Navigation Links
Researchers create pigs that produce heart-healthy omega-3 fatty acids

mors. Overall, the database used in the study represents more than 32,000 distinct genotypes of different cells within the tumors.

Using computational techniques to analyze the data, the researchers calculated measures of diversity inside the tumors. Essentially, they counted cell varieties and measured the genetic difference, or divergence, between those varieties. "Simply put, we took ecology measures of species diversity and translated them into measures of cell diversity within tumors," Maley says. The found a striking correlation between increased diversity of tumor cells and progression to cancer. For every additional cell variety detected in a tumor, the patient was twice as likely to progress to cancer.

Maley suggests that genetically diverse tumors have a high probability of generating mutant cells that will flourish and spread, allowing the tumor to transform and grow. In the future, in addition to serving as a biomarker for cancer risk, he adds, measures of genetic diversity might help doctors assess the success of cancer prevention therapies.

In fact, he speculates, genetic diversity among tumor cells might help explain why therapy sometimes fails. If a tumor contains a diverse population of cells, some of those cells are more likely to resist treatment, Maley says. Adapting to and surviving chemotherapy, these resistant cells could breed, leading to a cancer relapse. He hopes to pursue this hypothesis in the future. "More immediately," he adds, "we intend to validate the new study with other cohorts and other types of tumors."


'"/>

Source:University of Pittsburgh Medical Center


Page: 1 2

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. Researchers reveal the infectious impact of salmon farms on wild salmon
5. Researchers identify target for cancer drugs
6. Researchers discover molecule that causes secondary stroke
7. Researchers find missing genes of ancient organism
8. Researchers trace evolution to relatively simple genetic changes
9. Researchers add new tool to tumor-treatment arsenal
10. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
11. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
Post Your Comments:
(Date:8/20/2014)... seawater signals a relaxing trip to the shore. But ... comes with an environmental hitch. When certain sunblock ingredients ... become toxic to some of the ocean,s tiniest inhabitants, ... animals. Their study appears in the ACS journal ... David Snchez-Quiles point out that other than staying indoors, ...
(Date:8/20/2014)... rugs and plastic bags could one day be made ... petroleum, scientists are now reporting. The novel process they ... deal with its agricultural and plastic waste problems, appear ... Athanassiou, Ilker S. Bayer and colleagues at the Italian ... constantly growing. In 2012, its production reached 288 million ...
(Date:8/20/2014)... a colony of honeybees grows to about 4,000 members, ... cycle: the building of a special type of comb ... of experts from the Department of Neurobiology and Behaviour ... starts the reproductive cycle of honeybee colonies. The results ... Science of Nature . , Reproduction isn,t always ...
Breaking Biology News(10 mins):Worker bees 'know' when to invest in their reproductive future 2
... fruits and vegetables in ozone-enriched environments reduces spoilage explains ... Conference in Harrogate. Dr Ian Singleton explains how ozone ... as it leaves no residue on foods. It ... can be lost due to microbial spoilage. Dr Singleton ...
... The benefits of blueberry consumption have been demonstrated ... benefits derived from their high polyphenol content. Blueberries ... on everything from aging to metabolic syndrome. Recently, ... Denton, TX, examined whether blueberries could play a ...
... 2010 For years, scientists have thought of DNA as ... RNA transcription. Now, research led by scientists from the Florida ... also act to fine-tune the activity of certain proteins known ... it possible to design therapies that could activate specific genes ...
Cached Biology News:Ozone reduces fungal spoilage of fruits and vegetables 2Blueberries may inhibit development of fat cells 2Scripps Research scientists uncover new DNA role in modifying gene function 2Scripps Research scientists uncover new DNA role in modifying gene function 3
(Date:8/19/2014)... , Aug. 19, 2014 Research and Markets ... Supplies - Global Strategic Business Report" report to their offering. ... and Tissue Culture Supplies in US$ Thousands by the following Product ... comprehensive analytics for the US, Canada , ... Asia-Pacific , and Latin America . Annual ...
(Date:8/19/2014)... August 19, 2014 XenoTech announces ... and cost-effective metabolite production from bioactive small molecules. ... platform, the technology enables convenient and timely assessment ... to XenoTech’s Vice President of Commercial Operations, Christian ... assessing clinical risk can be measured directly by ...
(Date:8/19/2014)... , Aug. 19, 2014 /PRNewswire/ - iCo Therapeutics Inc. ... today reported results of its Oral Amphotericin B ... reservoirs.  The study, conducted by ImmuneCarta®, the immune ... vitro effectiveness of Oral Amp B in ... in individuals despite intensive treatment with antiretroviral therapy. ...
(Date:8/18/2014)... FREDERICK, Md. , Aug. 18, 2014 ... the maker of advanced consumer medical devices ... Kotak was interviewed by CEOLIVE.TV as ... The entire interview is available at ... interview Dr. Kotak explains to investors the ...
Breaking Biology Technology:Global Cell and Tissue Culture Supplies - Strategic Business Report 2014 2Beyond Metabolite Identification, Testable Quantities Now Offered by XenoTech 2Beyond Metabolite Identification, Testable Quantities Now Offered by XenoTech 3iCo Therapeutics Announces Positive Oral Amphotericin B Study Results 2iCo Therapeutics Announces Positive Oral Amphotericin B Study Results 3BioElectronics EVP Dr. Deepak Kotak Interviewed on CEO Live 2BioElectronics EVP Dr. Deepak Kotak Interviewed on CEO Live 3
... in Wisconsin, educations effect on the state economy and ... were a few of the many topics covered yesterday ... , ,The panel first discussed the relation between the ... Wisconsin-Madison Chancellor John Wiley began by citing ...
... a lot of lively correspondence with Midwest technology job seekers, ... hanging onto their jobs by their fingernails. , ,They write ... their experiences with finding a job, getting promoted and managing ... write about really annoying things that their co-workers and supervisors ...
... child waits for Christmas. Today, PalmOne introduces the ... I buy?" conundrum. , ,I saw the new Treo six weeks ... (Yes, even I take a break from the schmoozing to sneak ... fell in love. This newest handheld communicator takes everything that ...
Cached Biology Technology:UW and business leaders outline need for educated workers 2UW and business leaders outline need for educated workers 3Midwest technology bosses should stop flaunting their wealth at work 2Midwest technology bosses should stop flaunting their wealth at work 3Midwest technology bosses should stop flaunting their wealth at work 4Christmas comes early with Treo 650 2Christmas comes early with Treo 650 3