Navigation Links
Researchers add crucial information on how the body's T cells react to parasitic diseases

the Americas, and kills 50,000 of those. The parasite that carries it, T. cruzi, is transmitted to mammals and humans through the bite of several genera of flying, biting insects. What intrigued Tarleton was that T cell response to infection from T. cruzi, while important to the body's ability to fight disease, has remained somewhat cryptic because of the daunting complexity of the processes.

There are actually several kinds of T cells, and the ones Tarleton and his colleagues studied are the cytotoxic T cell, which scientists call CD8+. What they discovered is that the T cell response in T. cruzi is highly focused on a relatively small set of cellular features called "epitopes," which are part of a macromolecule that is recognized by the immune system. The specific epitopes involved are ones encoded by the trans-sialidase (or "ts") family of genes.

"The function of the ts genes is crucial for the parasite," said Tarleton, "because the parasite must have sialic acids to invade cells and infect the host. But since it doesn't have it, it must steal it from the host cells." The problem is that T. cruzi potentially expresses more than a thousand ts genes, and this pool varies from parasite to parasite--making this set of proteins a poor choice for vaccine development, Tarleton said.

The importance of the new research, however, isn't in specifically what happens in T. cruzi and Chagas Disease. Rather, it is a new understanding of how T cells react to infection in all parasitic diseases, including malaria, which may cause as many as 500 million infections and three million deaths annually in humans. The entire area has been little understood because of the almost impenetrable complexity of the problem.

In organisms like viruses and bacteria, which have relatively small genomes, analysis can be more direct; however, understanding the targets of the T cell response in complex pathogens such as T. cruzi requires much more. Scientists mus
'"/>

Source:University of Georgia


Page: 1 2 3

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. Researchers reveal the infectious impact of salmon farms on wild salmon
5. Researchers identify target for cancer drugs
6. Researchers discover molecule that causes secondary stroke
7. Researchers find missing genes of ancient organism
8. Researchers trace evolution to relatively simple genetic changes
9. Researchers add new tool to tumor-treatment arsenal
10. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
11. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
Post Your Comments:
(Date:1/22/2015)... Jan. 13, 2015 Technology Showcase, Hall E -   ... solutions, today announced it will showcase its EyeLock ID technology ... the Department of Energy,s Oak Ridge National Laboratory ... . EyeLock,s iris identity authentication technology is being used to ...
(Date:1/22/2015)... 21, 2015  Analyst Report Issued by Small Cap IR. In ... that planet-wide, transactions at merchants on the leading payment cards ... of credit, debit, and prepaid cards reached 6.54 billion.  Eight ... fraudulent card usage in 2012, and credit and debit card ...
(Date:12/24/2014)... its launch in December 2014, the 1U™ app ... trying to remember their usernames and passwords through replacing the ... To assist people who have struggled to remember usernames and ... and focuses on redefining identity, announced today that it is ...
Breaking Biology News(10 mins):EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 2EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 3$4.80 Near Term Price Target with "Buy" given by CapRock Research for NXT-ID, Inc. (NASDAQ: NXTD) issued by Small Cap IR 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 3
... salamander,s natural ability to grow back severed appendages lead to ... With the help of a $6.25 million U.S. Department of ... and Mary Wright Ebaugh chair in science and engineering, will ... - Irvine and the University of Kentucky to identify the ...
... carried out by the teams of Jordi Surralls, Universitat ... Raya, Centre for Regenerative Medicine of Barcelona (CMRB); and ... Research (CIEMAT), has resulted in the generation of blood ... disease known as Fanconi anemia. The process is based ...
... underrepresented in the applicant pool for faculty positions in math, ... apply are interviewed and hired at rates equal to or ... the National Research Council. Similarly, women are underrepresented among ... tenure at the same or higher rates than men. ...
Cached Biology News:Tulane receives grant to study limb regeneration 2Genetically corrected blood cells obtained from skin cells from Fanconi anemia patients 2Women faring well in hiring process for science faculty jobs at research universities 2Women faring well in hiring process for science faculty jobs at research universities 3Women faring well in hiring process for science faculty jobs at research universities 4
(Date:1/22/2015)... 2015 Controlled Substance Compliance Services (CSCS), ... companies check the legal requirements around using controlled substances ... , As their international operations expand and become ... solutions built as a result of the first phase ...
(Date:1/22/2015)... Jersey , 22 de enero de 2015  El Dr. ... hoy su llamada a nominaciones para 2015. Este prestigioso ... hecho, o tiene el potencial para hacer, contribuciones destacadas ... se aceptarán hasta el 15 de marzo de 2015 ...
(Date:1/22/2015)... , Jan. 22, 2015   GenoSpace , a precision medicine ... to enable the broad use of genomic, imaging and other ... appointment of Michelle Munson , CEO of Aspera, an ... Logo - http://photos.prnewswire.com/prnh/20150122/170713 "We ...
(Date:12/24/2014)... 2014  United Therapeutics Corporation (NASDAQ: UTHR ) ... ) has submitted a pre-market approval application to the ... of Medtronic,s SynchroMed ® II implantable drug infusion ... United Therapeutics, Remodulin ® (treprostinil) Injection delivered intravenously ...
Breaking Biology Technology:Global Compliance Service for Controlled Substances to Expand to China 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 3El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 4GenoSpace Expands Board with Appointment of Michelle Munson 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 3United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 4
... ... energy efficient products that save money in an uncertain economy. , ... Glenview, IL (Vocus) Feb. 17, 2010 -- In a ... its Green Program. , , ,Our goal is to have no waste, and we are ...
... inexpensive, fast, accurate DNA test that reveals a person,s risk ... thanks to technology developed at the University of Edinburgh. ... person,s genetic code at critical points along the DNA chain. ... drop of saliva. Tiny differences or omissions in ...
... 2010) A tiny scaffold-like titanium structure of Nanonets ... faster, lighter and longer-lasting Lithium-ion batteries, according to a ... anode material using nanotechnology. The web-like Nanonets developed ... Wang offer a unique structural strength, more surface area ...
Cached Biology Technology:Abt Electronics Becoming the Green Giant of Independent Retailers 2Abt Electronics Becoming the Green Giant of Independent Retailers 3Silicon-coated nanonets could build a better lithium-ion battery 2
Rad 50 Immunogen: c-terminal mRad 50 (604 amino acids). Storage: 4 C...
...
... Materials for 15-20 enhancements when used as directed, ... Enhancement System is designed to amplify the desired signal ... for evaluating proteins with low expression., ... to blocking the membrane; 1x solution; 250 ml, ...
Applications: Western blotting ...
Biology Products: