Navigation Links
Researchers create artificial enzyme that mimics the body's internal engine

e are known to be very toxic." The two most deleterious forms of reduced oxygen are superoxide and hydrogen peroxide, which have been implicated in cancer, heart failure, Alzheimer's disease and other illnesses, he added.

The good news is that CcO rarely fails, said Stanford postdoctoral fellow Neal K. Devaraj, whose doctoral dissertation was the basis of the Science paper. According to Devaraj, CcO has more than 99 percent efficiency in transforming oxygen into water.

To understand why CcO is so efficient, Collman's group, led by Stanford research associate Richard Decreau, created an artificial version of the enzyme active site using organic compounds as building materials. The imitation site, which involves an elaborate sequence of 32 chemical steps, was built from scratch and took several years to develop.

The site contains the three active centers found in the naturally occurring enzyme: an organic molecule called phenol, an iron atom and a copper atom. Working together, these three centers provide the four electrons necessary to transform oxygen into water. "How all four electrons are added to oxygen has always been mysterious," Collman said. "Very few people study it. It's quite complex, and it's been broadly ignored."

Each electron is brought to the enzyme one at a time, Collman said: "It's like a bucket brigade in a Western movie." But the electrons are consumed too fast to study individually, he noted. Therefore, the researchers had to invent a technique that supplied electrons to their enzyme model in a slow and continuous way. They solved the problem by attaching the model to a liquid crystalline film on a gold electrode, which provided a nonstop supply of electrons to the model as it transformed oxygen molecules into water-a process called steady turnover.

"The biochemists that study the enzyme typically study single turnover," Collman said. "They let the enzyme have only one oxygen molecule and watch wh
'"/>

Source:Stanford University


Page: 1 2 3

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. Researchers reveal the infectious impact of salmon farms on wild salmon
5. Researchers identify target for cancer drugs
6. Researchers discover molecule that causes secondary stroke
7. Researchers find missing genes of ancient organism
8. Researchers trace evolution to relatively simple genetic changes
9. Researchers add new tool to tumor-treatment arsenal
10. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
11. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
Post Your Comments:
(Date:7/23/2015)... Aware, Inc. (NASDAQ: AWRE ), a leading ... for its second quarter ended June 30, 2015.  ... million, a decrease of 33% compared to $6.8 million in ... quarter of 2015 was $0.3 million, or $0.01 per diluted ... share, in the same period a year ago.  ...
(Date:7/21/2015)... Today, ZTE announced its Android smartphone Axon, ... expected revenues in 2015 that relate to sales of FPC1025 for ... approximately 2,200 MSEK for 2015. Jörgen Lantto, CEO of ... in China and we are proud that ... for Axon , its first ...
(Date:7/21/2015)... Passwords have proven futile for securing ... U.S. Office of Personnel Management breach. Biometric authentication ... but developers and end-users are concerned about how ... Biometrics-as-a-Service provider HYPR Corp. announced today the general ... party integration. A video overview ...
Breaking Biology News(10 mins):Aware, Inc. Reports Second Quarter 2015 Financial Results 2Aware, Inc. Reports Second Quarter 2015 Financial Results 3Aware, Inc. Reports Second Quarter 2015 Financial Results 4Aware, Inc. Reports Second Quarter 2015 Financial Results 5Aware, Inc. Reports Second Quarter 2015 Financial Results 6FPC's Touch Fingerprint Sensor FPC1025 in ZTE's Smartphone Axon 2HYPR Corp. Launches Industry First Biometric Tokenization Platform 2HYPR Corp. Launches Industry First Biometric Tokenization Platform 3HYPR Corp. Launches Industry First Biometric Tokenization Platform 4
... skull-splitting pain. Scientists have found evidence that the headaches ... parts of the brain starved for oxygen and altering ... the work by neuroscientists at the University of Rochester ... , The scientists say the work makes it ...
... new study appearing in the May issue of The ... geologists must account for when examining dinosaur tracks. The ... family of dinosaurs that includes the T. Rex and ... effects of many different types of erosion on these ...
... more than just making pie, according to new data from ... researchers and presented today at a major scientific meeting. ... animals that received powdered tart cherries in their diet had ... the liver, lower oxidative stress and increased production of a ...
Cached Biology News:Mice with a migraine show signs of brain damage 2Mice with a migraine show signs of brain damage 3Mice with a migraine show signs of brain damage 4Mice with a migraine show signs of brain damage 5How to look at dinosaur tracks 2A cherry on top: Tart cherries may alter heart/diabetes factors 2A cherry on top: Tart cherries may alter heart/diabetes factors 3A cherry on top: Tart cherries may alter heart/diabetes factors 4
(Date:7/29/2015)... , July 30, 2015 According ... Market - Growth, Trends & Forecasts (2015-2020), , published by ... US$ 30.25 billion by the end of 2020, with ... accounting for more than 40% of the global market size. ... at a CAGR of 13.7% during the period of (2015-2020). ...
(Date:7/29/2015)... / Japan (Q2 2015: +14% CER / 20% ... high-single-digit growth in China , as well as solid contributions ... Europe / Middle East / ... showed gains in Germany , Turkey ... CER / 49% of sales) grew 11%, excluding U.S. HPV sales, on demand ...
(Date:7/29/2015)...  HealthSouth Corporation (NYSE: HLS ), ... healthcare services, offering both facility-based and home-based post-acute ... the second quarter ended June 30, 2015. ... volume growth in both segments and an 11.0% ... President and Chief Executive Officer of HealthSouth. "While ...
(Date:7/29/2015)... ... July 29, 2015 , ... G-CON Manufacturing, ... launch of their 2nd generation cell therapy POD® design. The 2nd generation portfolio ... also represents a new POD® design. , “G-CON first offered our miniPOD ...
Breaking Biology Technology:Asia Pacific to Dominate the Global Stem Cell Market - Vericel Corporation, Ocata Therpeutics, Athersys Inc., Cryo-Cell International, Geron Corporation, StemCells, Inc. Among the Major Players 2Asia Pacific to Dominate the Global Stem Cell Market - Vericel Corporation, Ocata Therpeutics, Athersys Inc., Cryo-Cell International, Geron Corporation, StemCells, Inc. Among the Major Players 3QIAGEN Reports Results for Second Quarter and First Half of 2015 2QIAGEN Reports Results for Second Quarter and First Half of 2015 3QIAGEN Reports Results for Second Quarter and First Half of 2015 4QIAGEN Reports Results for Second Quarter and First Half of 2015 5QIAGEN Reports Results for Second Quarter and First Half of 2015 6QIAGEN Reports Results for Second Quarter and First Half of 2015 7QIAGEN Reports Results for Second Quarter and First Half of 2015 8QIAGEN Reports Results for Second Quarter and First Half of 2015 9QIAGEN Reports Results for Second Quarter and First Half of 2015 10HealthSouth Reports Results for Second Quarter 2015 2HealthSouth Reports Results for Second Quarter 2015 3HealthSouth Reports Results for Second Quarter 2015 4HealthSouth Reports Results for Second Quarter 2015 5HealthSouth Reports Results for Second Quarter 2015 6HealthSouth Reports Results for Second Quarter 2015 7HealthSouth Reports Results for Second Quarter 2015 8HealthSouth Reports Results for Second Quarter 2015 9HealthSouth Reports Results for Second Quarter 2015 10HealthSouth Reports Results for Second Quarter 2015 11HealthSouth Reports Results for Second Quarter 2015 12HealthSouth Reports Results for Second Quarter 2015 13HealthSouth Reports Results for Second Quarter 2015 14HealthSouth Reports Results for Second Quarter 2015 15HealthSouth Reports Results for Second Quarter 2015 16HealthSouth Reports Results for Second Quarter 2015 17HealthSouth Reports Results for Second Quarter 2015 18HealthSouth Reports Results for Second Quarter 2015 19HealthSouth Reports Results for Second Quarter 2015 20HealthSouth Reports Results for Second Quarter 2015 21HealthSouth Reports Results for Second Quarter 2015 22HealthSouth Reports Results for Second Quarter 2015 23HealthSouth Reports Results for Second Quarter 2015 24HealthSouth Reports Results for Second Quarter 2015 25
... 7 Codexis, Inc. today announced,a licensing agreement with ... product, using a proprietary Codexis,biocatalyst. Teva, the largest ... of this generic product. The product is one ... States. , Under the agreement, ...
... Calif., Jan. 7 Intradigm Corporation, a leading,developer ... that the company has closed the final tranche ... the $2.9 million tranche, with,existing investor, Lilly Ventures, ... the total Series B financing to $21.4 million. ...
... Abaxis, Inc. (Nasdaq: ABAX ), a ... for both the medical and veterinary markets, announced ... agreement for co-exclusive worldwide rights in the field ... for certain technologies pertaining to lateral flow immunoassay ...
Cached Biology Technology:Codexis, Teva in Licensing Agreement Final 2Intradigm Closes Final Tranche of $21.4 Million Series B Financing 2Intradigm Closes Final Tranche of $21.4 Million Series B Financing 3ABAXIS Announces Worldwide Animal Health Licensing Agreement for Rapid Test Technology 2ABAXIS Announces Worldwide Animal Health Licensing Agreement for Rapid Test Technology 3
... Caliper's iLink makes it easy to supply ... instruments. Developed with operator convenience in mind, ... shoot' ease of use. The iLink software ... for assays or sub-assays, that can be ...
... As research demands continue to grow, ... more spectral information has become necessary, especially ... spectral colors. The innovative C1si Confocal Microscope ... speed and spectral capability not available in ...
... LAS-3000 imaging system combines new CCD ... interface, providing significantly improved system sensitivity ... The LAS-3000 provides significantly improved system ... applications including: fluorescence, chemifluorescence, chemiluminescence, and ...
The LAS-3000 imaging system combines new CCD camera technology with a simplified user interface to provide significantly improved system sensitivity with a wide range of modularities. This system is...
Biology Products: