Navigation Links
Researchers Closer To Helping Hearing-Impaired Using Stem Cells

Researchers at Indiana University School of Medicine are several steps closer to the day when a profoundly deaf patient’s own bone marrow cells could be used to let him or her hear the world.

The IU group, led by Eri Hashino, Ph.D., was able to transform, in the laboratory, stem cells taken from adult bone marrow into cells with many of the characteristics of sensory nerve cells -- neurons -- found in the ear. The results suggest that these adult stem cells could be used to treat deaf patients in the future, said Dr. Hashino, an associate professor and Ruth C. Holton Scholar in the Department of Otolaryngology -- Head and Neck Surgery.

The cells used in the research are called marrow stromal cells -- a type of stem cell from which fat, bone and cartilage normally develop.

“We were interested in marrow stromal cells because of their potential for use in autologous cell-based therapy,?said Dr. Hashino, referring to cell transplantation in which a patient’s own cells are used in treatment. The cells can be collected easily and kept alive in the laboratory until needed, she said.

Other researchers had previously shown that the marrow stromal cells could be induced to transform into neuronal cells, but it wasn’t clear whether, or how, the cells could be further transformed into useful specialized neurons.

In a two-step process, Dr. Hashino and her colleagues first cultivated mouse marrow stromal cells with chemicals known to encourage stems cells to change into primitive neurons. The bone marrow cells took the shape and other characteristics of neurons. Next, they exposed the cells to two molecules that are secreted from nearby tissues of the ear during embryonic development. The two molecules -- known as Sonic hedgehog and retinoic acid -- together caused the marrow stromal cells to further develop into cells with many of the characteristics of auditory neurons, such as the presence of specific genes and proteins.

Dr. Hashi no said she and her colleagues are beginning new experiments to test the feasibility of marrow stromal cell transplantation to stimulate the growth of the nerve cells that are often missing from the inner ears of patients with profound hearing loss.

“Sonic hedgehog and retinoic acid are molecules found in embryonic tissues, but not in adult tissues,?said Dr. Hashino. “This suggests that treating marrow-derived stem cells with these molecules before transplantation might greatly enhance the possibility that the process would result in development of specific sensory neurons.?/p>

The research was published March 18 in the online early edition of the Proceedings of the National Academy of Sciences, and is scheduled to appear in the print edition of the journal March 29.


'"/>

Source:Indiana University School Of Medicine


Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. Researchers reveal the infectious impact of salmon farms on wild salmon
5. Researchers identify target for cancer drugs
6. Researchers discover molecule that causes secondary stroke
7. Researchers find missing genes of ancient organism
8. Researchers trace evolution to relatively simple genetic changes
9. Researchers add new tool to tumor-treatment arsenal
10. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
11. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/1/2016)... Rising sales of consumer electronics ... intuitive gesture control market size ... consumer electronics coupled with new technological advancements to drive ... through 2020   --> ... advancements to drive global touchfree intuitive gesture control market ...
(Date:2/1/2016)... , Feb. 1, 2016  Wocket® smart wallet ( www.wocketwallet.com ) announces ... personality, Joey Fatone . Las Vegas , ... --> Las Vegas , where Joey appeared ... The new video ad was filmed at the Consumer Electronics Show ... the Wocket booth to meet and greet fans. ...
(Date:1/27/2016)...  Rite Track, Inc. a leading semiconductor equipment and ... Ohio announced today the acquisition of PLUS LLC. ... Austin, Texas , will significantly bolster ... installations and technical support offerings for TEL Track Systems. ... "PLUS has provided world class service including refurbishment, enhancements ...
Breaking Biology News(10 mins):
(Date:2/11/2016)... and GERMANTOWN, Maryland , February 11, ... Standard: QIA) today announced the introduction of more than ... profiling, expanding QIAGEN,s portfolio of Sample to Insight solutions ... select from over 20,000 human genes and lncRNA to ... cellular phenotypes and disease processes. --> QGEN ...
(Date:2/11/2016)... -- Wellcentive today announced it has been selected by FamilyCare ... community care organization (CCO) with more than 130,000 ... and care management solutions and services. Wellcentive,s capabilities ... managers, analysts and care managers while providing insight ... members. Oregon . ...
(Date:2/11/2016)... BEACH, Florida , February 11, 2016 /PRNewswire/ ... PositiveID Corporation ("PositiveID" or "Company") (OTCQB: PSID), ... diagnostics, announced today that its Thermomedics subsidiary, which ... progress on its growth plan in January 2016, ... products distributors, increasing sequential monthly sales growth, and ...
(Date:2/11/2016)... ... 11, 2016 , ... Global Stem Cells Group, ... Global Stem Cells Network (GSCN) to distribute exosome injection and other biological products ... Costa Rica, Dominican Republic, Colombia, Argentina, Nicaragua, Panama, El Salvador, Venezuela, Peru, Ecuador, ...
Breaking Biology Technology: