Navigation Links
Research advances quest for HIV-1 vaccine

Scientists have uncovered new information that may help guide design of vaccines for HIV-1, the virus that causes AIDS. A new detailed structural analysis of the complex formed by an anti-HIV antibody called 4E10 and its specific target provides insight into why this particular antibody is so broadly effective, a rare characteristic for HIV discovered thus far. The research is published in the February issue of Immunity.

Vaccination has been a successful strategy for protecting humans from many potentially harmful viruses. However, designing a suitable vaccine for HIV-1 has been a highly challenging and thus far unsuccessful endeavor. HIV-1 is enormously variable and it has been difficult to isolate antibodies that will recognize the many different strains of the virus. The antibody 4E10 was derived from HIV-1 infected patients by Dr. Hermann Katinger in Vienna and is the broadest acting neutralizing antibody against HIV-1 that is currently known. This antibody recognizes a protein called gp41 that is found on the surface of the virus. The gp41 protein is thought to play a key role in mediating entry of HIV-1 into human cells.

A research group led by Drs. Dennis R. Burton and Ian A. Wilson from The Scripps Research Institute in La Jolla, California performed a study examining the detailed molecular structure of the complex formed when 4E10 binds to gp41 and determining how interaction of 4E10 with gp41 influences the virus.

X-ray crystallography was used to determine the structure of the complex formed by association of 4E10 with a peptide fragment that is identical to the section of gp41 that the antibody recognizes. The researchers identified the specific amino acids on gp41 that 4E10 interacts with and the 3D structure adopted by these amino acids. These study results suggest that 4E10 interacts with gp41 at a conserved region very close to the surface of the virus and they reveal some special characteristics of 4E10 that make it unusually
'"/>

Source:Cell Press


Page: 1 2

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Quantum Dots Research Leads to New Knowledge about Protein Binding in Plants
3. Researchers find how protein allows insects to detect and respond to pheromones
4. Researchers Uncover Key Step In Manufacture of Memory Protein
5. Research on Worms Yields Clues on Aging
6. Researchers reveal the infectious impact of salmon farms on wild salmon
7. Researchers identify target for cancer drugs
8. Weill Cornell Research Reveals Secrets Of Trafficking Within Cells
9. Researchers discover molecule that causes secondary stroke
10. Researchers find missing genes of ancient organism
11. Researchers trace evolution to relatively simple genetic changes
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Research advances quest for HIV vaccine

(Date:9/1/2014)... adapted to a life without light. They emit echolocation sounds ... distance to obstacles or prey. In their brains, they have ... out by researchers at Technische Universitt Mnchen (TUM) has shown ... external factors. , Closer objects appear larger ... an object, the number of activated neurons in its brain ...
(Date:8/31/2014)... a fast and accurate tool to diagnose tuberculosis ... newly developed test (TAM-TB assay) is the first ... children. The test features excellent specificity, a similar ... of a blood test. The promising findings are ... in children, particularly in tuberculosis-endemic regions. , The ...
(Date:8/31/2014)... us, germs go after each other. But when viruses ... infected microbes: Sometimes viruses actually carry helpful genes that ... or better attack its own hosts. , Scientists have ... robotically destroy anything it recognized as invading viral genes. ... that one variety of the bacterial immune system known ...
Breaking Biology News(10 mins):Zooming in for a safe flight 2New tuberculosis blood test in children is reliable and highly specific 2Discovery reveals how bacteria distinguish harmful vs. helpful viruses 2Discovery reveals how bacteria distinguish harmful vs. helpful viruses 3
... A team of scientists led by Dr. Kuniya Abe ... one of the most comprehensive genome-wide experimental analyses of ... the April issue of the journal Genome Research. , ... generated from opposite DNA strands at the same locus. ...
... that glow in the dark, University of Houston researchers ... clock cycles. , Gregory M. Cahill, associate professor of ... fellow UH researcher who is now at the University ... titled "Light-dependent Development of Circadian Gene Expression in Transgenic ...
... approval to Mylan Technologies, Inc., for the first generic ... used to treat patients suffering from severe chronic pain ... to the skin, this patch technology delivers fentanyl, an ... body through the skin providing pain relief for up ...
Cached Biology News:Researchers rein in regulatory RNAs 2Glow-in-the-dark zebrafish at UH hold keys to biological clocks 2Glow-in-the-dark zebrafish at UH hold keys to biological clocks 3
(Date:9/1/2014)... (PRWEB) September 01, 2014 The ... $1,712.1 million by 2019 from $1,070.7 million in ... 2014 to 2019. The global oligonucleotide synthesis market ... services, applications, end users, and geography. The synthesized ... growth rate in the oligonucleotide synthesis market during ...
(Date:8/31/2014)... August 31, 2014 2014 ... is a professional and in-depth research report ... basic Polyacrylamide information, including Polyacrylamide definition, classification, ... as industry overview. This research covers the ... well as global industry analysis covering macroeconomic ...
(Date:8/29/2014)... based on electrons, but one of the most promising ... circuits based on light (photons) instead of electrons. First, ... stream of single photons and control their direction. Researchers ... to achieve this control, but now scientists at the ... stream of photons emitted one at a time and ...
(Date:8/29/2014)... VANCOUVER , Aug. 29, 2014 /PRNewswire/ - ... (OTCQX: ICOTF), today reported financial results for the ... specified otherwise, are expressed in Canadian dollars and ... Second Quarter 2014 Highlights , ... visual acuity (VA) primary endpoint for subjects enrolled ...
Breaking Biology Technology:9.8% CAGR for Oligonucleotide Synthesis Market Globally to 2019 Says a New Research Report Available at RnRMarketResearch.com 29.8% CAGR for Oligonucleotide Synthesis Market Globally to 2019 Says a New Research Report Available at RnRMarketResearch.com 39.8% CAGR for Oligonucleotide Synthesis Market Globally to 2019 Says a New Research Report Available at RnRMarketResearch.com 49.8% CAGR for Oligonucleotide Synthesis Market Globally to 2019 Says a New Research Report Available at RnRMarketResearch.com 5International Polyacrylamide Industry & Copper Iodide Market Data Analysis Now Available at DeepResearchReports.com 2International Polyacrylamide Industry & Copper Iodide Market Data Analysis Now Available at DeepResearchReports.com 3Breakthrough in light sources for new quantum technology 2iCo Therapeutics Announces Second Quarter 2014 Financial Results 2iCo Therapeutics Announces Second Quarter 2014 Financial Results 3iCo Therapeutics Announces Second Quarter 2014 Financial Results 4
... , EDMONTON, Dec. 11 /PRNewswire-FirstCall/ - ... treatment of multiple sclerosis (MS), today announced that the Company ... Award" at the 4th Annual Scrip Awards held in London, ... development agreement granting Eli Lilly and Company (Lilly) exclusive worldwide ...
... http://www.myngle.com ), the global language platform, has just ... Europe Unlimited,s European Venture Summit,(EVS) ( http://www.e-unlimited.com/events/p200245/overview.asp ). ... is a showcase for the most promising Information ... from all over Europe to meet,and present themselves ...
... Mass., Dec. 11 Pressure BioSciences, Inc. (Nasdaq: ... International ("Omni") today announced that they have entered into ... the terms of the Agreement, the companies will: (1) ... information; (2) co-promote certain products at industry trade shows ...
Cached Biology Technology:BioMS Medical recognized at Scrip Awards 2008 2Myngle Best ICT Company at the European Ventures Summit 2Pressure BioSciences, Inc. and Omni International Announce Marketing, Distribution, and Technology Development Agreement 2Pressure BioSciences, Inc. and Omni International Announce Marketing, Distribution, and Technology Development Agreement 3Pressure BioSciences, Inc. and Omni International Announce Marketing, Distribution, and Technology Development Agreement 4Pressure BioSciences, Inc. and Omni International Announce Marketing, Distribution, and Technology Development Agreement 5
High-throughput DNA preparation and end sequencing of BAC libraries. 3730xl DNA sequencers. LIMS tracking utilizing Geospiza's Finch system. Full-length BAC sequencing also available. Our expertise h...
... DNA sequencing is the experimental process ... DNA region. The automated DNA Sequencing is ... thermostable DNA polymerase, which allows cycle sequencing ... and detected in a capillary instrument controlled ...
... 192 ) The antibody is preadsorbed to remove ... antibody buffered aqueous glycerol solution A ... Mg 2+ and Ca 2+ ), pH ... BSA (IgG, protease free) and 0.05% sodium azide ...
... The Bio-Plex maintenance, calibration, ... a custom 96-well plate used ... and calibration procedures using the ... MCV plate is for use ...
Biology Products: