Navigation Links
Report lists top 20 most-vulnerable African carnivores

Scientists have determined the detailed structure of an essential piece of the telomerase enzyme, an important contributor to the vast majority of human cancers. Understanding the physical shape of the protein has led to a better understanding of how it acts to immortalize cells ?and should help scientists design broadly effective cancer drugs.

Until now, the lack of detailed structural information about the enzyme has hindered progress in developing agents to inhibit it, say the researchers, who published their findings in an advance online publication in Nature Structural & Molecular Biology on February 5, 2006. Howard Hughes Medical Institute President Thomas R. Cech, whose laboratory is at the University of Colorado at Boulder, led the study, conducted with colleagues Steven A. Jacobs and Elaine R. Podell.

Cancer researchers have long sought a way to subdue telomerase, an enzyme whose excessive activity contributes to the unchecked growth of as many as 90 percent of human tumors. The enzyme is vital for some rapidly dividing cells ?such as those in a developing embryo ? where it extends telomeres, the regions of highly repetitive DNA found at the ends of chromosomes. In most healthy adult cells, telomerase is shut off, and telomeres slowly shrink during cell division ?a normal process that helps limit cells' lifespan. Cancer cells, however, usually find a way to turn telomerase back on, achieving a dangerous immortality.

"Getting telomeres replicated again is required for carcinogenesis to proceed," Cech explained. "It's an essential step in the development of cancer, and that makes it of a lot of interest therapeutically, because it is a target that could impact a wide variety of cancers."

Telomerase inhibitors have been in clinical development for many years, but, Cech said, progress has been slow. "The development of anti-telomerase chemotherapeutics has been challenged by the fact that there was no structural basi
'"/>

Source:Wildlife Conservation Society


Page: 1 2 3 4

Related biology news :

1. Report that delayed motherhood decreases life expectancy of mouse offspring
2. AIDS Public Awareness Campaign Expands Following Report Of Rapidly Progressive HIV
3. Report focuses on challenges to unlocking future promise of vaccines
4. Report finds cruise industry is protecting the precious places it visits
5. Report shows deforestation threatens Brazils Pantanal
6. Report focuses on the role good microbes play in future medicine
7. Report warns about carbon dioxide threats to marine life
8. Report highlights change in Canadas forests
9. Report calls for improved monoclonal antibodies against solid tumors
10. New tool helps blood specialists improve patient care
11. New push for public health, AIDS spending at African Union summit
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Report lists top most vulnerable African carnivores

(Date:7/29/2014)... some good news for parents of preterm babies latest ... by the time they become teenagers, the brains of many ... at term. , A study conducted by the University,s ... the preterm child experiences no brain injury in early life, ... good as their term-born peers. , However, the results of ...
(Date:7/29/2014)... it affects 1 in 100,000 people characterized by ... its cause remains unknown, a new study by a team ... Bonn in Germany and other European institutions confirms for the ... published on 6 July in Nature Genetics , is ... we swallow, a sphincter in the lower esophagus opens, allowing ...
(Date:7/29/2014)... A new study from UC San Francisco is the ... stressors accumulate overtime and accelerate cellular aging, these negative ... exercising and sleeping well. , "The study participants ... telomere shortening than the ones who didn,t maintain healthy ... said lead author Eli Puterman, PhD, assistant professor in ...
Breaking Biology News(10 mins):Preterm children's brains can catch up years later 2Mysterious esophagus disease is autoimmune after all 2Healthy lifestyle may buffer against stress-related cell aging, study says 2
... breathing problems after birth, and rare, inherited DNA differences may ... Medicine in St. Louis. The study is the first ... associated with a significant number of cases of respiratory distress ... RDS is the most common respiratory problem in newborns and ...
... Putnam Valley, NY. (Nov. 27, 2012) A ... Cell Transplantation (21:8), now freely available on-line ... mesenchymal cells derived from skeletal muscle (SM-MSCs) or ... muscle (myocardium) of separate groups of laboratory rats ...
... scientists from the University of Navarra and the Catalan Association ... Maestrazgo caves in Teruel, Spain. Their description has been published ... to one of the most ancient animal species on the ... a region of the Iberian Range where fauna has not ...
Cached Biology News:Gene linked to respiratory distress in babies 2Gene linked to respiratory distress in babies 3Study suggests different organ-derived stem cell injections improve heart function 2Three new arthropod species have been found in the Maestrazgo Caves in Teruel 2
(Date:7/29/2014)... Denver, CO (PRWEB) July 29, 2014 ... and soiled linen collection and transport solutions for hospitals, ... Society for Healthcare Engineering (ASHE) Annual Conference & Technical ... TransVac will present its technology for making hospitals cleaner, ... operational costs over the hospital’s life cycle. Staff ...
(Date:7/29/2014)... July 29, 2014 Genera ... feedstock supply innovation and supply chain advancements, has ... management systems, Energy Grange™ and Supply ASSURE™. ... and in-the-field testing aimed at consolidating and simplifying ... to landowners, farmers and feedstock end users. , ...
(Date:7/29/2014)... Quorum Review IRB, the industry leader ... by the International Association of Six Sigma ... Deployment Program. The citation recognizes robust organizational enhancements ... Lean Six Sigma program was evaluated by IASSC ... designation is a public statement of excellence and ...
(Date:7/29/2014)... 29, 2014 The first product launch ... generation approach to robotics. What sets Droidles completely apart ... technology that allows them to communicate, share code with ... the internet. , “The invention is the system,” said ... Droidles a life of their own, both physically and ...
Breaking Biology Technology:TransVac Presents Cost Saving Technology at ASHE Conference for Keeping Hospitals Cleaner 2Genera Energy Introduces Proprietary Feedstock Management Systems 2Genera Energy Introduces Proprietary Feedstock Management Systems 3Genera Energy Introduces Proprietary Feedstock Management Systems 4Quorum Review IRB Accredited by IASSC for Lean Six Sigma Deployment Program 2Quorum Review IRB Accredited by IASSC for Lean Six Sigma Deployment Program 3Droidles, the Social Network of Robots and Open Source Platform for the Internet of Things, Launches for Crowd Funding on IndieGoGo.com 2
... 2011 Landauer, Inc. (NYSE: LDR ... monitoring and the leading domestic provider of outsourced medical physics ... quarter ended March 31, 2011.   Fiscal 2011 ... to $32.3 million on contribution from Medical Physics segment and ...
... N.J., May 3, 2011 BioNeutral Group, Inc. ... today announced that it has signed on to ... disinfectant technology to the infection control professionals attending ... in Infection Control and Epidemiology) ( www.apic.org ). ...
... Inc. (Nasdaq: VVUS ), a biopharmaceutical company dedicated to ... financial results for the first quarter ended March 31, 2011. ... 2011, VIVUS reported a net loss of $9.9 million or $0.12 ... or $0.23 per share for the first quarter of 2010. The ...
Cached Biology Technology:Landauer, Inc. Reports Fiscal 2011 Second Quarter Results 2Landauer, Inc. Reports Fiscal 2011 Second Quarter Results 3Landauer, Inc. Reports Fiscal 2011 Second Quarter Results 4Landauer, Inc. Reports Fiscal 2011 Second Quarter Results 5Landauer, Inc. Reports Fiscal 2011 Second Quarter Results 6Landauer, Inc. Reports Fiscal 2011 Second Quarter Results 7Landauer, Inc. Reports Fiscal 2011 Second Quarter Results 8Landauer, Inc. Reports Fiscal 2011 Second Quarter Results 9Landauer, Inc. Reports Fiscal 2011 Second Quarter Results 10Landauer, Inc. Reports Fiscal 2011 Second Quarter Results 11Landauer, Inc. Reports Fiscal 2011 Second Quarter Results 12BioNeutral to Premier its EPA-Approved Ygiene® 206 Hospital-Grade Disinfectant at the Annual 2011 APIC Conference, While Community Health of South Florida Begins Product Review 2BioNeutral to Premier its EPA-Approved Ygiene® 206 Hospital-Grade Disinfectant at the Annual 2011 APIC Conference, While Community Health of South Florida Begins Product Review 3BioNeutral to Premier its EPA-Approved Ygiene® 206 Hospital-Grade Disinfectant at the Annual 2011 APIC Conference, While Community Health of South Florida Begins Product Review 4VIVUS Reports First Quarter 2011 Financial Results 2VIVUS Reports First Quarter 2011 Financial Results 3VIVUS Reports First Quarter 2011 Financial Results 4VIVUS Reports First Quarter 2011 Financial Results 5
... For the ultimate in utility and ... to meet the needs of the researcher. ... interior dimensions or as sheet material that ... enclosures. These isolators are autoclavable and non-cytotoxic ...
2,4-Dinitrophenyl hapten is conjugated to Human Serum Albumin (HSA) protein through lysine....
IC50: 3 ng/ml · Limit of detection: 0.5 ng/ml...
Antibodies were affinity purified using epitopes specific to PPP1CC immobilized on solid support....
Biology Products: