Navigation Links
Researchers create infectious hepatitis C virus in a test tube

A team of researchers led by scientists at The Rockefeller University has produced for the first time an infectious form of the hepatitis C virus (HCV) in laboratory cultures of human cells. The finding, reported in the June 9 issue of Science Express, will allow scientists to study every stage of the HCV life cycle and develop drugs to treat this life-threatening disease that affects more than 170 million people around the world.

"The inability to reproduce aspects of the hepatitis C virus life cycle in cell culture has slowed research progress on this important human pathogen," says senior author Charles M. Rice, Ph.D., Maurice R. and Corinne P. Greenberg Professor and head of the Laboratory of Virology and Infectious Disease at Rockefeller.

"This system lays the foundation for future test tube studies of the virus life cycle and may help in the development of new drugs for combating HCV," adds Rice, who is the scientific director of the Center for the Study of Hepatitis C, a collaborative research and clinical effort of Rockefeller, Weill Medical College of Cornell University, and New York- Presbyterian Hospital

Like all viruses, HCV cannot replicate by itself; instead it takes over the machinery of a host cell to make copies of itself. Much about the life cycle of HCV remains poorly understood because scientists have been unable to reproduce an infectious form of HCV that they can observe in cell cultures. The method developed by Rice and his colleagues, including scientists at the Massachusetts Institute of Technology and the Scripps Research Institute, changes that.

"The hallmark of viruses is their ability to exist in a form outside the host cell capable of infecting new cells," says first author Brett Lindenbach, Ph.D., a postdoctoral fellow in Rice's lab. "Our method replicates and produces virus particles that can infect new cells, initiating replication in them and leading to the production of more virus particles."


'"/>

Source:Rockefeller University


Page: 1 2

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. Researchers reveal the infectious impact of salmon farms on wild salmon
5. Researchers identify target for cancer drugs
6. Researchers discover molecule that causes secondary stroke
7. Researchers find missing genes of ancient organism
8. Researchers trace evolution to relatively simple genetic changes
9. Researchers add new tool to tumor-treatment arsenal
10. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
11. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Researchers create infectious hepatitis virus test tube

(Date:2/24/2015)... DUBLIN , Feb. 24, 2015 Research ... announced the addition of the "Global 2D ... offering. The analysts forecast the ... a CAGR of 32.12% over the period 2014-2019 ... devices in non-traditional sectors is one of the ...
(Date:2/19/2015)... DUBLIN , Feb .19, 2015 Research ... announced the addition of the "Military Electro-Optical ... by Sensor Technology, by Platform - Forecast to ... The military electro-optical/infrared systems market is expected ... a CAGR of 7.71%. This report ...
(Date:2/13/2015)... , Feb. 13, 2015 ACT Genomics ... that aims to transform cancer genomic information into ... the company has raised US$ 8 million in the ... in Taipei, Taiwan , ACT ... ACTOnco™. With the aim to implement next generation ...
Breaking Biology News(10 mins):Global 2D Gesture Recognition Market 2015-2019 with Cognitec Systems, CogniVue, eyeSight Mobile Technologies & PointGrab Dominating 2Military Electro-Optical / Infrared Systems (Image Intensification, Laser, Infrared) Market - Forecast to 2020: Featuring Profiles of the Market Leaders on this $16 Billion market 2Military Electro-Optical / Infrared Systems (Image Intensification, Laser, Infrared) Market - Forecast to 2020: Featuring Profiles of the Market Leaders on this $16 Billion market 3ACT Genomics Raises $8 Million in its First Private Funding Round 2
... in the retail nursery industry and with many home ... a variety of plants, conserve water, and reduce the ... lined with polyethylene film on the bottom and covered ... mats help minimize evaporation while allowing water to move ...
... uncharted tenants of the bloodstream known mostly for ... also rally sustained immune system inflammatory responses that ... according to a new report from Johns Hopkins ... aspects of transplant biology," says Craig Morrell, D.V.M., ...
... for Disease Control and Prevention (CDC) shows a ... methicillin-resistant and methicillin-sensitive S. aureus . The ... Central Line-Associated Bloodstream Infections in US Intensive Care ... Nosocomial Infection Surveillance (NNIS) and its successor, the ...
Cached Biology News:Capillary mats labor-saving, economical alternative to hand watering 2Researchers explore new driver of transplant rejection: Platelets 2Researchers explore new driver of transplant rejection: Platelets 3Press statement on new CDC MRSA study from SHEA president 2
(Date:2/27/2015)... 27, 2015   PureTech , a science and ... disruptive products and technologies in the healthcare sector, announced ... CEO and Member of the Board of Directors of ... "It,s has been a pleasure to know Chris for ... will be working together more closely now," said Dr. ...
(Date:2/26/2015)... TORONTO , Feb. 26, 2015 /PRNewswire/ - SQI ... SQIDF), a life sciences company that develops and commercializes ... reported its financial and operational results for the fiscal ... this press release are in Canadian dollars (CAD), unless ... Company continued to win new business from our existing ...
(Date:2/26/2015)... Feb. 26, 2015 DuPont Executive Vice President ... by key research advancements and product launches across the ... of America Merrill Lynch 2015 Global Agriculture Conference. ... building grain supplies the last two years, long-term demand ... pace of the last decade, when demand for corn ...
(Date:2/26/2015)... , Feb. 26, 2015 The healthcare landscape ... ever-changing arena, Frost & Sullivan will host its 20 ... Executive MindXchange , March 8 to 10, at the Hilton ... Calif. This event is a platform ... leaders to discuss industry disruptions and how to succeed in ...
Breaking Biology Technology:Christopher Viehbacher, former CEO of Sanofi, Joins PureTech's Board of Directors 2Christopher Viehbacher, former CEO of Sanofi, Joins PureTech's Board of Directors 3Christopher Viehbacher, former CEO of Sanofi, Joins PureTech's Board of Directors 4SQI Diagnostics Reports First Quarter Financial Results 2SQI Diagnostics Reports First Quarter Financial Results 3SQI Diagnostics Reports First Quarter Financial Results 4SQI Diagnostics Reports First Quarter Financial Results 5SQI Diagnostics Reports First Quarter Financial Results 6DuPont Leader Outlines Path for Growth in Agriculture and Nutrition & Health Segments 2DuPont Leader Outlines Path for Growth in Agriculture and Nutrition & Health Segments 3DuPont Leader Outlines Path for Growth in Agriculture and Nutrition & Health Segments 4DuPont Leader Outlines Path for Growth in Agriculture and Nutrition & Health Segments 5Embrace the Future of Medical Technologies with Frost & Sullivan 2Embrace the Future of Medical Technologies with Frost & Sullivan 3
... 17, 2009 SAN DIEGO, March 10 Neurocrine Biosciences, ... Kevin Gorman, President and Chief Executive Officer of Neurocrine ... 29th Annual Health Care Conference in Boston. The live ... a.m. Eastern Time (ET)/7:15 a.m. Pacific Time (PT). ...
... N.C., March 10 Campbell Alliance, the ... biotech industry, today announced that Ashwin Dandekar, Vice President, ... Oncology Summit USA on March 30 and 31, 2009 ... Dr. Dandekar will also present a workshop at ...
... Market Share Away from Lucentis from 2012 to ... ResourcesWALTHAM, Mass., March 10 Decision Resources, one ... for pharmaceutical and healthcare issues, finds that robust ... degeneration (AMD) market through 2012 will be driven ...
Cached Biology Technology:Campbell Alliance Brand Management Practice to Present at EyeForPharma's Oncology Summit USA and Oncology Market Access Europe Conference 2Campbell Alliance Brand Management Practice to Present at EyeForPharma's Oncology Summit USA and Oncology Market Access Europe Conference 3Robust Annual Growth Through 2012 in the Age-Related Macular Degeneration Market Will Be Driven by Expanding Use of Lucentis in Europe 2Robust Annual Growth Through 2012 in the Age-Related Macular Degeneration Market Will Be Driven by Expanding Use of Lucentis in Europe 3
Recombinant Rat CINC-2 alpha, CF...
RAT ANTI MOUSE F4/80 ANTIGEN:BIOTIN Immunogen: Thioglycollate stimulated peritoneal macrophages from C57/BL mice...
4-Hydroxy-3-nitrophenylacetyl hapten is conjugated to SGG (Sheep gamma globulin) lysine through amide bonds. This product is homologous to NP-BSA....
RAT ANTI MOUSE F4/80 ANTIGEN:BIOTIN Immunogen: Thioglycollate stimulated peritoneal macrophages from C57/BL mice...
Biology Products: