Navigation Links
Research suggests beta agonists may alter the immune system

New research at Wake Forest University School of Medicine suggests that certain inhaled asthma medications ?as well as similar chemicals our bodies produce during times of high stress ?may worsen diseases such as asthma, heart failure and lupus that involve inflammation.

The scientific team led by Raymond Penn, Ph.D., and Matthew Loza, Ph.D, found that beta-agonists, such as those used in the treatment of asthma, increase the accumulation of type 2 T cells, a type of white blood cell that participates in immune system defense mechanisms. In certain diseases such as asthma and lupus, an over-reactive type 2 T cell response occurs and is believed to contribute to the disease.

"Inhaled beta-agonists are very effective in opening up airways and allowing asthmatics to breathe, but their ability to address the underlying inflammation that causes most asthma has been debated for years," said Penn, an associate professor in the Department of Internal Medicine and the Center for Human Genomics.

The research is reported on-line in the Journal of Allergy and Clinical Immunology and will be published in an upcoming print issue.

In fact, numerous clinical studies have reported that asthma symptoms tend to worsen over time in patients on continuous beta-agonist therapy. Although the reasons for this deterioration of asthma control are not clear, the Food and Drug Administration now recommends that the treatment of asthma with long-acting beta-agonists be supplemented with inhaled anti-inflammatory medications.

Using blood samples from human participants, the scientists measured the effect of beta-agonists on white blood cells that were grown in the laboratory. They were surprised to find that the drugs promoted a preferential accumulation of type 2 T cells.

Beta-agonists belong to a class of chemicals that include the hormone adrenaline produced by the body. Consequently, conditions that elevate blood adrenaline, such as emotion
'"/>

Source:Wake Forest University Baptist Medical Center


Page: 1 2

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Quantum Dots Research Leads to New Knowledge about Protein Binding in Plants
3. Researchers find how protein allows insects to detect and respond to pheromones
4. Researchers Uncover Key Step In Manufacture of Memory Protein
5. Research advances quest for HIV-1 vaccine
6. Research on Worms Yields Clues on Aging
7. Researchers reveal the infectious impact of salmon farms on wild salmon
8. Researchers identify target for cancer drugs
9. Weill Cornell Research Reveals Secrets Of Trafficking Within Cells
10. Researchers discover molecule that causes secondary stroke
11. Researchers find missing genes of ancient organism
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Research suggests beta agonists may alter the immune system

(Date:8/21/2014)... in near darkness use a previously unknown process for ... team led by a Penn State University scientist has ... aimed at improving plant growth, harvesting energy from the ... on Lake Erie and other lakes worldwide. A paper ... Science Express edition of the journal Science ...
(Date:8/21/2014)... fungus linked to dandruff, eczema and other itchy, flaky ... further global reachesincluding Hawaiian coral reefs and the extreme ... A review in the scientific journal PLOS Pathogens ... fungi of the genus Malassezia in light ... from around the world. , University of Hawai,i at ...
(Date:8/21/2014)... food intake, health and quality of life of older ... at the University of Waterloo receiving close to $1.5 ... Research (CIHR). , Professor Heather Keller, of the ... Schlegel research chair in nutrition and aging, will receive ... living in long-term care homes are poorly nourished. The ...
Breaking Biology News(10 mins):Hot-spring bacteria reveal ability to use far-red light for photosynthesis 2Hot-spring bacteria reveal ability to use far-red light for photosynthesis 3From dandruff to deep sea vents, an ecologically hyper-diverse fungus 2Grants will fund landmark aging research at Waterloo 2
... Gulf War Illness (GWI)the chronic health condition that affects about ... to be the result of several factors, which differed in ... war, according to a Baylor University study. , ... , the study investigated links between GWI and veterans, locations ...
... person or set of identical twins. That makes them ... to international travel. But what happens when the tips ... ridges? It,s not the premise for a ... adermatoglyphia. It,s also known as "Immigration Delay Disease," because ...
... milk, a secretion from the crops of parent birds, is ... in flamingos and male emperor penguins. Essential for the growth ... produced by both parents from fluid-filled cells lining the crop ... BioMed Central,s open access journal BMC Genomics uses new technology ...
Cached Biology News:Causes of Gulf War Illness are complex and vary by deployment area -- Baylor University study 2Causes of Gulf War Illness are complex and vary by deployment area -- Baylor University study 3Shake hands with the invisible man 2Milking the pigeon: extracting the mechanisms involved 2
(Date:8/22/2014)... Texas (PRWEB) August 22, 2014 The ... and in-depth study on the current state of the ... report provides a basic overview of the industry, including ... and Chinese domestic market analysis are provided with a ... the market. A comparison between the international and Chinese ...
(Date:8/22/2014)... The identification of protein-coding variants ... accelerated by exome sequencing. Built on Roche NimbleGen’s ... SeqCap EZ Developer system has been a proven ... additionally present how he achieved coverage statistics similar ... mouse exome kits. With over 236,000 SNPs and ...
(Date:8/21/2014)... scientists has observed tiny quantum vortices in cold droplets ... Science that the exotic vortices arrange themselves ... the first time that the quantum vortices, which have ... known as superfluid helium, have been detected in nanodroplets. ... Vilesov of the University of Southern California, one of ...
(Date:8/21/2014)... August 21, 2014 The College of ... private college in the Mid-Hudson Region to be designated ... begin accepting applications from qualified “high-technology” businesses that align ... very pleased to have been selected for the START-UP ... transformative initiative to stimulate economic development in New York ...
Breaking Biology Technology:Diabetes Drugs Industry Growth Analysis in Global, China Regions Research Report Available at DeepResearchReports.com 2Diabetes Drugs Industry Growth Analysis in Global, China Regions Research Report Available at DeepResearchReports.com 3Efficient Identification of Protein-Coding Variants in a Model Organism Through Exome Sequencing, New Webinar Hosted by Xtalks 2Scientists observe quantum vortices in cold helium droplets 2The College of New Rochelle Becomes First Private College in Mid-Hudson Region to Earn START-UP NY Designation 2The College of New Rochelle Becomes First Private College in Mid-Hudson Region to Earn START-UP NY Designation 3
... Ability to Elicit Long-Lasting Tumor Protection In Vivo; Lead ... ... Cancer and/or HIV -, SAN DIEGO, CA, Sept. 24 ... vivo results of its lead therapeutic vaccine candidate for the ...
... availability of ... bone fracture screening, TORONTO, ... in health and wellness solutions, announced,they are developing components for ... assessment. In conjunction with top researchers at Toronto,s University ...
... BIRMINGHAM, Ala., Sept. 24 BioCryst,Pharmaceuticals, Inc. (Nasdaq: ... at the,UBS 2007 Global Life Sciences Conference in ... for Tuesday, September 25, 2007 at 2:00 p.m. ... http://www.biocryst.com . The,presentation will be archived for ...
Cached Biology Technology:Nventa announces publication of HspE7 data 2Nventa announces publication of HspE7 data 3Nventa announces publication of HspE7 data 4Nventa announces publication of HspE7 data 5Cooler Solutions and Leading Research Hospital to Design Revolutionary Osteoporosis Diagnosis Device 2BioCryst to Present at UBS 2007 Global Life Sciences Conference 2BioCryst to Present at UBS 2007 Global Life Sciences Conference 3
...
... Conjugated peptides or recombinant proteins are ... produce antibodies in 2 rabbits. pre-immune and ... test until the titer reaches 1:4,000 Western ... Protein G purification Antibodies are eluted using ...
Immunogen: Synthetic peptide (aa sequence is considered to be commercially sensitive) Storage: -20 C, Avoid Freeze/Thaw Cycles...
...
Biology Products: