Navigation Links
Research links protein to breast-cancer migration

Scientists have moved a step closer to understanding how breast cancer spreads to other parts of the body, thanks to research published this week.

The University of Manchester team has discovered a protein potentially involved in the spread or "metastatic progression" of tumors.

The researchers believe their findings could lead to new approaches to treating breast cancer as blocking the protein's actions has the potential to stop cancerous cells migrating.

"What we have identified is a new role for a protein called LPP," explained Professor Andrew Sharrocks, who headed the research team.

"Until now, this protein was only thought to function at the cell periphery but we have shown that it works in conjunction with another protein ?PEA3 ?in the cell nucleus.

"PEA3 has already been implicated in the spread of breast cancer but we have found that the LPP molecule is essential for the correct function of PEA3."

"If we can target the LPP protein and stop it from working in cancerous cells, we have a possible new route to therapy."

The research, published in the scientific journal Molecular and Cellular Biology, may have implications for other cancer systems.

"Benign tumours remain in one part of the body and are relatively easy to treat through surgery," said Professor Sharrocks, who is based in the University's Faculty of Life Sciences.

"But metastases ?malignant cancers that spread to other parts of the body ?can be much more problematic.

"Our research is potentially fundamental to all types of cancers and has the potential to offer alternative therapies to stop cancers spreading to other organs in the body."

News of the scientific breakthrough comes as the University announced Breast Cancer Campaign funding for two other research projects worth nearly £300,000.

Dr. Andrew Gilmore, also in the Faculty of Life Sciences, has been awarded a grant of £146,000 to examine in more de
'"/>

Source:University of Manchester


Page: 1 2

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Quantum Dots Research Leads to New Knowledge about Protein Binding in Plants
3. Researchers find how protein allows insects to detect and respond to pheromones
4. Researchers Uncover Key Step In Manufacture of Memory Protein
5. Research advances quest for HIV-1 vaccine
6. Research on Worms Yields Clues on Aging
7. Researchers reveal the infectious impact of salmon farms on wild salmon
8. Researchers identify target for cancer drugs
9. Weill Cornell Research Reveals Secrets Of Trafficking Within Cells
10. Researchers discover molecule that causes secondary stroke
11. Researchers find missing genes of ancient organism
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Research links protein breast cancer migration

(Date:4/10/2015)... Research and Markets ( http://www.researchandmarkets.com/research/cjk4gb/security ) has ... - NEC" report to their offering. ... to supply a range of IT security management and ... on the development of a Big Data and cloud ... Asia-Pacific region is a core ...
(Date:4/6/2015)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... on the growing mobile commerce market, announced today ... MINIATURE, MULTI-PURPOSE ANTENNA METHOD AND SYSTEM FOR ... introduces a new revolutionary method and system to ... of miniature antenna modules for multiple purposes including ...
(Date:4/2/2015)... GOTHENBURG, Sweden , April 2, 2015 ... revenues for Q1 2015 attributed to somewhat higher than ... company in the year-end report 2014 that revenues for ... MSEK that the company reported for Q4 2014. The ... continue to be negative. The complete interim report will ...
Breaking Biology News(10 mins):NEC Security Competitive Profile 2015 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 3NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 4Fingerprint Cards Revises Revenues for Q1 2015 2
... (NorthShore) and Northwestern University have discovered that fiber optic ... blood levels in the colonic lining (mucosa) in humans, ... cancer. The study appears in the October ... of the American Gastroenterological Association (AGA) Institute. ...
... 1, 2008 The last decade has seen a ... a mounting public health crisis across the world. ... physicians and patients a potential new approach toward the ... "As bacteria become more resistant to our current classes ...
... rivers comes from erosion of the landscape as well as ... much each source contributes to a river and how ... is the subject of research by Peter Whiting, professor of ... of certain radionuclides found in the soil, including beryllium and ...
Cached Biology News:Breakthrough optical technology to assess colon cancer risk, accuracy 2Breakthrough optical technology to assess colon cancer risk, accuracy 3Groundbreaking discovery may lead to stronger antibiotics 2Case Western Reserve University project ties soil conservation and river management together 2
(Date:5/5/2015)... Calif. , May 5, 2015  23andMe, Inc., ... of the Lupus Research Study in collaboration ... individuals with systemic lupus erythematosus, more commonly known as ... genetics of lupus. The effort is also in collaboration ... Lupus Awareness Month in May. Approximately 1.5 ...
(Date:5/5/2015)... Israel , May 5, 2015  Tikcro ... Company was approved to continue trading on OTCQB  ... OTCQB Marketplace allows for a continuous ... broker-dealers. Investors can have real-time quotes and market ... The OTCQB Marketplace includes U.S. and ...
(Date:5/5/2015)... 5, 2015  A group of biotechnology executives and ... Research Institute, a non-profit organization dedicated to providing education, ... from disorders of consciousness.  ... ... which no voluntary actions can be initiated by the ...
(Date:5/5/2015)... 2015 CytomX, a biotechnology company developing Probody™ ... Sean McCarthy , D. Phil., chief executive officer, ... New York at 1:15 p.m. ... an overview of CytomX,s Probody pipeline, including the company,s ... About CytomX Therapeutics CytomX Therapeutics develops Probody™ ...
Breaking Biology Technology:23andMe Launches the Lupus Research Study in Collaboration with Pfizer Inc. 223andMe Launches the Lupus Research Study in Collaboration with Pfizer Inc. 3Tikcro Technologies Announces Approval to Continue Trading on OTCQB 2Biotechnology Executives and Medical Doctors Team Up to Tackle Coma and Disorders of Consciousness 2Biotechnology Executives and Medical Doctors Team Up to Tackle Coma and Disorders of Consciousness 3Biotechnology Executives and Medical Doctors Team Up to Tackle Coma and Disorders of Consciousness 4Biotechnology Executives and Medical Doctors Team Up to Tackle Coma and Disorders of Consciousness 5
... attempt to measurably increase the amount of capital available ... Institutions and the Department of Commerce , ... , ,Lorrie Keating Heinemann, secretary of DPI, said the ... percentage of their funds and perhaps become limited partners ...
... - Mirus Bio Corp. , a Madison-based company engaged ... granted a United States patent on a new injection delivery method. ... an effective method to deliver nucleic acids such as RNA for ... University of Wisconsin-Madison , it has developed a more rapid ...
... - In an effort to spur entrepreneurship in a ... Foundation has named the University of Wisconsin-Madison ... the university has received $5 million to help train ... campus initiative in 2004 to bring entrepreneurship education to ...
Cached Biology Technology:State agencies propose venture capital center 2Mirus Bio awarded patent on RNA delivery 2Mirus Bio awarded patent on RNA delivery 3UW gets $5M to extend entrepreneurship 2
Mouse monoclonal antibody raised against a partial recombinant DHX8. NCBI Entrez Gene ID = DHX8...
... of the members of the GPCR family ... splicing--which has important implications for drug research. ... classical expression profiling and at the same ... of the gene that are expressed in ...
... 5.6" TFT color screen, without Camera ... camera with 8.0 mega pixel resolution. It is ... budget. View image from large 5.6" TFT color ... is suitable to capture image for fluorescent gels, ...
... The binding specificity and signaling of ... known to be modified by alternative splicing--which ... GPCR SpliceArrays you can perform a classical ... detect the different alternatively spliced forms of ...
Biology Products: