Navigation Links
Researchers design pulsed mircrojet system to deliver protein drugs without pain or bruising

A team of UCSB researchers, in collaboration with colleagues from UC Berkeley and StrataGent Life Sciences, of Los Gatos, California, has designed a novel pulsed microjet system engineered to deliver protein drugs into the skin without the pain or bruising that deeper penetration injection systems cause. The research was published online today in the Proceedings of the National Academy of Sciences.

The effort to create needle-free drug delivery systems is driven by a combination of factors, including needle phobia, pain and discomfort, infections, and accidental needle sticks to healthcare providers. Currently, about 12 billion needle injections are performed every year for the delivery of vaccines and protein therapeutics such as insulin, growth hormone and erythropoietin, a red blood cell booster. Needle-free delivery of vaccines has recently been identified as one of the significant emerging challenges in global health.

The researchers felt that the pain and bruising caused by previously-developed jet injectors was caused by the deep penetration of jets into the skin, creating negative reactions of nerves and capillaries. The pulsed mircrojets engineered by the researchers combine high velocity (more than 100 meters per second) with very small jet diameters (between 50 and 100 micrometers), delivering only 2 to 15 nanoliters of liquid drug at a time. The research showed that the pulsed microjet system could be used to effectively deliver drugs for local and systemic applications without using needles.

"The microjet system delivers precise doses into superficial skin layers, thereby mitigating pain," says Samir Mitragotri, a professor of chemical engineering at UCSB and a lead author of the paper. The system was designed as an alternative to the macro-scale systems that had been causing pain and bruising. "We realized that we had to find a way to stop the jets from going deep into the skin," says Mitragotri. "Speeding the delivery, combined with using extremely small jet diameters and less liquid per pulsation, was shown to be more effective."


'"/>

Source:University of California - Santa Barbara


Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. Researchers reveal the infectious impact of salmon farms on wild salmon
5. Researchers identify target for cancer drugs
6. Researchers discover molecule that causes secondary stroke
7. Researchers find missing genes of ancient organism
8. Researchers trace evolution to relatively simple genetic changes
9. Researchers add new tool to tumor-treatment arsenal
10. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
11. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/28/2017)... , March 28, 2017 The ... Hardware (Camera, Monitors, Servers, Storage Devices), Software (Video Analytics, ... Region - Global Forecast to 2022", published by MarketsandMarkets, ... 2016 and is projected to reach USD 75.64 Billion ... and 2022. The base year considered for the study ...
(Date:3/24/2017)... 24, 2017 The Controller General of Immigration from ... Abdulla Algeen have received the prestigious international IAIR Award for the ... Continue Reading ... ... Controller Abdulla Algeen (small picture on the right) have received the IAIR ...
(Date:3/23/2017)... The report "Gesture Recognition and Touchless Sensing Market by Technology (Touch-based ... to 2022", published by MarketsandMarkets, the market is expected to be worth USD ... 2022. Continue Reading ... ... ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... and LAGUNA HILLS, Calif. , Oct. ... Cancer Research, London (ICR) and University ... SKY92, SkylineDx,s prognostic tool to risk-stratify patients with multiple myeloma ... MUK nine . The University of Leeds ... partly funded by Myeloma UK, and ICR will perform the ...
(Date:10/10/2017)... ... 2017 , ... San Diego-based team building and cooking events company, Lajollacooks4u, has ... The bold new look is part of a transformation to increase awareness, appeal to ... period. , It will also expand its service offering from its signature gourmet cooking ...
(Date:10/10/2017)... 10, 2017 International research firm Parks Associates announced ... at the TMA 2017 Annual Meeting , October 11 in ... residential home security market and how smart safety and security products impact ... Parks Associates: Smart Home ... "The residential security market has ...
(Date:10/9/2017)... DIEGO , Oct. 9, 2017  BioTech ... biological mechanism by which its ProCell stem cell ... critical limb ischemia.  The Company, demonstrated that treatment ... amount of limbs saved as compared to standard ... the molecule HGF resulted in reduction of therapeutic ...
Breaking Biology Technology: