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Report calls for improved monoclonal antibodies against solid tumors

ss to all viable cells within tumors at sufficient concentrations to effect a maximal change in the tumor.?This is affected by several factors, including the characteristics of the tumor, the antibody, and the target. “The complexity of this problem?can be illustrated in the authors?discussion of antibody affinity. If an antibody binds too tightly to a surface antigen, the antibody will get stuck in the periphery of the tumor and be ineffective except in that location. But if an antibody binds too loosely, it may not stay in the tumor long enough to be effective at all.

The authors reviewed the literature to illustrate that the groundwork has been laid to overcome these barriers. Researchers, including Dr. Weiner, have made significant advances to understand the optimal antibody affinities required for maximum penetration, even taking into account tumor size. Studies have also investigated the optimal antibody size, shape and charge to penetrate certain types of solid tumors. Researchers have also examined how antibodies, including monoclonal therapies, behave in the human body; to understand how and how often therapies should be administered.

Given these advances in our knowledge, the authors write, “an equally large number of antibody construct and therapy variables are available for optimization including size, charge, and valence; constant region type and glycosylation pattern; presence or absence of a radioisotope or a toxic moiety; dose, route, and schedule of administration; and use of a traditional or of a pre-targeting strategy.?They conclude the framework they offer “should facilitate critical choices among antibody constructs in clinical practice, clinical research, and preclinical research.?
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Source:John Wiley & Sons, Inc.


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