Navigation Links
Research could lead to better drugs and whiter whites

Groundbreaking research published today could revolutionise the way drugs are made and have major implications for the industrial sector, say its authors.

The University of Manchester team, working with colleagues in Bristol, has provided a unique insight into the working of enzymes ?biological molecules that speed up chemical reactions in the body.

When these chemical reactions go wrong they can lead to disease, so modern drugs are designed to target enzymes and 'switch them off'.

But their ability to accelerate chemical reactions means enzymes are also used in a number of commercial processes, including brewing, food processing, domestic cleaning and paper manufacturing.

"Improving our fundamental knowledge of how enzymes work is important to a wide range of pharmaceutical and industrial fields," said Professor Nigel Scrutton, one of the lead researchers at Manchester.

"Enzymes are central to the existence of life because most chemical reactions in our cells would take place too slowly or produce a different outcome without their involvement.

"But when enzymes malfunction they can cause serious diseases, so modern drugs are designed to prevent enzymes accelerating, or 'catalysing', inappropriate reactions.

"Our research has shown at an atomic level how enzymes act as catalysts; the findings are a radical departure from the traditional view of how they work and might explain why attempts to make artificial enzymes have so far been disappointing.

The work ?published as a major research article in the leading journal Science ?builds on earlier studies by Professor Scrutton and Manchester colleagues, Professor Michael Sutcliffe and Dr David Leys.

Together they have shown, now in unprecedented detail, how enzymes avoid unfavourable energy barriers caused by the resistance to a reaction by allowing matter to 'flow through' the barrier ?a process known as quantum mechanical tunnelling.

"We hav
'"/>

Source:University of Manchester


Page: 1 2

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Quantum Dots Research Leads to New Knowledge about Protein Binding in Plants
3. Researchers find how protein allows insects to detect and respond to pheromones
4. Researchers Uncover Key Step In Manufacture of Memory Protein
5. Research advances quest for HIV-1 vaccine
6. Research on Worms Yields Clues on Aging
7. Researchers reveal the infectious impact of salmon farms on wild salmon
8. Researchers identify target for cancer drugs
9. Weill Cornell Research Reveals Secrets Of Trafficking Within Cells
10. Researchers discover molecule that causes secondary stroke
11. Researchers find missing genes of ancient organism
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Research could lead better drugs and whiter whites

(Date:3/24/2015)... , March 24, 2015   NexID Biometrics ... with critical security-authentication needs, today announced the beginning of ... (FFD) solution. The company, based in ... at the three-day Connect:ID Expo, which began here today ... NexID said version 2.0 of its SDK boosts the ...
(Date:3/23/2015)... , March 23, 2015  In the 2014 ... fraud case conviction losses. This figure accounts for a ... according to The Nilson Report, exceeds $11 billion globally. ... tool after a crime has occurred. Investor Mark ... polygraph expert Joe Paolella partnered to administer ...
(Date:3/20/2015)... OXFORD, Conn. , March 20, 2015 ... "Company"), a biometric authentication company focused on the growing ... Wocket® smart wallet is one of the products featured ... today, March 20th at 11:00 PM EST on the ... travels to Las Vegas , site ...
Breaking Biology News(10 mins):NexID Begins Shipments Of Version 2.0 Fake-Finger-Detection Solution 2Polygraph Test Now Used to Protect Investors From Fraud 2Polygraph Test Now Used to Protect Investors From Fraud 3NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 2NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 3
... at the Oregon National Primate Research Center at Oregon ... gene that appears to control how stem cells become ... implications for the study of Parkinson's disease, brain and ... might be combated by replacing lost or damaged brain ...
... that produce bird feathers have been visualized and analyzed for ... journey that may ultimately shed light on human organ regeneration. ... the journal Nature, was performed by a group of prominent ... University of Southern California. , "What we found is that ...
... team of scientists is proposing that endangered California condors raised ... so that the birds can once again feast on the ... , The researchers from Stanford University and four other institutions ... early condors and their potential prey. Writing in the Nov. ...
Cached Biology News:OHSU discovery sheds light into how stem cells become brain cells 2USC researchers track down the stem cells that create feathers 2USC researchers track down the stem cells that create feathers 3Seal rookeries could provide a reliable food source for endangered California condors, study finds 2Seal rookeries could provide a reliable food source for endangered California condors, study finds 3Seal rookeries could provide a reliable food source for endangered California condors, study finds 4Seal rookeries could provide a reliable food source for endangered California condors, study finds 5
(Date:3/26/2015)... , March 26, 2015 ... a global clinical research organization , ... a definitive agreement to acquire all of ... ("QSI"), a leading provider of specialized pharmacovigilance ... to the collection, detection, assessment, monitoring, and ...
(Date:3/26/2015)... the popular news television program that airs in numerous markets ... actor James Earl Jones, has announced that it will address ... Botany is commonly described as the scientific study of plants, ... complicated than that. Scientists and other professionals study a wide ... bacteria known to man to the largest trees that grow ...
(Date:3/26/2015)... WriteResult, a premier provider of ePRO ... University’s School of Public Health and New Haven Farms ... 4 month-long project. The goal of the study was ... with free access to fresh produce and nutrition education ... like high blood pressure, diabetes and weight gain. Patients ...
(Date:3/25/2015)... Agnition announced today that it will ... airing for the first time at 7:30 a.m. CST ... will explore the extremely important role soil microbes perform ... patented Microbial Catalyst™ technology that enhances soil and plant ... will air again on April 28. , A biochemist ...
Breaking Biology Technology:PAREXEL Announces Execution of Definitive Agreement to Acquire Quantum Solutions India, Strengthening Leadership In Pharmacovigilance Services 2PAREXEL Announces Execution of Definitive Agreement to Acquire Quantum Solutions India, Strengthening Leadership In Pharmacovigilance Services 3PAREXEL Announces Execution of Definitive Agreement to Acquire Quantum Solutions India, Strengthening Leadership In Pharmacovigilance Services 4Yale and New Haven Farms Improving Patient Health with WriteResult's myPROpad™ 2Yale and New Haven Farms Improving Patient Health with WriteResult's myPROpad™ 3Agnition to be Featured In Upcoming Episode of American Farmer on RFD-TV 2
... Vicus Therapeutics, LLC, an,oncology-focused, clinical-stage, biopharmaceutical ... Clinical Research and Development, is,scheduled to present ... Tri-Conference on March 28st at 1:35 p.m. ... San Francisco. Dr. Rao will focus on,considerations ...
... to HistoRx AQUA(R) ... for tissue biomarker analysis-, NEW HAVEN, Conn., March ... a three-year agreement with Eli Lilly and Company,(NYSE: ... tissue biomarker,analysis widely available to Lilly researchers and clinicians ...
... company on track for Phase I/II trial ... ... Genetics Inc.,(TSX: SBS), a biotechnology company developing a portfolio of therapeutic,proteins ... toxicology study in animals to demonstrate the safety and,comparability of its ...
Cached Biology Technology:HistoRx and Lilly Extend, Expand AQUA(R) Analysis Partnership 2HistoRx and Lilly Extend, Expand AQUA(R) Analysis Partnership 3SemBioSys initiates toxicology study for safflower-produced insulin 2SemBioSys initiates toxicology study for safflower-produced insulin 3
...
... designed to allow neomycin/kanamycin selection in ... loxP-PGK-gb2-neo-loxP template encodes the neomycin/kanamycin resistance ... (gb2) for expression of kanamycin resistance ... (PGK) for expression of neomycin resistance ...
... inch long PYREX NMR tubes are made from ... valves, and vacuum racks. They are designed for ... 500MHz. They have an O.D. of 4.97 + ... These NMR tubes can be used with the ...
... TProfessional Thermocycler combines top performance with exquisite ... high speed and unparalleled temperature uniformity. The ... programming in a spreadsheet or alternatively in ... Lid opens on the push of a ...
Biology Products: