Navigation Links
Research team identifies new Alzheimer's gene

A study comparing more genetic markers in the DNA of people with and without Alzheimer’s disease than ever before has enabled researchers to identify a common gene that appears to increase a person’s risk for developing Alzheimer’s disease. The finding, announced today by researchers at the Translational Genomics Research Institute (TGen), Banner Alzheimer’s Institute, Kronos Science Laboratory and their collaborative partners, suggests that the gene — called GAB2 — modifies an individual’s risk when associated with other genes, including APOE4. The study results appear in the June 7 issue of the prestigious peer-reviewed journal, Neuron.

Alzheimer’s disease is the most common form of disabling memory and thinking problems in older people. The progressive neurological disorder afflicts an estimated 5 million Americans, a number expected to triple by 2050.

“We have entered a new era in medical research. Today’s technologies permit us to survey a sufficient number of letters throughout the human genome to provide a clearer picture of how life works and ultimately allow better clinical management of patients,” said Dr. Dietrich Stephan, Director of TGen’s Neurogenomics Division and the paper’s senior author, “These new, robust tools may eventually allow us to improve our ability to diagnose Alzheimer’s disease, even before it strikes”

To date, the most significant gene found to predispose an individual to late onset Alzheimer’s (LOAD) has been APOE4. In this latest study, researchers from seven organizations contributed to the genome-wide scan using Affymetrix microarray technology. The team screened the DNA from 1,400 individuals who had been clinically assessed with Alzheimer’s prior death, and simultaneously examined more than 500,000 SNPs or genetic variations to characterize and confirm additional LOAD susceptibility genes. The search revealed GAB2.

Based on the genetics of this and other neuroscientific findings, researche
'"/>

Source:The Translational Genomics Research Institute


Page: 1 2 3

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Quantum Dots Research Leads to New Knowledge about Protein Binding in Plants
3. Researchers find how protein allows insects to detect and respond to pheromones
4. Researchers Uncover Key Step In Manufacture of Memory Protein
5. Research advances quest for HIV-1 vaccine
6. Research on Worms Yields Clues on Aging
7. Researchers reveal the infectious impact of salmon farms on wild salmon
8. Researchers identify target for cancer drugs
9. Weill Cornell Research Reveals Secrets Of Trafficking Within Cells
10. Researchers discover molecule that causes secondary stroke
11. Researchers find missing genes of ancient organism
Post Your Comments:
(Date:11/21/2008)...d river currents could be a new, reliable and affo...Michigan engineer has made a machine that works li...ns in fluid flows into clean, renewable power. , ...blished in the current issue of the quarterly Jou.... , VIVACE is the first known device that could ...
(Date:11/21/2008)...er, Department of Plant Biology and Biotechnology ...enhagen, has been granted the Danisco Award 2008. ...nt research into secondary metabolites, which are ...lants. In particular, her research has focused on...f glucosinolates in cruciferous plants. , The p...
(Date:11/20/2008)...ming increasingly aware of toxic chemical exposure... in some baby bottles and lead in some toys, women... with personal chemical exposure and related adver...December issue of the Journal of Health and Socia...ution with large-scale contamination and environme...
(Date:11/20/2008)...n floor made by giant deep-sea single-celled organ...ary origin of animals, says biologist Mikhail "Mis..., Matz and his colleagues recently discovered th... the ocean floor near the Bahamas. This is the fir... make such animal-like traces. , The finding is ...
Breaking Biology News(10 mins):'Fish technology' draws renewable energy from slow water currents 2'Fish technology' draws renewable energy from slow water currents 3The Danisco Award 2008 goes to D.Sc. Barbara Ann Halkier from Faculty of Life Sciences, Copenhagen 2Pollution at home lurks unrecognized, instead attributed to large-scale environmental disasters 2Discovery of giant roaming deep sea protist provides new perspective on animal evolution 2Discovery of giant roaming deep sea protist provides new perspective on animal evolution 3Alba Therapeutics Announces Phase IIb Clinical Trial for Oral AT 1001 for the Treatment of Celiac Disease 326 1Alba Therapeutics Announces Phase IIb Clinical Trial for Oral AT 1001 for the Treatment of Celiac Disease 326 2Hushed Genes Might Mean Higher Lung Cancer Risk 1597 1Hushed Genes Might Mean Higher Lung Cancer Risk 1597 2Early Human Like Skeletons Are First Outside of Africa 1595 1Early Human Like Skeletons Are First Outside of Africa 1595 2Early Human Like Skeletons Are First Outside of Africa 1595 3Stem cells derived from adult testes produce wide range of tissue types 1593 1Stem cells derived from adult testes produce wide range of tissue types 1593 2Stem cells derived from adult testes produce wide range of tissue types 1593 3Stem cells derived from adult testes produce wide range of tissue types 1593 4
...ic bacteria on uncooked poultry products varies by...tic use in production, according to researchers at...th. Their study is the first to directly compare b... U.S. supermarkets from food producers who use ant... study focused on antibiotic resistance, specifica...
...g iron-overload disorders have made the unexpected...the highest levels of iron in their blood of all r...ls who develop hemochromatosis/iron overload absor...ments ingested. The abnormality affects many peopl...mes causes organ damage when severe iron depositio...
...le species within a community and are commonly tra...n is often associated with pathogen emergence and ... for humans, wildlife, and species of agricultural...ease or West Nile encephalitis that infect multipl...heir transmission rate is often thought to depend ...
...ealthy mammals that flit about in the night sky, a... never before seen in bats, according to a recent ...mmon vampire bats of Central and South America beh..., in that they like to walk around on the ground; ...alk. But researchers in Cornell,s College of Veter...
Other Biology News:Drug-resistant bacteria on poultry products differ by brand 2Drug-resistant bacteria on poultry products differ by brand 3Surprising findings reported about iron overload 2Surprising findings reported about iron overload 3A new study examines how shared pathogens affect host populations 2Vampire bats keep out of trouble by running 2
(Date:11/21/2008)...20 years of commercial life sciences sales experie...RNewswire/ -- Cyntellect, a privately-held life sc...ialization of live cell analysis and manipulation ...re Lubarsky as the Company,s Director of Sales - N...les of Cyntellect,s cell purification and cell hea...
(Date:11/21/2008)...Newswire-FirstCall/ -- Intellect Neurosciences, I...utical company focused on development of disease-m...prevention of Alzheimer,s disease released today t...l Chain, its Chairman and CEO. , , Dear Sh... as Chairman and CEO of Intellect Neurosciences In...
(Date:11/20/2008)...20 BioSpecifics,Technol...aceutical company,developing first in class colla...ecifics, President, Thomas Wegman, will present at...re Conference on Tuesday, December 2, 2008, at,4:...NY. , A live webcast of the presentation ca...
(Date:11/20/2008)... Nov. 20 Par Pharmaceuti... that the U.S. District Court for the District of ...uticals, motion for a temporary restraining order ...spules(R) (budesonide inhaled solution). In conju...eneca agreed and that it too would halt all sales ...
Breaking Biology Technology:Cyntellect Appoints Former BD Biosciences Executive Andre Lubarsky as Director of Sales - North America 2Intellect Neurosciences, Inc. Issues Letter to Shareholders From Its Chairman and CEO 2Intellect Neurosciences, Inc. Issues Letter to Shareholders From Its Chairman and CEO 3Intellect Neurosciences, Inc. Issues Letter to Shareholders From Its Chairman and CEO 4Intellect Neurosciences, Inc. Issues Letter to Shareholders From Its Chairman and CEO 5Par Pharmaceutical Halts Shipment of Budesonide Inhalation Suspension 2
...ike moms everywhere, once told me that if you coul... But where,s the fun in that? , ,Occasionally some...ed. I,m talking, of course, about the latest adver...m vents working overtime is the line, "We doubled ...s in a single pass." Oh my. What kind of business ...
... Communications Commission is discussing how to re...cy works and how it regulates communications, said...ate of Marquette University. , ,Abernathy spoke to...Annual Midwestern Telecommunications & Technology ...dband is king, a world where multiple competitors ...
... to overreact when an unwelcome amendment is attac...Legislature. More often than not, the bill is clea...ly and the Senate. Occasionally, however, a real c... week when the Assembly approved a bill to grant r...g Wisconsin companies, but to deny those credits t...
...ion Computer Systems unit of Milwaukee-based Fise...to offer a product that verifies customers, identi... ,InsightID provides access to billions of public ...ovider of banking technology, and InsightAmerica, ...liance to help prevent fraud losses from identity ...
Other Biology Technology:Double your productivity! Hype that damages technologists' reputations 2Double your productivity! Hype that damages technologists' reputations 3FCC may restructure to tackle broadband regulation 2Attempt to exclude stem cell companies from tax credit bill hurts Wisconsin 2Attempt to exclude stem cell companies from tax credit bill hurts Wisconsin 3
Rabbit polyclonal to SMARCA2 / BRM - ChIP Grade ( Abpromise for all tested applications). entrezGeneID: 6595 SwissProtID: P51531
Mouse monoclonal [CAT-2] to Chloramphenicol Acetyltransferase
...unit with motorized heated lid and skirted inner l...ys and chips. The four screw-down points allow att...orce of the motorized lid is set with software and...This interchangeable Moto Alpha unit functions on ...
...riers to suit the widest possible range of sample ...Labware carriers can be placed at any position on ...anks to a numbered grid system that ensures carrie... easy removal of the carriers without invading the...
Biology Products: