Navigation Links
Researcher to study astronaut bone loss for space biology agency

ght. "This makes their rehabilitation risky, because, like astronauts who have returned to earth, they are predisposed to fractures."

Long's research project will focus on the relationship between three substances: insulin-like growth factor-1 (IGF-1), a chemical produced in bone and other organs that promotes the growth of bone and cartilage; IGF-1 receptor, which resides in bone cells and enables them to respond to IGF-1; and beta-3 integrin, a protein that among other roles promotes the function of IGF-1 receptor.

Long's and Bikle's hypothesis is that during prolonged weightlessness, beta-3 integrin production decreases, which in turn diminishes the function of IGF-1 receptor in bone. Without its receptor, IGF-1 has been shown by researchers to be ineffective. The result is a steep drop in the creation of new bone cells, leading to bone loss.

To investigate the hypothesis, Long will take a two-pronged research approach. In the first part, he will study a model of skeletal loading and unloading in human bone cell culture. In the second part, skeletally unloaded rats will be treated with IGF-1 and reloaded on a regular cycle –?much as astronauts might regularly engage in weight-bearing exercise while in orbit –?in order to stimulate integrin production and enhance or recover IGF-1 receptor function. The IGF-1 will act as a signaling device to allow Long to measure the strength of the interaction between integrins and IGF-1 receptor.

"Understanding this interaction, and the role it plays in how bones respond to mechanical forces, will allow interventions to protect the bones of astronauts," Long says.

"We hope to find that we can manipulate the IGF-1 system to accelerate rehabilitation, not only among astronauts but among a broad range of patients," says Bikle. "We might also learn how to prevent bone loss from taking place."

Long concludes, "I am excited and honored to contribute to our nation's efforts
'"/>

Source:University of California - San Francisco


Page: 1 2 3

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. Researchers reveal the infectious impact of salmon farms on wild salmon
5. Researchers identify target for cancer drugs
6. Researchers discover molecule that causes secondary stroke
7. Researchers find missing genes of ancient organism
8. Researchers trace evolution to relatively simple genetic changes
9. Researchers add new tool to tumor-treatment arsenal
10. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
11. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Researcher study astronaut bone loss for space biology agency

(Date:2/9/2015)... 9, 2015  Lintec of America recently announced an ... nanotube (CNT) macrostructures, including sheets, yarns and ribbons, developed ... Leveraging the vast industrial resources of the global ... , Lintec of America is forming the Nano-Science and ... , focusing on scaling up the manufacturing and commercialization ...
(Date:2/5/2015)... , Jan. 26, 2015   Epic Sciences , ... cancer, today announced that Murali Prahalad , Ph.D., president ... Medicine World Conference (PMWC) 2015: Silicon Valley, which is ... Mountain View, Calif. on January 26-28, 2015. ... Come of Age as Biomarkers." Last year, Epic Sciences was ...
(Date:2/5/2015)... 2015 New Market Research Reports ... Forecasts To 2020 has Been Added to GrandViewReseach.com Report ... expected to reach USD 5.10 billion by 2020, according ... IR cameras help identify the site of tissue damage ... surging demand in medical imaging applications. They have been ...
Breaking Biology News(10 mins):Lintec announces exclusive license to commercialize innovative carbon nanotube technology from the University of Texas at Dallas 2Lintec announces exclusive license to commercialize innovative carbon nanotube technology from the University of Texas at Dallas 3Lintec announces exclusive license to commercialize innovative carbon nanotube technology from the University of Texas at Dallas 4Epic Sciences to Present at Personalized Medicine World Conference 2015 on the Use of Circulating Tumor Cells as Cancer Biomarkers 2IR Camera Market Worth $5.10 Billion By 2020: Grand View Research, Inc. 2IR Camera Market Worth $5.10 Billion By 2020: Grand View Research, Inc. 3
... SAN FRANCISCO -- In 2011, researchers at the California Academy ... The new species include 72 arthropods, 31 sea slugs, 13 fishes, ... were described by more than a dozen Academy scientists along with ... plenty of places to explore and things to discover on Earth, ...
... A comprehensive framework to encourage and facilitate the sharing ... The 24 recommendations of the GBIF Data Publishing Framework ... BMC Bioinformatics . Some of the measures ... by GBIF and others, including the publication of ,data ...
... Jyrki Ltjnen from VTT Technical Research Centre of Finland, ... of Alzheimer,s disease. The tool compares measurements of a ... databases and provides a simple index about the severity ... tool improves the accuracy of diagnosis and clinicians, confidence ...
Cached Biology News:140 new species described by California Academy of Sciences in 2011 2140 new species described by California Academy of Sciences in 2011 3140 new species described by California Academy of Sciences in 2011 4New biodiversity data publishing framework proposed 2New biodiversity data publishing framework proposed 3From heterogeneous patient measurements towards earlier diagnosis in Alzheimer's disease 2
(Date:2/27/2015)... SAN DIEGO , Feb. 27, 2015  Pfenex ... in the development of biosimilar therapeutics, today announced that ... San Francisco Marriott Marquis on March 2 nd ... will participate on a panel discussing the current state ... World of Biosimilars . For more ...
(Date:2/27/2015)... Feb. 27, 2015   PureTech , a science ... commercializing disruptive products and technologies in the healthcare sector, ... former CEO and Member of the Board of Directors ... "It,s has been a pleasure to know Chris ... we will be working together more closely now," said ...
(Date:2/26/2015)... 2015 /PRNewswire/ - SQI Diagnostics Inc. ("SQI" or the ... that develops and commercializes proprietary technologies and products for ... results for the fiscal first quarter ended December  31, ... Canadian dollars (CAD), unless otherwise stated. ... business from our existing customers and add to our ...
(Date:2/26/2015)... FT. LAUDERDALE, Fla. , Feb. 26, 2015 /PRNewswire/ ... discussed growth priorities driven by key research advancements ... Health segments at today,s Bank of America Merrill Lynch ... worldwide met the challenge of building grain supplies the ... expected to continue at the pace of the last ...
Breaking Biology Technology:Christopher Viehbacher, former CEO of Sanofi, Joins PureTech's Board of Directors 2Christopher Viehbacher, former CEO of Sanofi, Joins PureTech's Board of Directors 3Christopher Viehbacher, former CEO of Sanofi, Joins PureTech's Board of Directors 4SQI Diagnostics Reports First Quarter Financial Results 2SQI Diagnostics Reports First Quarter Financial Results 3SQI Diagnostics Reports First Quarter Financial Results 4SQI Diagnostics Reports First Quarter Financial Results 5SQI Diagnostics Reports First Quarter Financial Results 6DuPont Leader Outlines Path for Growth in Agriculture and Nutrition & Health Segments 2DuPont Leader Outlines Path for Growth in Agriculture and Nutrition & Health Segments 3DuPont Leader Outlines Path for Growth in Agriculture and Nutrition & Health Segments 4DuPont Leader Outlines Path for Growth in Agriculture and Nutrition & Health Segments 5
... 2009 at 4:30 p.m. Eastern TimeBOTHELL, WA, and ... ("OncoGenex" or the "Company") (NASDAQ: OGXI ... three months ended March 31, 2009 and reviewed ... 2009. , The following consolidated results reflect the ...
... 6 Spectros Corporation (Portola Valley, CA) filed ... Scientific (NYSE: TMO ), alleging infringement ... 3300 product. Spectros invented and commercialized solid-state, broadband, ... and incorporated these into its flagship T-Stat product, ...
... Calif., May 6 Nektar Therapeutics (Nasdaq: NKTR ... ended March 31, 2009. Net loss for the quarter ended ... compared to net loss of $40.7 million or $0.44 per ... made improvements to its operating efficiencies as compared to a ...
Cached Biology Technology:OncoGenex Reports First Quarter Financial Results 2OncoGenex Reports First Quarter Financial Results 3OncoGenex Reports First Quarter Financial Results 4OncoGenex Reports First Quarter Financial Results 5OncoGenex Reports First Quarter Financial Results 6Spectros Corporation Protects Its Cool White LED Spectroscopy Technology Against Alleged Infringement by Thermo Fisher Scientific 2Nektar Therapeutics Reports First Quarter 2009 Financial Results 2Nektar Therapeutics Reports First Quarter 2009 Financial Results 3Nektar Therapeutics Reports First Quarter 2009 Financial Results 4Nektar Therapeutics Reports First Quarter 2009 Financial Results 5Nektar Therapeutics Reports First Quarter 2009 Financial Results 6Nektar Therapeutics Reports First Quarter 2009 Financial Results 7Nektar Therapeutics Reports First Quarter 2009 Financial Results 8Nektar Therapeutics Reports First Quarter 2009 Financial Results 9
... siTrio siRNA --- a cocktail of ... gene of interestis our most popular product. ... than 75% knockdown of your target gene ... siRNA for transfection and confirmation of optimal ...
... siRNA --- a cocktail of 3 siRNAs ... interestis our most popular product. The siTrio ... knockdown of your target gene when used ... transfection and confirmation of optimal transfection with ...
... This kit #27295 has improved stability and ... improved kit not only has overcome this problem ... first, we have changed the formulation of HRP ... X 1). By this change, the stability of ...
... EIA kit is a complete assay system ... (1,25D) in human serum or plasma. The ... found in the IDS 1,25D RIA followed ... comes with ready to use reagents, no ...
Biology Products: