Navigation Links
Research on Worms Yields Clues on Aging

Humanity has been looking for a "Fontaine de Jouvence" forever; a way to slow or stop aging. While its still nowhere to be found, we are making progress; in worms. Researchers found that an epilepsy drug used in humans had the unexpected effect of prolonging the life span of C. Elegans: A class of anti-seizure medications slows the rate of aging in roundworms, according to researchers at Washington University School of Medicine in St. Louis. When exposed to drugs used to treat epilepsy in humans, worms lived longer and retained youthful functions longer than normal. Because the drugs affect nerve signals, the researchers' observations suggest that the nervous system influences aging processes. The findings are reported in the January 14 issue of the journal Science.

The anti-aging effect was revealed in a random screening of 19 drugs approved for treating a variety of disorders in humans. "We didn't start with a hypothesis about what causes aging," says senior author Kerry Kornfeld, M.D., Ph.D., associate professor of molecular biology and pharmacology. "We wanted to look in an unbiased way at available compounds to see if any of them happened to have anti-aging activity." The researchers grew the roundworm C. elegans in the presence of the 19 drugs and found that an anticonvulsant, ethosuximide, extended the worms' lives from an average of 17 days to an average of 20 days. Further tests on anticonvulsants revealed that they also increased life span, with the drug trimethadione having the largest effect and extending the worms' lives by 47 percent. The group then sought to uncover the underlying mechanism for the effect of the anticonvulsants. It was apparent that the drugs did not mimic the anti-aging effects of caloric restriction, because the worms had abundant food and looked well-fed. The researchers also demonstrated that anticonvulsants did not extend life by protecting the worms from pathogenic bacteria in thei r environment. Ethosuximide and trimethadione did, however, significantly delay age-related declines in neuro-muscular activity. Treated worms continued to display the youthful traits of fast body movement and fast pumping of mouthparts during the latter phase of their extended lives. Further tests showed that the anticonvulsants stimulated transmission of signals in nerves that control body movement. Scientists previously had found genetic mutations in C. elegans that affect both the nervous system and life span. The researchers used these mutant worms to further pin down the mechanism by which the anticonvulsants increased longevity. The worms' mutated genes affect the function of sensory neurons that regulate the release of an insulin-like hormone. "Sensory inputs from the outside regulate the level of insulin signaling inside the body, which then in turn regulates longevity in the worms," Kornfeld says. Testing the anticonvulsants on longer-lived mutant worms, the researchers found the drugs further extended their lives, although not to the same degree they extended the lives of worms with no mutations. That indicates the anticonvulsants may affect aging partly through their influence on the neural system involved in the insulin signaling pathway and partly through an independent mechanism, according to Kornfeld. "Our experiments show there is an important connection between neural function and longevity," Kornfeld says. "We're continuing this line of research to identify the precise functions of the nervous system that cause the worms to live longer." Because the researchers found that anticonvulsants affect the nervous system of C. elegans, they also plan to use the worms as model organisms to investigate how the drugs inhibit seizures in epileptic patients, a mechanism that currently is not well understood. Such research could lead to more effective treatments for epilepsy.
'"/>

Source:Washington University in St.Louis


Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Quantum Dots Research Leads to New Knowledge about Protein Binding in Plants
3. Researchers find how protein allows insects to detect and respond to pheromones
4. Researchers Uncover Key Step In Manufacture of Memory Protein
5. Research advances quest for HIV-1 vaccine
6. Researchers reveal the infectious impact of salmon farms on wild salmon
7. Researchers identify target for cancer drugs
8. Weill Cornell Research Reveals Secrets Of Trafficking Within Cells
9. Researchers discover molecule that causes secondary stroke
10. Researchers find missing genes of ancient organism
11. Researchers trace evolution to relatively simple genetic changes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/30/2017)... Va. , June 30, 2017 ... leading developer and supplier of face and eye ... ATA Featured Product provider program. ... an innovative way to monitor a driver,s attentiveness ... greatly from being able to detect fatigue and ...
(Date:5/23/2017)... 2017  Hunova, the first robotic gym for the rehabilitation and functional ... in Genoa, Italy . The first 30 robots will ... USA . The technology was developed and patented at ... IIT spin-off Movendo Technology thanks to a 10 million euro investment from ... click: ...
(Date:5/6/2017)... May 5, 2017 RAM Group ... a new breakthrough in biometric authentication based on ... mechanical properties to perform biometric authentication. These new sensors ... material created by Ram Group and its partners. This ... transportation, supply chains and security. Ram Group is ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... October 10, 2017 , ... For the ... won a US2020 STEM Mentoring Award. Representatives of the FirstHand program travelled to ... Experience from US2020. , US2020’s mission is to change the trajectory of STEM ...
(Date:10/10/2017)... ... October 10, 2017 , ... USDM ... firm for the life sciences and healthcare industries, announces a presentation by Subbu ... , The presentation, “Automating GxP Validation for Agile Cloud Platforms,” will present a ...
(Date:10/9/2017)... ... 09, 2017 , ... At its national board meeting in North Carolina, ... University’s Departments of Physics and Astronomy, has been selected for membership in ARCS ... for the 2015 Breakthrough Prize in Fundamental physics for the discovery of the accelerating ...
(Date:10/7/2017)... ... October 06, 2017 , ... ... technologies, launched its ProxiMeta™ Hi-C metagenome deconvolution product, featuring the first commercially ... cloud-based bioinformatics software to perform Hi-C metagenome deconvolution using their own facilities, ...
Breaking Biology Technology: