Navigation Links
Research holds promise for herpes vaccine

ine where the genetic instructions that make ICP0 were disrupted. Without instructions on how to do its clever ICP0 trick, the virus can still establish an infection in animals, but the spread of the virus is stopped long before disease can occur.

"In short, we can disarm the virus such that it is absolutely unable to cause disease, but is still remarkably potent as a vaccine," Halford said.

In a human vaccine, the genetic instructions for ICP0 would actually be removed, creating an "attenuated," or weakened virus. The rest of the herpes simplex virus' genetic code would remain intact. Measles, mumps, rubella, polio and yellow fever vaccines are all made from attenuated viruses.

Research in recent decades has focused on subunit vaccines, which are made from one piece of a virus (a protein subunit). Subunit vaccines are safer than attenuated virus vaccines because the subunit cannot replicate or cause disease. However, subunit vaccines have proven ineffective in protecting people against persistent infections like genital herpes and AIDS, Halford said.

"From a theoretical standpoint, subunit vaccines are poor mimics of a natural virus infection," Halford said. "There's not enough there for our immune systems to build a protective response against the actual virus."

Halford, 38, is aware that his approach is controversial.

"This is where I'm young enough that I don't know how long it can take to swing popular opinion among scientists and clinicians," he said. "I would hope that in five to six years the scientific community would be willing to seriously consider these proposals."

Halford hopes to find a commercial partner or secure government funding to advance his research toward a human vaccine.

"I'd like to take this concept from the chalkboard to the clinics," he said.


'"/>

Source:Montana State University


Page: 1 2

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Quantum Dots Research Leads to New Knowledge about Protein Binding in Plants
3. Researchers find how protein allows insects to detect and respond to pheromones
4. Researchers Uncover Key Step In Manufacture of Memory Protein
5. Research advances quest for HIV-1 vaccine
6. Research on Worms Yields Clues on Aging
7. Researchers reveal the infectious impact of salmon farms on wild salmon
8. Researchers identify target for cancer drugs
9. Weill Cornell Research Reveals Secrets Of Trafficking Within Cells
10. Researchers discover molecule that causes secondary stroke
11. Researchers find missing genes of ancient organism
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Research holds promise for herpes vaccine

(Date:12/17/2014)... Dec. 16, 2014 Research and Markets ... of the "Global Chemical Sensor Market 2015-2019" ... http://photos.prnewswire.com/prnh/20130307/600769 One major ... demand for medical sensors in biomedical applications. Chemical ... quick and correct diagnosis during surgical procedures. The ...
(Date:12/11/2014)... N.C. , Dec. 10, 2014  That blood pressure ... quite a while. Hypertension – the medical term for high ... the early 1800s, and the inflatable cuff that,s used in ... doesn,t, however, mean there,s nothing new about hypertension, its triggers ... long-held beliefs about the condition and the best ways to ...
(Date:12/10/2014)... -- CIE San Diego has launched an innovative trust ... that enhances care coordination among social service and care ... earned a second $1 million grant from the Alliance ... in community and; will be recognized as a "Live ... 4-6p. CIE San Diego today announced the ...
Breaking Biology News(10 mins):Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 3Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 4
... domain . . . With the ... National Laboratory,s Center for Nanophase Materials Sciences, scientists ... open new pathways for nanoscale electronics. The study, ... ) and led by Ramamoorthy Ramesh of Lawrence ...
... avoid creating greenhouse gases, it makes more sense using ... reserves than to plow it up for corn to ... "Converting set-asides to corn-ethanol production is an inefficient ... be encouraged until ethanol-production technologies improve," the study,s authors ...
... ongoing mission to train and educate scientists on the ... Craig Venter Institute,s (JCVI) Eukaryotic Genome Annotation and Analysis ... train 40 United States Agriculture Department (USDA) scientists at ... will focus on the use of JCVI,s eukaryotic annotation ...
Cached Biology News:Story tips from the Departments of Energy's Oak Ridge National Lab -- March 2009 2Story tips from the Departments of Energy's Oak Ridge National Lab -- March 2009 3Study critiques corn-for-ethanol's carbon footprint 2Study critiques corn-for-ethanol's carbon footprint 3JCVI program trains USDA scientists on eukaryotic genome analysis 2
(Date:12/24/2014)... (PRWEB) December 23, 2014 Nashville Fertility ... was elected treasurer for the American Society for Reproductive ... knowledge and research in reproductive medicine. In his ... seat on the executive board and will have a ... Dr. Hill has actively supported ASRM since 1984 when ...
(Date:12/24/2014)... , Dec. 23, 2014 Vermillion, Inc. ... on gynecologic disease, announced today that investors including ... Birchview Fund LLC and several Vermillion directors have ... shares of Vermillion,s common stock and warrants to ... a private placement.  Under the ...
(Date:12/24/2014)... NEW YORK , Dec. 23, 2014  NeuroLifeSciences ... of mazindol in children with attention deficit/hyperactivity disorder published ... 2014 . The paper, titled "Pilot ... deficit/hyperactivity disorder" ( Konofal et al, Drug ... 2014 ) shows that mazindol might be an ...
(Date:12/22/2014)... HILL, N.C. , Dec. 22, 2014 /PRNewswire/ ... today announced that it has signed a letter ... company that has developed and patented a nanotechnology-based ... medical diagnostics products that enable rapid on-site collection ... alcohol use/abuse and health issues in an immediate, ...
Breaking Biology Technology:Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 2Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 3Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 2Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 3Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 4Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 5Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 2Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 3ALNE Announces Intention To Acquire BioTechPharma 2
... for In-Vitro / In-Vivo ... Correlation Modeling in Drug Development, MOUNTAIN VIEW, ... a leading provider of software, strategic,consulting, and regulatory services ... MS, Director of,Training and Pre-Sales, will speak to members ...
... Insmed Inc. (Nasdaq:,INSM), a developer of follow-on ... request a hearing before The NASDAQ Listing,Qualifications Panel ... delist the Company,s common stock from The NASDAQ ... The NASDAQ Stock Market ("NASDAQ") on,June 17, 2008 ...
... 2008 / b3c newswire /  - Rentschler ... biopharmazeutischer Arzneimittel gibt die Inbetriebnahme einer 2.500 ... nun über neun unabhängige GMP-Produktionslinien mit Arbeitsvolumen ... für die Herstellung von klinischen Prüfmustern und ...
Cached Biology Technology:Pharsight to Present on IVIVC at Bioequivalence & Bioavailability Strategies Conference 2Pharsight to Present on IVIVC at Bioequivalence & Bioavailability Strategies Conference 3Insmed to Request Hearing Before NASDAQ Panel to Review NASDAQ Staff Determination 2Rentschler Biotechnologie erweitert Kapazitten fr Produktion in Sugetierzellen 2
... Assay Kits are ideal for studying or ... GR Competitor Assay Kits contain partially purified ... of the following proprietary fluorescent glucocorticoid Fluormone ... (red assay kit), or GS Far Red ...
... complete kit contains enough separation ... a total of 5 x ... includes the StemSep red magnet ... and buffers for the specific ...
... * Source rat ... T25 plated cells $550.00, * ... 120 population doublings, * This ... complete ,growth medium M55007-08 and ...
... Tissue Arrays are intended for laboratory research ... fixed in neutral buffered formalin and embedded ... was performed by certified pathologists. Tissue ... and relocated into a new recipient paraffin ...
Biology Products: