Navigation Links
Research advances quest for HIV-1 vaccine

Scientists have uncovered new information that may help guide design of vaccines for HIV-1, the virus that causes AIDS. A new detailed structural analysis of the complex formed by an anti-HIV antibody called 4E10 and its specific target provides insight into why this particular antibody is so broadly effective, a rare characteristic for HIV discovered thus far. The research is published in the February issue of Immunity.

Vaccination has been a successful strategy for protecting humans from many potentially harmful viruses. However, designing a suitable vaccine for HIV-1 has been a highly challenging and thus far unsuccessful endeavor. HIV-1 is enormously variable and it has been difficult to isolate antibodies that will recognize the many different strains of the virus. The antibody 4E10 was derived from HIV-1 infected patients by Dr. Hermann Katinger in Vienna and is the broadest acting neutralizing antibody against HIV-1 that is currently known. This antibody recognizes a protein called gp41 that is found on the surface of the virus. The gp41 protein is thought to play a key role in mediating entry of HIV-1 into human cells.

A research group led by Drs. Dennis R. Burton and Ian A. Wilson from The Scripps Research Institute in La Jolla, California performed a study examining the detailed molecular structure of the complex formed when 4E10 binds to gp41 and determining how interaction of 4E10 with gp41 influences the virus.

X-ray crystallography was used to determine the structure of the complex formed by association of 4E10 with a peptide fragment that is identical to the section of gp41 that the antibody recognizes. The researchers identified the specific amino acids on gp41 that 4E10 interacts with and the 3D structure adopted by these amino acids. These study results suggest that 4E10 interacts with gp41 at a conserved region very close to the surface of the virus and they reveal some special characteristics of 4E10 that make it unusually
'"/>

Source:Cell Press


Page: 1 2

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Quantum Dots Research Leads to New Knowledge about Protein Binding in Plants
3. Researchers find how protein allows insects to detect and respond to pheromones
4. Researchers Uncover Key Step In Manufacture of Memory Protein
5. Research on Worms Yields Clues on Aging
6. Researchers reveal the infectious impact of salmon farms on wild salmon
7. Researchers identify target for cancer drugs
8. Weill Cornell Research Reveals Secrets Of Trafficking Within Cells
9. Researchers discover molecule that causes secondary stroke
10. Researchers find missing genes of ancient organism
11. Researchers trace evolution to relatively simple genetic changes

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Research advances quest for HIV vaccine

(Date:11/20/2009)...mber 2009 issue of the journal GENETICS ( http:/...of genes (1-aminocyclopropane-1-carboxylate syntha...f ethylene. This gas affects many aspects of plant...tion for future genetic manipulation that could ma...hrive in difficult terrain, increase yields, and o...
(Date:11/20/2009)...r abstracts to the World Congress on Osteoporosis ...g devoted to all aspects of osteoporosis and osteo...will be held in Florence, Italy from May 5-8, 2010...online at http://www.iofwco-ecceo10.org , The...and ESCEO are pleased to announce that seven speci...
(Date:11/20/2009)...d sealcoats in parking lots may be the culprit in .... PAHs or polycyclic aromatic hydrocarbons are ...s, and can have toxic effects. It,s long been know..., the specific sources of these PAHs are largely u...or areas near parking lots with coal-tar-based sea...
Breaking Biology News(10 mins):It's a gas: New discovery may lead to heartier, high-yielding plants 2Special sessions announced for World Congress on Osteoporosis 2010 - IOF WCO - ECCEO10 2Special sessions announced for World Congress on Osteoporosis 2010 - IOF WCO - ECCEO10 3From toxic dust and algae to ill winds from Africa 2From toxic dust and algae to ill winds from Africa 3From toxic dust and algae to ill winds from Africa 4From toxic dust and algae to ill winds from Africa 5Lifetime Commitment to Public Health Recognized 54632 1Lifetime Commitment to Public Health Recognized 54632 2PharmaTelevision Launches the First Daily News Show for the Life Sciences Industry 13593 1PharmaTelevision Launches the First Daily News Show for the Life Sciences Industry 13593 2PharmaTelevision Launches the First Daily News Show for the Life Sciences Industry 13593 3PharmaTelevision Launches the First Daily News Show for the Life Sciences Industry 13593 4Leading Health Foundations Say Prevention is Vital to Health Systems Reform 54627 1Leading Health Foundations Say Prevention is Vital to Health Systems Reform 54627 2Leading Health Foundations Say Prevention is Vital to Health Systems Reform 54627 3Leading Health Foundations Say Prevention is Vital to Health Systems Reform 54627 4
...ody,s cells to correctly receive and convey signal...play a critical role in this regulation by providi... are helped in this process by protein molecules c... these domains work may open up new targets of opp...uch as cancer, diabetes and various inflammatory d...
...tists have provided new details about how cancer c...ts the blood cells needed for blood clotting. Kat...at the University of Yamanashi, Japan, and colleag...n the surface of platelets that plays a key role i...ts could help design new drugs that prevent cancer...
...hting skin wrinkles has been developed at the Hebr...ironmental Quality Sciences. , In her doctoral re... in isolating a plant-based antioxidant that delay... collagen fibers in the skin. Dr. Bossi conducted ...dar, the Karl Bach Professor of Agricultural Bioch...
Other Biology News:Chemists get grip on slippery lipids 2How cancer spreads by aggregating platelets 2How cancer spreads by aggregating platelets 3Antioxidant to retard wrinkles discovered by Hebrew University researcher 2
(Date:11/18/2009)...tandards and Technology (NIST) has demonstrated a ...g and measuring elusive hazards such as concealed ...or pesticides distributed in soil by wind and rain...entional techniques for detecting traces of these ...ving distinct electrically positive and negative e...
(Date:11/18/2009)...d postage stamp that can sniff out poisonous gases...s reported in the Sept. 13 issue of the journal N...the University of Illinois have developed an artif...strial chemicals (TICs) that is simple, fast and i...sensor array could be useful in detecting high exp...
(Date:11/18/2009)...ewswire-FirstCall/ -- Sangamo BioSciences, Inc. (N...University of Pennsylvania investigator sponsored ...ease (ZFN) based product, SB-728-T, for HIV/AIDS w... internet. ,, Data were presented in a student ... Medicine from a single subject treated with SB-72...
(Date:11/18/2009)...wire-FirstCall/ -- Masimo (Nasdaq: MASI ), the ...ugh Motion and Low-Perfusion pulse oximetry, annou...f the largest healthcare Group Purchasing Organiza...chasing agreement for "gold standard" Masimo SET &...erred contract pricing to Uni.H.A.,s 53 member hos...
Breaking Biology Technology:Prototype NIST method detects and measures elusive hazards 2Opto-electronic nose sniffs out toxic gases 2Opto-electronic nose sniffs out toxic gases 3Sangamo BioSciences Provides Update on Phase 1 Safety Trial of SB-728-T for HIV/AIDS 2Uni.H.A. in France Signs Purchasing Agreement for Masimo SET(R) Pulse Oximetry Products 2Uni.H.A. in France Signs Purchasing Agreement for Masimo SET(R) Pulse Oximetry Products 3Uni.H.A. in France Signs Purchasing Agreement for Masimo SET(R) Pulse Oximetry Products 4
... , , , , , , , ...y and reproducibility of,absolute protein quanti...ion,with the Protein 200 Plus assay to the batch...denaturing gel-elctrophoresis (SDSPAGE).,The res...ides,fast and reliable absolute quantitation dat...
... , , , , , , , ...ion,technology, the development,of a fully aut...signed to integrate,sample preparation, fluid ha...,is revolutionizing life science research. ,,...emiconductor-like micro-fabrication,techniques t...
... , , , , , , , ,...n designed as a precise, fast, and simple, ...poptotic cell death at, the single-cell lev..., method. , , , , , ,...optosis, DNAse activity not only generates double-...
Other Biology Technology:Comparison of different protein,quantitation methods 2Comparison of different protein,quantitation methods 3Comparison of different protein,quantitation methods 4Comparison of different protein,quantitation methods 5Comparison of different protein,quantitation methods 6Comparison of different protein,quantitation methods 7Comparison of different protein,quantitation methods 8Comparison of different protein,quantitation methods 9Agilent 2100 Bioanalyzer,Automated Analysis System 2Agilent 2100 Bioanalyzer,Automated Analysis System 3Agilent 2100 Bioanalyzer,Automated Analysis System 4Agilent 2100 Bioanalyzer,Automated Analysis System 5Agilent 2100 Bioanalyzer,Automated Analysis System 6In Situ Cell Death Detection Kit 2
...Maker System is optimized for maximum packaging ef... with any bacteriophage l vector. Using a test ins...0^7 pfu/g arms (> 4 x 10^8 pfu/g ligated l control... is extremely easy to use; simply add up to 5 g of...
BD BioCoat Laminin 150 mm Culture Dishes from BD Biosciences - Discovery Labware
Mouse Anti-Desmoplakin I & II Monoclonal Antibody, Unconjugated, Clone DP2.15 from Meridian Life Science, Inc.
FluorSave Reagent from Calbiochem
Biology Products: