Navigation Links
Report lists top 20 most-vulnerable African carnivores

s for thinking about the problem," he said. "There was no picture in any detail of what any part of this protein looks like."

Many labs have been working toward developing that picture, but the task has proven challenging. That's because the enzyme tends to clump together once outside of cells, preventing it from forming the ordered crystals necessary for structural studies. Scientists from Cech's lab and others had tried to simplify matters by crystallizing a portion of the protein, but the segments that they selected clumped together just as stubbornly as the whole enzyme.

Jacobs, a Damon Runyon Cancer Research Foundation fellow in Cech's lab and the first author of the paper, developed a new approach. With the help of bacteria and a protein that emits green fluorescent light, Jacobs randomly screened tens of thousands of fragments of the enzyme for one that would lend itself to successful structural analysis. His strategy took advantage of the fact that when multiple copies of the fluorescent protein clump together, the fluorescence is quenched, or extinguished. So Jacobs engineered bacteria to produce fragments of the telomerase enzyme fused to the fluorescent protein. Since telomerase fragments that clustered together would drag along ?and quench ?their associated fluorescent protein, Jacobs knew that any bright green bacterial colonies were producing protein fragments that remained free. Those rare colonies would be the best candidates for further analysis.

Jacobs performed these experiments on fragments of the telomerase enzyme from a variety of organisms, and found that only a fragment from Tetrahymena -- the single-celled organism in which telomerase was first discovered -- would work. The researchers named the protein fragment "telomerase essential N-terminal" (TEN) domain, in reference to its position within the complete enzyme. It took a few more biochemical tricks, but eventually Jacobs crystallized the protein fragmen
'"/>

Source:Wildlife Conservation Society


Page: 1 2 3 4

Related biology news :

1. Report that delayed motherhood decreases life expectancy of mouse offspring
2. AIDS Public Awareness Campaign Expands Following Report Of Rapidly Progressive HIV
3. Report focuses on challenges to unlocking future promise of vaccines
4. Report finds cruise industry is protecting the precious places it visits
5. Report shows deforestation threatens Brazils Pantanal
6. Report focuses on the role good microbes play in future medicine
7. Report warns about carbon dioxide threats to marine life
8. Report highlights change in Canadas forests
9. Report calls for improved monoclonal antibodies against solid tumors
10. New tool helps blood specialists improve patient care
11. New push for public health, AIDS spending at African Union summit
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Report lists top most vulnerable African carnivores

(Date:9/23/2014)... 2014 Research and Markets  has announced ... and Opportunities, 2019" report to their offering. ... enhancing security and protection in private as well as ... country,s government is focusing on using biometric systems to ... national IDs that are of crucial importance to the ...
(Date:9/23/2014)... CORAL SPRINGS, Florida , September 23, 2014 ... listings for innovative companies in tech sector position for significant ... generation products & services.  Companies in focus today are: NXT-ID, ... (NYSE: BABA ), Mobileye N.V. (NYSE: ... ReWalk Robotics Ltd. (NASDAQ: RWLK) NXT-ID, Inc. (NASDAQ: ...
(Date:9/23/2014)... have parasitic DNA fragments called "jumping genes" that insert ... process. And that phenomenon can result in age-related diseases ... Rochester now report that the "jumping genes" in mice ... protein stops keeping them in check in order to ... published today in Nature Communications , Professor of ...
Breaking Biology News(10 mins):India Biometrics Market Forecast and Opportunities, 2019 2India Biometrics Market Forecast and Opportunities, 2019 3Latest Blockbuster IPOs and Up Listings for Global Tech Stocks Attracting Major Attention as Traders Focus on Key Economic Data Due this Week 2Latest Blockbuster IPOs and Up Listings for Global Tech Stocks Attracting Major Attention as Traders Focus on Key Economic Data Due this Week 3Latest Blockbuster IPOs and Up Listings for Global Tech Stocks Attracting Major Attention as Traders Focus on Key Economic Data Due this Week 4Latest Blockbuster IPOs and Up Listings for Global Tech Stocks Attracting Major Attention as Traders Focus on Key Economic Data Due this Week 5Latest Blockbuster IPOs and Up Listings for Global Tech Stocks Attracting Major Attention as Traders Focus on Key Economic Data Due this Week 6Latest Blockbuster IPOs and Up Listings for Global Tech Stocks Attracting Major Attention as Traders Focus on Key Economic Data Due this Week 7A multi-function protein is key to stopping genomic parasites from 'jumping' 2
... the 20th EORTCNCIAACR Symposium on "Molecular Targets and ... from Tuesday 21 October-Friday 24 October. Today ... accommodation via the official local agent if you ... the European Organisation for the Research and Treatment ...
... national trial of a catheter-based treatment for deep ... in combination with clot removal devices to prevent ... of a blood clot in a leg vein). ... permanent damage to the veins, resulting in debilitating ...
... Wayne State University have tested a breast cancer vaccine ... even cancers resistant to current anti-HER2 therapy - without ... 15 issue of Cancer Research, a journal ... vaccine could treat women with HER2-positive, treatment-resistant cancer or ...
Cached Biology News:Media invitation: 20th EORTC-NCI-ACR Symposium on Molecular Targets and Cancer Therapeutics 2Pivotal national trial uses newest interventional radiology treatment to bust blood clots in legs 2Pivotal national trial uses newest interventional radiology treatment to bust blood clots in legs 3Vaccine against HER2-positive breast cancer offers complete protection in lab 2Vaccine against HER2-positive breast cancer offers complete protection in lab 3
(Date:9/23/2014)... York , September 23, 2014 ... leading provider of  Closed System Transfer     Devices ... exclusive partnership with Taiwanese distributor MedFront Medical Technology Corporation.  Equashield,s ... in Taiwan , ... as the company continues to expand globally, and ...
(Date:9/23/2014)... 23, 2014 Dr. Williams says, “Find ... on healthcare offers a three phase process that can ... delivery system that would go far beyond anything previously ... the delivery of healthcare.” , “Every effort to improve ... to provide discernable progress throughout that system because all ...
(Date:9/23/2014)... England , September 23, 2014 ... launched with funding from Imperial Innovations, Cambridge Innovation Capital ... Inivata, a clinical cancer genomics company focused on ... analysis to improve cancer testing and treatment, today ... round led by Imperial Innovations and including Cambridge ...
(Date:9/22/2014)... and SANTA CLARA, Calif. , Sept. ... WBMD ), the leading source of health information, ... survey that provide novel insights regarding physician and ... and care.  Dr. Eric Topol , a leading ... who serves as both Editor-in-Chief of Medscape and Chief ...
Breaking Biology Technology:Equashield Enters Taiwan Following Expansion to Australia, Japan, China 2Dr. Ira Williams Offers the Healthcare Solution Necessary for Patient Safety Improvement 2Inivata Raises £4m to Realise the Potential of ctDNA Analysis to Improve Cancer Treatment Through Simple Blood Tests 2Inivata Raises £4m to Realise the Potential of ctDNA Analysis to Improve Cancer Treatment Through Simple Blood Tests 3Inivata Raises £4m to Realise the Potential of ctDNA Analysis to Improve Cancer Treatment Through Simple Blood Tests 4WebMD/Medscape Digital Technology Survey Reveals Unique Insights Into How Patients and Physicians Perceive the Role, Potential and Risks Associated with Digital Health Technologies 2WebMD/Medscape Digital Technology Survey Reveals Unique Insights Into How Patients and Physicians Perceive the Role, Potential and Risks Associated with Digital Health Technologies 3WebMD/Medscape Digital Technology Survey Reveals Unique Insights Into How Patients and Physicians Perceive the Role, Potential and Risks Associated with Digital Health Technologies 4
... Scheduled for Thursday, May 15th at 5 PM ... ... IMRX ) today announced that the Company has postponed its live,webcast and ... quarter 2008 financial results; this call was originally,scheduled for Tuesday, May 13, 2008, ...
... Interleukin Genetics,Inc. (Amex: ILI ) announced today that ... Rodman and Renshaw 5th Annual Global,Healthcare Conference on Monday ... The conference will be held at Le Meridien Beach ... of the presentation will be available on the,Investors section ...
... BETHLEHEM, Pa., May 13 Particle Sciences has expanded,its ... ft Class 1000 (ISO 6),clean room. The space also ... was added to the existing 15,000 sq ft facility ... manufacturing,especially that of semisolids, suspensions and dispersions. "This,investment is ...
Cached Biology Technology:Interleukin Genetics to Present at Rodman & Renshaw 5th Annual Global Healthcare Conference 2
... BacMagic™ DNA Kit provides a positive selection ... recombinant protein expression in insect cells. The ... generating recombinant baculoviruses by eliminating the time-consuming ... is an AcNPV genome with a portion ...
... CLS number is a new product number, ... If showing no availability yet, please order ... contact customer service for assistance. ... Dim: surface area 500 cm 2 ...
Mouse Anti-Human Killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 (KIR2DL4 Monoclonal Antibody Family: New...
Gridded Cell Culture Petri Dish (20 mm molded in base), tissue-culture treated...
Biology Products: