybrid Fuels, Inc. Appoints Industry Expert as New CEO 2GenVec Achieves Second Milestone in Collaboration 2GenVec Achieves Second Milestone in Collaboration 3
Polyclonal Antibody to Coronin / CORO1C This antibody was developed against synthetic peptides corresponding to amino acids 407-420 of human CORO1C....
Peptide-affinity Purified Polyclonal Antibody to Retinoic Acid-Induced 3 (RAI3/RAIG1)...
...
Co-precipitant is free of background polynucleotides,Dnases,Rnases, proteases. 20mg/ml...
Biology Products: