Navigation Links
Research on Worms Yields Clues on Aging

Humanity has been looking for a "Fontaine de Jouvence" forever; a way to slow or stop aging. While its still nowhere to be found, we are making progress; in worms. Researchers found that an epilepsy drug used in humans had the unexpected effect of prolonging the life span of C. Elegans: A class of anti-seizure medications slows the rate of aging in roundworms, according to researchers at Washington University School of Medicine in St. Louis. When exposed to drugs used to treat epilepsy in humans, worms lived longer and retained youthful functions longer than normal. Because the drugs affect nerve signals, the researchers' observations suggest that the nervous system influences aging processes. The findings are reported in the January 14 issue of the journal Science.

The anti-aging effect was revealed in a random screening of 19 drugs approved for treating a variety of disorders in humans. "We didn't start with a hypothesis about what causes aging," says senior author Kerry Kornfeld, M.D., Ph.D., associate professor of molecular biology and pharmacology. "We wanted to look in an unbiased way at available compounds to see if any of them happened to have anti-aging activity." The researchers grew the roundworm C. elegans in the presence of the 19 drugs and found that an anticonvulsant, ethosuximide, extended the worms' lives from an average of 17 days to an average of 20 days. Further tests on anticonvulsants revealed that they also increased life span, with the drug trimethadione having the largest effect and extending the worms' lives by 47 percent. The group then sought to uncover the underlying mechanism for the effect of the anticonvulsants. It was apparent that the drugs did not mimic the anti-aging effects of caloric restriction, because the worms had abundant food and looked well-fed. The researchers also demonstrated that anticonvulsants did not extend life by protecting the worms from pathogenic bacteria in thei r environment. Ethosuximide and trimethadione did, however, significantly delay age-related declines in neuro-muscular activity. Treated worms continued to display the youthful traits of fast body movement and fast pumping of mouthparts during the latter phase of their extended lives. Further tests showed that the anticonvulsants stimulated transmission of signals in nerves that control body movement. Scientists previously had found genetic mutations in C. elegans that affect both the nervous system and life span. The researchers used these mutant worms to further pin down the mechanism by which the anticonvulsants increased longevity. The worms' mutated genes affect the function of sensory neurons that regulate the release of an insulin-like hormone. "Sensory inputs from the outside regulate the level of insulin signaling inside the body, which then in turn regulates longevity in the worms," Kornfeld says. Testing the anticonvulsants on longer-lived mutant worms, the researchers found the drugs further extended their lives, although not to the same degree they extended the lives of worms with no mutations. That indicates the anticonvulsants may affect aging partly through their influence on the neural system involved in the insulin signaling pathway and partly through an independent mechanism, according to Kornfeld. "Our experiments show there is an important connection between neural function and longevity," Kornfeld says. "We're continuing this line of research to identify the precise functions of the nervous system that cause the worms to live longer." Because the researchers found that anticonvulsants affect the nervous system of C. elegans, they also plan to use the worms as model organisms to investigate how the drugs inhibit seizures in epileptic patients, a mechanism that currently is not well understood. Such research could lead to more effective treatments for epilepsy.

Source:Washington University in St.Louis

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Quantum Dots Research Leads to New Knowledge about Protein Binding in Plants
3. Researchers find how protein allows insects to detect and respond to pheromones
4. Researchers Uncover Key Step In Manufacture of Memory Protein
5. Research advances quest for HIV-1 vaccine
6. Researchers reveal the infectious impact of salmon farms on wild salmon
7. Researchers identify target for cancer drugs
8. Weill Cornell Research Reveals Secrets Of Trafficking Within Cells
9. Researchers discover molecule that causes secondary stroke
10. Researchers find missing genes of ancient organism
11. Researchers trace evolution to relatively simple genetic changes

Post Your Comments:

(Date:11/18/2015)... York , November 18, 2015 ... Research has published a new market report titled  Gesture ... Trends, and Forecast, 2015 - 2021. According to the report, ... 2014 and is anticipated to reach US$29.1 bn by ... 2021. North America dominated ...
(Date:11/17/2015)... , November 17, 2015 ... au 19 novembre  2015.  --> Paris ... --> DERMALOG, le leader de l,innovation biométrique, ... la fois passeports et empreintes sur la même surface ... les passeports et l,autre pour les empreintes digitales. Désormais, ...
(Date:11/17/2015)... SOUTH EASTON, Mass. , Nov. 17, 2015 /PRNewswire/ ... "Company"), a leader in the development and sale of ... to the worldwide life sciences industry, today announced it ... closing of its $5 million Private Placement (the "Offering"), ... Offering to $4,025,000.  One or more additional closings are ...
Breaking Biology News(10 mins):
(Date:11/27/2015)... November 27, 2015 ... popularity of companion diagnostics is one of ... market with pharmaceutical companies and diagnostic manufacturers ... tests. . --> ... report on global cancer biomarkers market spread ...
(Date:11/25/2015)... -- PharmAthene, Inc. (NYSE MKT: PIP) announced  today that its ... (Rights Plan) in an effort to preserve the value ... 382 of the Internal Revenue Code (Code). ... its NOLs could be substantially limited if the Company ... of the Code. In general, an ownership change occurs ...
(Date:11/25/2015)... Nov. 25, 2015  Neurocrine Biosciences, Inc. (Nasdaq: ... President and CEO of Neurocrine Biosciences, will be presenting ... New York . ... website approximately 5 minutes prior to the presentation to ... the presentation will be available on the website approximately ...
(Date:11/25/2015)... PORTLAND, Oregon , November 25, 2015 /PRNewswire/ ... Deep Market Research Report is a professional and ... Genomics industry.      (Logo: ... basic overview of the industry including definitions, classifications, ... analysis is provided for the international markets including ...
Breaking Biology Technology: