Navigation Links
Research on Worms Yields Clues on Aging

r environment. Ethosuximide and trimethadione did, however, significantly delay age-related declines in neuro-muscular activity. Treated worms continued to display the youthful traits of fast body movement and fast pumping of mouthparts during the latter phase of their extended lives. Further tests showed that the anticonvulsants stimulated transmission of signals in nerves that control body movement. Scientists previously had found genetic mutations in C. elegans that affect both the nervous system and life span. The researchers used these mutant worms to further pin down the mechanism by which the anticonvulsants increased longevity. The worms' mutated genes affect the function of sensory neurons that regulate the release of an insulin-like hormone. "Sensory inputs from the outside regulate the level of insulin signaling inside the body, which then in turn regulates longevity in the worms," Kornfeld says. Testing the anticonvulsants on longer-lived mutant worms, the researchers found the drugs further extended their lives, although not to the same degree they extended the lives of worms with no mutations. That indicates the anticonvulsants may affect aging partly through their influence on the neural system involved in the insulin signaling pathway and partly through an independent mechanism, according to Kornfeld. "Our experiments show there is an important connection between neural function and longevity," Kornfeld says. "We're continuing this line of research to identify the precise functions of the nervous system that cause the worms to live longer." Because the researchers found that anticonvulsants affect the nervous system of C. elegans, they also plan to use the worms as model organisms to investigate how the drugs inhibit seizures in epileptic patients, a mechanism that currently is not well understood. Such research could lead to more effective treatments for epilepsy.
'"/>

Source:Washington University in St.Louis


Page: 1 2

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Quantum Dots Research Leads to New Knowledge about Protein Binding in Plants
3. Researchers find how protein allows insects to detect and respond to pheromones
4. Researchers Uncover Key Step In Manufacture of Memory Protein
5. Research advances quest for HIV-1 vaccine
6. Researchers reveal the infectious impact of salmon farms on wild salmon
7. Researchers identify target for cancer drugs
8. Weill Cornell Research Reveals Secrets Of Trafficking Within Cells
9. Researchers discover molecule that causes secondary stroke
10. Researchers find missing genes of ancient organism
11. Researchers trace evolution to relatively simple genetic changes
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Research Worms Yields Clues Aging

(Date:7/11/2014)... Using spider toxins to study the proteins that let ... say they have stumbled upon a biological tactic that ... insect plagues in a safe and environmentally responsible way. ... be lethal for one species and harmless for a ... target specific pests without harming beneficial species like bees. ...
(Date:7/10/2014)... 30, 2014  Aware, Inc. (NASDAQ: AWRE ... previously announced on June 26, 2014 that its Board ... $1.75 per share, or approximately $40 million in total.  ... 2014 and a payment date of July 24, 2014.  ... had set an ex-dividend date for this special cash ...
(Date:7/10/2014)... DALLAS , July 3, 2014 ... Sensors Market by Type (Swipe And Area), Material (Optical ... Defense, Healthcare, Commercial Security and Banking & Finance), and ... 2020", published by MarketsandMarkets, the global Fingerprint Sensors Market ... at a high CAGR of 16.8% from 2014 to ...
Breaking Biology News(10 mins):Potent spider toxin 'electrocutes' German, not American, cockroaches 2Potent spider toxin 'electrocutes' German, not American, cockroaches 3NASDAQ Sets Ex-Dividend Date for Aware, Inc.'s Special Cash Dividend of $1.75 Per Share 2Fingerprint Sensors Market worth $14.35 Billion by 2020 2Fingerprint Sensors Market worth $14.35 Billion by 2020 3
... The National Science Foundation (NSF) is funding a ... 24 high-achieving science and math undergraduates for teaching careers. ... Program within the College of Arts and Sciences at ... mathematics majors to become high school math and science ...
... protein found in the virulent avian influenza virus strain called ... of double-stranded RNA formed during viral infection, which otherwise would ... College of Medicine researchers in an online report in the ... the protein NS1 combine to form tiny tubules where double-stranded ...
... have identified a potential new therapeutic target that could ... arthritis. The study, published online ahead of ... Immunity . Specifically, the study reveals that two molecular ... and that manipulating a protein called RBP-J involved in ...
Cached Biology News:NSF grant to launch undergrads from Case Western Reserve into math and science teaching 2NSF grant to launch undergrads from Case Western Reserve into math and science teaching 3Protein 'tubules' free avian flu virus from immune recognition 2New therapeutic target identified for rheumatoid arthritis 2
(Date:7/10/2014)... CA (PRWEB) July 10, 2014 Robert Harman, ... Veterinary Medicine company, is proud to announce the relaunch of ... launching with a new series called “ What are Stem ... give an honest and straightforward foundation in the basics of ... educated decision on the right type of treatment when considering ...
(Date:7/10/2014)... July 10, 2014 EvoDerma ’s NOOME ... This rejuvenating device now comes with a second treatment cup ... time. , The new cup is thinner on the edges ... to target rough, thin and uneven surfaces on the face, ... for a stimulating treatment on areas such as the cheeks ...
(Date:7/10/2014)... , July 10, 2014  Franciscan ... use of capnography for respiratory monitoring outside ... of healthcare leaders in embracing state-of-the-art patient ... effectively patients are breathing and can alert ... By measuring the amount of carbon dioxide ...
(Date:7/10/2014)... , July 10, 2014  Kainos Capital, a ... brands, today announced that it has acquired the Slim-Fast ... in the business. Terms of the transaction were not ... and meal replacement business that markets ready-to-drink shakes, powders, ... North America and in the ...
Breaking Biology Technology:Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 2Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 3Introducing a New Bonus Treatment Cup for EvoDerma’s NOOME Anti-Aging Motion 2Franciscan St. Anthony Health-Crown Point Underscores Patient Safety Commitment Through Expanded Use of Capnography 2Kainos Capital Acquires Slim-Fast From Unilever 2
... NHS Northamptonshire,s Chief Executive, John Parkes , will ... after being offered a Visiting Professorship at The University of ... delighted to have been offered the role and I look ... there. "NHS Northamptonshire already has excellent links with ...
... NEW YORK and MUNICH, September 13, 2011 ... Unresectable Neuroendocrine Tumors in the Liver   ... that updated results from the metastatic neuroendocrine tumor (mNET) ... trial were presented at the Cardiovascular and Interventional ...
... Mich.---A new $13-million National Science Foundation center based ... materials that manipulate light in new ways. The ... nanoscale lasers, high-efficiency lighting, and quantum computers. ... C-PHOM, involves engineering and physics researchers from the ...
Cached Biology Technology:NHS Northamptonshire Chief Executive John Parkes Accepts Visiting Professorship 2Positive Phase 2 Trial Results from Neuroendocrine Tumor Cohort Presented at CIRSE 2Positive Phase 2 Trial Results from Neuroendocrine Tumor Cohort Presented at CIRSE 3Positive Phase 2 Trial Results from Neuroendocrine Tumor Cohort Presented at CIRSE 4Positive Phase 2 Trial Results from Neuroendocrine Tumor Cohort Presented at CIRSE 5$13-million NSF center to explore new ways to manipulate light at the nanoscale 2
...
...
...
... Easy Clean spin filters allow for the ... Simply place your DNA gel slice in the ... majority of your DNA is recovered. There is ... special buffers. Spin filters can also be ...
Biology Products: