Navigation Links
Report calls for improved monoclonal antibodies against solid tumors

ss to all viable cells within tumors at sufficient concentrations to effect a maximal change in the tumor.?This is affected by several factors, including the characteristics of the tumor, the antibody, and the target. “The complexity of this problem?can be illustrated in the authors?discussion of antibody affinity. If an antibody binds too tightly to a surface antigen, the antibody will get stuck in the periphery of the tumor and be ineffective except in that location. But if an antibody binds too loosely, it may not stay in the tumor long enough to be effective at all.

The authors reviewed the literature to illustrate that the groundwork has been laid to overcome these barriers. Researchers, including Dr. Weiner, have made significant advances to understand the optimal antibody affinities required for maximum penetration, even taking into account tumor size. Studies have also investigated the optimal antibody size, shape and charge to penetrate certain types of solid tumors. Researchers have also examined how antibodies, including monoclonal therapies, behave in the human body; to understand how and how often therapies should be administered.

Given these advances in our knowledge, the authors write, “an equally large number of antibody construct and therapy variables are available for optimization including size, charge, and valence; constant region type and glycosylation pattern; presence or absence of a radioisotope or a toxic moiety; dose, route, and schedule of administration; and use of a traditional or of a pre-targeting strategy.?They conclude the framework they offer “should facilitate critical choices among antibody constructs in clinical practice, clinical research, and preclinical research.?
'"/>

Source:John Wiley & Sons, Inc.


Page: 1 2

Related biology news :

1. Report that delayed motherhood decreases life expectancy of mouse offspring
2. AIDS Public Awareness Campaign Expands Following Report Of Rapidly Progressive HIV
3. Report focuses on challenges to unlocking future promise of vaccines
4. Report finds cruise industry is protecting the precious places it visits
5. Report shows deforestation threatens Brazils Pantanal
6. Report lists top 20 most-vulnerable African carnivores
7. Report focuses on the role good microbes play in future medicine
8. Report warns about carbon dioxide threats to marine life
9. Report highlights change in Canadas forests
10. Johns Hopkins flu expert calls for mandatory vaccination of health care workers
11. Empty nester parent birds use recruitment calls to extend offspring care
Post Your Comments:
(Date:5/24/2013)... 24, 2013 A frequently expressed concern in the ongoing ... fresh vegetables, especially those that are nutrient dense. ... and Beans Provide Most Nutrients Per Penny," published in ... are one of the best nutritional values in the ... per penny than most other raw vegetables and delivering ...
(Date:5/24/2013)... detection and destruction by the immune system. Stimulation of ... however, there are many factors that cause the immune ... immune cells that function to suppress the immune system ... Clinical Investigation , researchers led by Ronald Levy at ... tumors express proteins that can be targeted with therapeutic ...
(Date:5/24/2013)... against Alzheimer,s disease, scientists have focused among other factors ... After all, it is the accumulation of A-beta that causes ... point for the formation of A-beta is APP. Alessia Soldano ... the function of APPL the fruit-fly version of APP ... Alessia Soldano (VIB/KU Leuven): "We have discovered that APPL ensures ...
Breaking Biology News(10 mins):New research shows that potatoes provide one of the best nutritional values per penny 2A new strategy required in the search for Alzheimer's drugs? 2
... scientists start analyzing it), but it is fascinating. As we ... a sperm, a whole lot of cell division and growth, ... mix of genes from both parents. There are many startling ... and important is the transition from unfertilized egg to fertilized ...
... our planet, consisting of only DNA or RNA and a ... second most common type of organism. In our oceans they ... a better understanding of the structure and characteristics of these ... be able to determine their masses and how much these ...
... drug has been shown to improve blood flow in diseased ... attacks, a Monash University study published today reveals. , The ... in conjunction with Bayer Health Care, hopes to use the ... heart disease. , Dr. Harald Schmidt, Director of the Centre ...
Cached Biology News:Cracking the egg 2Weighty viruses 2Heart smart: new drug improves blood flow 2
(Date:5/23/2013)... , May 23, 2013  Rahal Letterman Lanigan ... human cord blood stem cell banking and therapeutics, announced ... the No. 16 Acorn Stairlifts Indy car driven by ... the remainder of the IZOD IndyCar 2013 season.   ... will work to support awareness of umbilical cord blood ...
(Date:5/23/2013)... Calif. , May 23, 2013 ... a strategic alliance with DAK Renewable Research to ... corn oil yield. VG Energy is a majority ... Pink: VGLS). VG Energy,s exclusively licensed ... increase the oil yield in plants, possessing a ...
(Date:5/23/2013)... , May 23, 2013 BioTrends Research ... advisory firms for specialized biopharmaceutical issues, finds that, ... infectious disease specialists reported that in the past ... intentionally delaying treatment) in anticipation of the next ... months ago, when only 6 percent reported that ...
(Date:5/23/2013)... 23, 2013 Northwest Biotherapeutics (NASDAQ: ... ® personalized immune therapies for solid tumor cancers, ... this year,s American Society Of Clinical Oncology (ASCO) meeting ... leadership role in immune therapy.  (Logo: ... is the pre-eminent conference focused on clinical treatment of ...
Breaking Biology Technology:StemCyte, Inc. Joins Rahal Letterman Lanigan Racing As Associate Sponsor Of No. 16 IndyCar Program For James Jakes Beginning With The 97th Indianapolis 500 2StemCyte, Inc. Joins Rahal Letterman Lanigan Racing As Associate Sponsor Of No. 16 IndyCar Program For James Jakes Beginning With The 97th Indianapolis 500 3VG Energy Enters into a Strategic Alliance with DAK Renewable Research for LipidMax Field Trials 2VG Energy Enters into a Strategic Alliance with DAK Renewable Research for LipidMax Field Trials 3The Majority of Physicians that Treat Hepatitis C Virus (HCV) Have Begun "Warehousing" and Preparing Their HCV Patients for the Next Generation of HCV Treatments 2The Majority of Physicians that Treat Hepatitis C Virus (HCV) Have Begun "Warehousing" and Preparing Their HCV Patients for the Next Generation of HCV Treatments 3NW Bio Exhibit at the Upcoming ASCO Meeting to Highlight its Leadership Role in Immune Therapy for Cancer 2NW Bio Exhibit at the Upcoming ASCO Meeting to Highlight its Leadership Role in Immune Therapy for Cancer 3
... which bounced to a near pinpoint landing inside a ... seven-month flight, promises a trove of new data about ... a UW-Madison professor of geology and geophysics who has ... Mars, expects the latest mission to add considerably to ...
... Wis. - GE Medical Systems and University Community Health ... based in Tampa, Florida have announced an agreement to build ... Medical Systems will be the technology provider for UCH's ... Southeast using advanced digital technology, when it opens in the ...
... has many great assets for building a thriving high technology ... at the University of Wisconsin-Madison . Yet we ... we have lacked one vital ingredient: venture capital to support ... ,According to the National Venture Capital Association , Wisconsin, ...
Cached Biology Technology:GE Medical Enables Digital Heart Hospital 2GE Medical Enables Digital Heart Hospital 3Wisconsins VC Challenge 2Wisconsins VC Challenge 3
... the ultimate in utility and flexibility press-to-seal ... the needs of the researcher. They are ... or as sheet material that can be ... isolators are autoclavable and non-cytotoxic and can ...
Argon Calibration Source...
SHEEP ANTI ESCHERICHIA COLI...
Recombinant Rat Leptin, CF...
Biology Products: