Navigation Links
Researchers Closer To Helping Hearing-Impaired Using Stem Cells

Researchers at Indiana University School of Medicine are several steps closer to the day when a profoundly deaf patient’s own bone marrow cells could be used to let him or her hear the world.

The IU group, led by Eri Hashino, Ph.D., was able to transform, in the laboratory, stem cells taken from adult bone marrow into cells with many of the characteristics of sensory nerve cells -- neurons -- found in the ear. The results suggest that these adult stem cells could be used to treat deaf patients in the future, said Dr. Hashino, an associate professor and Ruth C. Holton Scholar in the Department of Otolaryngology -- Head and Neck Surgery.

The cells used in the research are called marrow stromal cells -- a type of stem cell from which fat, bone and cartilage normally develop.

“We were interested in marrow stromal cells because of their potential for use in autologous cell-based therapy,?said Dr. Hashino, referring to cell transplantation in which a patient’s own cells are used in treatment. The cells can be collected easily and kept alive in the laboratory until needed, she said.

Other researchers had previously shown that the marrow stromal cells could be induced to transform into neuronal cells, but it wasn’t clear whether, or how, the cells could be further transformed into useful specialized neurons.

In a two-step process, Dr. Hashino and her colleagues first cultivated mouse marrow stromal cells with chemicals known to encourage stems cells to change into primitive neurons. The bone marrow cells took the shape and other characteristics of neurons. Next, they exposed the cells to two molecules that are secreted from nearby tissues of the ear during embryonic development. The two molecules -- known as Sonic hedgehog and retinoic acid -- together caused the marrow stromal cells to further develop into cells with many of the characteristics of auditory neurons, such as the presence of specific genes and proteins.

Dr. Hashi
'"/>

Source:Indiana University School Of Medicine


Page: 1 2

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. Researchers reveal the infectious impact of salmon farms on wild salmon
5. Researchers identify target for cancer drugs
6. Researchers discover molecule that causes secondary stroke
7. Researchers find missing genes of ancient organism
8. Researchers trace evolution to relatively simple genetic changes
9. Researchers add new tool to tumor-treatment arsenal
10. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
11. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Researchers Closer Helping Hearing Impaired Using Stem Cells

(Date:4/23/2014)... Wash. -- Like a hungry diner ripping open a ... into electricity must tear open a hydrogen molecule. Now ... holding onto the two halves of its hydrogen feast. ... how to make the catalyst work better for alternative ... scientists have shown precisely where the hydrogen halves end ...
(Date:4/23/2014)... A team of researchers in Korea who ... brains of nonhuman primates and assessed cell survival ... that the hNSCs had differentiated into neurons at ... The study will be published in a future ... currently freely available on-line as an unedited early ...
(Date:4/23/2014)... found evidence of an interaction between prenatal smoking ... in children, especially in girls. , "The interesting ... prenatal smoking will have behavioral problems. Some ... Assistant Professor at Sam Houston State University, College ... study. "One possible explanation for this is ...
Breaking Biology News(10 mins):Halving hydrogen 2Halving hydrogen 3Halving hydrogen 4Study finds long-term survival of human neural stem cells transplanted into primate brain 2Genetics risk, prenatal smoking may predict behavioral problems 2
... likely require an old ally Mother Nature and ... for cutting greenhouse gas emissions 20% by 2020, according ... says that despite rising population and affluence, the EU ... will likely require more than energy savings, new technologies ...
... Australia now have greater access to the Japanese market ... of Primary Industries (DPI). Trials undertaken at NSW ... at temperatures of 2 or 3C can effectively kill ... days. Cold treatment at these temperatures provides greater ...
... still some places available on two international workshops for ... Netherlands) is organizing at the start of 2008. The ... sanitary engineering,. The two workshops are to be held ... or attended seperately. The Delft University of Technology ...
Cached Biology News:European Union forests expanding, absorbing carbon at surprisingly high rate: study 2European Union forests expanding, absorbing carbon at surprisingly high rate: study 3Cold treatment opens doors for citrus exports to Japan 2
(Date:1/14/2014)... DC (PRWEB) January 14, 2014 Carahsoft ... for Thursday, January 23, 2014 at 2pm EST (11am ... Knowledge.” The topic focuses on how technology can turn ... critical decisions for government agencies. The online webinar will ...
(Date:1/14/2014)... pet owners drew up their lists of New Year,s resolutions for ... of my furry companion." Nowadays there are pet salons, dog and ... take the little canine or feline darlings along wherever mommy or ... pricey toys at the pet store. But anyone who has ever ...
(Date:1/14/2014)... DIEGO and BETHESDA, Md. ... are joining together with two institutes from the National ... reliable tools for bringing safer, more effective treatments to ... the National Center for Advancing Translational Sciences (NCATS) and ...
(Date:1/14/2014)... 14, 2014  RXi Pharmaceuticals Corporation (OTCQX: RXII), a ... innovative therapies addressing major unmet medical needs using ... Notice of Allowance from the United States Patent ... compounds (sd-rxRNA®), for the treatment of fibrosis. The ...
Breaking Biology Technology:Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2New Year's Resolution: Give Pets the Gift of Top-Notch Health Care 2Organovo Announces Collaboration with National Institutes of Health 2Organovo Announces Collaboration with National Institutes of Health 3RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 2RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 3
... Crosse, Wis. -- Firstlogic Inc. , a ... Corp. approved technology from Firstlogics Information Quality ... ,Oracle Warehouse Builder is a business intelligence integration ... allows users to design their business intelligence application ...
... medial errors, improve patient safety and run a ... to automate the costly processes of data collection, ... 5 percent of healthcare organizations research outcome and ... revenue enhancements and quality of life improvements associated ...
... reducing surgery delays and controlling instrument and staff costs ... trays by using a new surgical instrument management system ... ,Gundersen Lutheran operates a teaching hospital with 325 licensed ... practices, community clinics, eye clinics and pharmacies. It has ...
Cached Biology Technology:Real-Time Data Warehouse Benefits Healthcare Providers 2Real-Time Data Warehouse Benefits Healthcare Providers 3Gunderson Lutheran Implements Instrument Management Systems 2
... WinList come straight from the folks who ... automatic region positioning, N-Stat regions, and presentation-quality ... thoughtful conversations, and careful design. Of course, ... are still there, too. WinList leads the ...
Insect Cell Lysis Buffer 50 ml...
Recognizes the VZV nucleocapsid by indirect immunofluorescence and immunoprecipitation. Shows cross-reactivity to HSV....
Rabbit polyclonal to Orexin Prepro ( Abpromise for all tested applications). entrezGeneID: 3060 SwissProtID: O43612...
Biology Products: