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Research into how prions act in the brain could hold the key to defeating diseases

Scientists at the University of Southampton are continuing their pioneering research into diseases such as Creutzfeld-Jakob Disease (CJD) and related conditions caused by tiny particles known as prions, thanks to a £300,000 grant from the Medical Research Council.

So far, there have been 148 deaths from confirmed or probable variant CJD (vCJD) in the UK. This is the human disease thought to be caused by eating food contaminated with prions that is also responsible for the epidemic of BSE or 'mad cow disease' in cattle.

Research has already found that the highly-infectious prions are misfolded proteins that spread rapidly in the brain and are very difficult to destroy. It is not known what causes the proteins to develop in this abnormal way and it is not known how they kill nerve cells in the brain. Professor Hugh Perry and colleagues of the University's School of Biological Sciences are examining exactly what makes particular nerve cells in the brain more susceptible to attack by prions.

'We are looking ultimately at ways of early detection and diagnosis so effective treatment can begin as soon as possible,' said Professor Perry. 'There is much we do not know about prions and prion diseases but our research teams are following several lines of investigation.'

Prion diseases are extremely complex and understanding their pathways and mechanisms remains a real challenge. The illnesses are fatal and once ill, patients deteriorate rapidly. There is currently no simple and accurate way to diagnose types of prion disease such as vCJD, no effective way of managing or treating patients and no cure is yet in sight.

Estimates of the numbers of people at risk from primary exposure to meat infected products and possible risk from secondary exposure, for example through blood transfusion, are still being debated and recalculated as new research adds new knowledge and information to the overall picture.


Source:The University of Southampton

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