Navigation Links
Researchers create infectious hepatitis C virus in a test tube

A team of researchers led by scientists at The Rockefeller University has produced for the first time an infectious form of the hepatitis C virus (HCV) in laboratory cultures of human cells. The finding, reported in the June 9 issue of Science Express, will allow scientists to study every stage of the HCV life cycle and develop drugs to treat this life-threatening disease that affects more than 170 million people around the world.

"The inability to reproduce aspects of the hepatitis C virus life cycle in cell culture has slowed research progress on this important human pathogen," says senior author Charles M. Rice, Ph.D., Maurice R. and Corinne P. Greenberg Professor and head of the Laboratory of Virology and Infectious Disease at Rockefeller.

"This system lays the foundation for future test tube studies of the virus life cycle and may help in the development of new drugs for combating HCV," adds Rice, who is the scientific director of the Center for the Study of Hepatitis C, a collaborative research and clinical effort of Rockefeller, Weill Medical College of Cornell University, and New York- Presbyterian Hospital

Like all viruses, HCV cannot replicate by itself; instead it takes over the machinery of a host cell to make copies of itself. Much about the life cycle of HCV remains poorly understood because scientists have been unable to reproduce an infectious form of HCV that they can observe in cell cultures. The method developed by Rice and his colleagues, including scientists at the Massachusetts Institute of Technology and the Scripps Research Institute, changes that.

"The hallmark of viruses is their ability to exist in a form outside the host cell capable of infecting new cells," says first author Brett Lindenbach, Ph.D., a postdoctoral fellow in Rice's lab. "Our method replicates and produces virus particles that can infect new cells, initiating replication in them and leading to the production of more virus particles."


'"/>

Source:Rockefeller University


Page: 1 2

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. Researchers reveal the infectious impact of salmon farms on wild salmon
5. Researchers identify target for cancer drugs
6. Researchers discover molecule that causes secondary stroke
7. Researchers find missing genes of ancient organism
8. Researchers trace evolution to relatively simple genetic changes
9. Researchers add new tool to tumor-treatment arsenal
10. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
11. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Researchers create infectious hepatitis virus test tube

(Date:4/14/2015)... , April 14, 2015 NXT-ID, Inc. (NASDAQ: ... authentication company focused on the growing mobile commerce market, ... for the 2015 New York Design Awards under the ... New York City Design Awards are part of a ... over 2,500 ratings from the marketplace, industry and judging ...
(Date:4/8/2015)... 2015  Infinisource, a leading provider of SaaS-based Human ... a leading supplier of biometric identification and security ... most advanced biometrically-enabled time clock, the companies announced ... is setting a bold, new standard for the ... small and mid-size employer. When connected to the ...
(Date:4/2/2015)... 2015 Fingerprint Cards (FPC) has ... from the distributor World Peace Industrial Group (WPI), part ... although the major part of the shipments will take ... by smartphone manufacturers in China . ... the communicated revenue guidance of + 1 000 MSEK for ...
Breaking Biology News(10 mins):NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 110 Million 2
... Houston, Texas May 14, 2010 Scientists studying ... Coast of Louisiana and the city of New Orleans ... from exposure to chemical contaminants. The findings, published in ... , demonstrate how Hurricane Katrina caused significant ecological damage ...
... 13, 2010 -- "Food, Nutrition, Agriculture, and Natural Resource ... of a book chapter written by key staff at ... and Soil Science Society of America. Authors ... Bijl, Science Policy Programs Coordinator, highlight programs and trends ...
... Toronto, ON Invasive species, toxic chemical contamination and ... the challenges being addressed by researchers and government at a ... University of Toronto from Monday, May 17 to Friday, May ... Senior Advisor on the Great Lakes to U.S. Environmental Protection ...
Cached Biology News:New research reveals Hurricane Katrina's impact on ecological and human health 2New research reveals Hurricane Katrina's impact on ecological and human health 3Identifying federal research dollars for ag 2
(Date:4/16/2015)... 2015 Spirax Sarco, the leader ... their newly designed, state-of-the-art website in the first ... effectively promotes the Spirax Sarco brand, company capabilities, ... that a site visitor might be looking for ... industries serviced, the latest company news, careers, and ...
(Date:4/16/2015)... Proove Biosciences , Inc. is ... Contest for the 2015 BIO International Convention. Hosted ... International Convention will take place June 15-18 at the ... of BIO contest, industry leaders will be voting for ... conference. The community voting period began on April 14, ...
(Date:4/16/2015)... The Council for Agricultural Science and ... CAST Communication Award goes to Dr. Channapatna Prakash, ... Alabama. Award nominees must demonstrate an ability to ... use of television, radio, or other social media. ... specialist in the field of plant genetics and ...
(Date:4/16/2015)... 2015 ChemRar High ... and R&D group, and Lancet, Russian Distribution ... and commercialization of new medicines in ... to stimulate the innovative development of the ... http://photos.prnewswire.com/prnh/20150416/739742-a) ,     (Logo: http://photos.prnewswire.com/prnh/20150416/739742-b) , ...
Breaking Biology Technology:Spirax Sarco website has a new look 2Proove Bisociences to Participate in the Buzz of BIO at the 2015 BIO International Convention 2Proove Bisociences to Participate in the Buzz of BIO at the 2015 BIO International Convention 3The 2015 Borlaug CAST Communication Award Goes to Channapatna Prakash 2Lancet and ChemRar High Tech Center Have Announced a Partnership in the Development and Production of Novel Drugs in Russia 2
... "gecko foot" dry adhesive got a new competitor this week ... journal Science by a team of researchers from four U.S. ... of gecko lizards to scurry up walls and cling to ... ability to microscopic branched elastic hairs in their toes that ...
... SAN DIEGO, Oct. 9 CardioDynamics (Nasdaq:,CDIC), the innovator ... financial results for fiscal third quarter 2008., ... Quarter 2007 -- Net ICG sales increased 8% ... International sales increased 35% to $690,000, up from $513,000 ...
... 9 /PRNewswire-FirstCall/ - Dr. Brad Thompson, President,and CEO ... will present a,corporate overview of the Company at ... on Monday, October 13 at 2 p.m. The ... Conference Centre from October,12-14, 2008., About Oncolytics ...
Cached Biology Technology:Dry adhesive based on carbon nanotubes gets stronger, with directional gripping ability 2Dry adhesive based on carbon nanotubes gets stronger, with directional gripping ability 3Dry adhesive based on carbon nanotubes gets stronger, with directional gripping ability 4CardioDynamics Reports Third Quarter 2008 Results, Seventh Consecutive Quarterly Revenue Growth and 15% Year to Date Revenue Increase 2CardioDynamics Reports Third Quarter 2008 Results, Seventh Consecutive Quarterly Revenue Growth and 15% Year to Date Revenue Increase 3CardioDynamics Reports Third Quarter 2008 Results, Seventh Consecutive Quarterly Revenue Growth and 15% Year to Date Revenue Increase 4CardioDynamics Reports Third Quarter 2008 Results, Seventh Consecutive Quarterly Revenue Growth and 15% Year to Date Revenue Increase 5CardioDynamics Reports Third Quarter 2008 Results, Seventh Consecutive Quarterly Revenue Growth and 15% Year to Date Revenue Increase 6Media Advisory - Oncolytics Biotech Inc. to Present at BioPartnering Europe 2
...
... Comments: Ab-1 stains tumor cells ... not other type of germ cell tumors like ... immature teratoma are positive. Luminal and endocrine cells ... lobules of breast are also positive. ...
TP-1 (NDOG1)...
Ras-related C3 botulinum toxin substrate 1...
Biology Products: