Navigation Links
Research to spotlight carbon monoxide benefits

Scientists at the University of York have won a grant of £110,000 to investigate potential uses of carbon monoxide in treating disease.

Dr Jason Lynam and Dr Ian Fairlamb, of the University's Department of Chemistry, have been awarded the funding by the Leverhulme Trust for a three-year study into the use of metal compounds for the controlled release of carbon monoxide into the bloodstream.

Carbon monoxide is an anti-inflammatory, and they want to explore its potential in treating high blood pressure, heart disease and possibly cancer. The project builds on a study conducted by Roberto Motterlini (Northwick Park Hospital in London) and Professor Brian Mann (University of Sheffield), and preliminary studies conducted in York, supported by funds from the University and Engineering and Physical Sciences Research Council (EPSRC).

Dr Fairlamb said: "You can use certain carbon monoxide molecules to elicit a whole range of biological effects. Carbon monoxide causes vasorelaxation and is produced naturally as a result of the breakdown of haemoglobin. This can be seen in the healing process of a bruise, where various colour changes indicate the degradation of haemoglobin and release of carbon monoxide. The slow release of carbon monoxide reduces blood pressure for someone who has angina, for instance.

"This work is very much in its infancy. We became involved because some of our organometallic compounds, which carry carbon monoxide, were showing potential to release carbon monoxide slowly in a controlled manner. They degrade to give benign non-toxic products which do not target immune response."

Dr Lynam added: "We don't want to administer carbon monoxide in its normal toxic gaseous form; rather we want to develop molecules that will release it in a sort of slow trickle feed. We aim to make tuneable compounds which allow you to alter the rate at which carbon monoxide is released, which could be important in different bioapplica tions.

"We are adopting a complementary approach to the design of these molecules using the natural interface between organic and inorganic chemistry."

The project will examine the physical and electronic characteristics of potentially suitable compounds and identify those which are absorbed best by the body with the aim of starting clinical studies in three years' time.
'"/>

Source:University of York


Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Quantum Dots Research Leads to New Knowledge about Protein Binding in Plants
3. Researchers find how protein allows insects to detect and respond to pheromones
4. Researchers Uncover Key Step In Manufacture of Memory Protein
5. Research advances quest for HIV-1 vaccine
6. Research on Worms Yields Clues on Aging
7. Researchers reveal the infectious impact of salmon farms on wild salmon
8. Researchers identify target for cancer drugs
9. Weill Cornell Research Reveals Secrets Of Trafficking Within Cells
10. Researchers discover molecule that causes secondary stroke
11. Researchers find missing genes of ancient organism

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/16/2017)... 16, 2017  Veratad Technologies, LLC ( www.veratad.com ), ... and identity verification solutions, announced today they will participate ... May 15 thru May 17, 2017, in ... Trade Center. Identity impacts the lives ... today,s quickly evolving digital world, defining identity is critical ...
(Date:5/6/2017)... SINGAPORE , May 5, 2017 ... has just announced a new breakthrough in biometric ... that exploits quantum mechanical properties to perform ... new smart semiconductor material created by Ram Group ... across finance, entertainment, transportation, supply chains and security. ...
(Date:4/19/2017)... York , April 19, 2017 ... as its vendor landscape is marked by the presence ... market is however held by five major players - ... Together these companies accounted for nearly 61% of the ... the leading companies in the global military biometrics market ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... BioMedGPS announces ... addition of its newest module, US Hemostats & Sealants. , SmartTRAK’s US Market ... hemostats, fibrin sealants, synthetic sealants and biologic sealants used in surgical applications. BioMedGPS ...
(Date:10/11/2017)... YORBA LINDA, CA (PRWEB) , ... October 11, ... ... adapted to upregulate any gene in its endogenous context, enabling overexpression experiments and ... activation (CRISPRa) system with small RNA guides is transformative for performing systematic gain-of-function ...
(Date:10/11/2017)... a leading provider of patient support solutions, has announced the ... which will launch this week. The VMS CNEs will address ... enhance the patient care experience by delivering peer-to-peer education programs ... to help women who have been diagnosed and are being ... ...
(Date:10/11/2017)... ... October 11, 2017 , ... Singh Biotechnology today announced ... to SBT-100, its novel anti-STAT3 (Signal Transducer and Activator of Transcription 3) B ... to cross the cell membrane and bind intracellular STAT3 and inhibit its function. ...
Breaking Biology Technology: