Navigation Links
Report calls for improved monoclonal antibodies against solid tumors

A new report by leading experts in monoclonal antibody research for oncology offers a conceptual framework for future research in the design of antibody therapies against solid tumors. Writing in the January 15, 2007 issue of CANCER (http://www.interscience.wiley.com/cancer-newsroom), a peer-reviewed journal of the American Cancer Society, the researchers note that 85 percent of cancers involve solid tumors, but only 25 percent of approved antibody therapies are directed at solid tumor targets. The researchers suggest manipulation of the physical properties of a monoclonal antibody as a potentially effective way to improve antibody treatments for solid tumors.

Monoclonal antibodies?ability to target a single specific protein on cancer cells, has led to their being called a “magic bullet?that targets only cancer cells while minimizing collateral damage to healthy tissue. That damage causes the toxicity associated with chemotherapy and radiation therapy. In the nearly 20 years since scientists were able to create monoclonal antibodies that could be safely used in humans, eight monoclonal antibodies have been approved for use in clinical treatments to trigger immune responses to cancer cells, modulate cancer cell growth, and deliver drugs to cancer cells. Of these, only three are used on solid tumors. However, solid tumors account for 85 percent of all cancers.

According to review lead author Robert A. Beckman, M.D. of the Department of Clinical Hematology and Oncology at Centocor Research & Development, Inc. in Malvern, PA and his co-authors, Louis M. Weiner, M.D. of Fox Chase Cancer Center in Philadelphia and Hugh M. Davis, Ph.D. of the Department of Clinical Pharmacology and Experimental Medicine at Centocor, a major difficulty in developing monoclonal antibody treatments for solid tumors has been their ability to penetrate the tumor. To be effective, the treatment “must gain acce
'"/>

Source:John Wiley & Sons, Inc.


Page: 1 2

Related biology news :

1. Report that delayed motherhood decreases life expectancy of mouse offspring
2. AIDS Public Awareness Campaign Expands Following Report Of Rapidly Progressive HIV
3. Report focuses on challenges to unlocking future promise of vaccines
4. Report finds cruise industry is protecting the precious places it visits
5. Report shows deforestation threatens Brazils Pantanal
6. Report lists top 20 most-vulnerable African carnivores
7. Report focuses on the role good microbes play in future medicine
8. Report warns about carbon dioxide threats to marine life
9. Report highlights change in Canadas forests
10. Johns Hopkins flu expert calls for mandatory vaccination of health care workers
11. Empty nester parent birds use recruitment calls to extend offspring care
Post Your Comments:
(Date:10/17/2014)... in German . ... day in order to reproduce? And why are there two ... the latest issue of the research journal Molecular Human ... Steven Ramm from Bielefeld University Bielefeld has compiled this special ... for a female to copulate with several males in quick ...
(Date:10/16/2014)... land managers have a new synthesis of recent research ... (MMC) forests in the two states. , The ... Oregon and Washington: A Synthesis of the Relevant Biophysical ... technical report published by the U.S. Forest Service,s Pacific ... request from managers for a synthesis of the large ...
(Date:10/16/2014)... October 16, 2014 NXT-ID, Inc. (NASDAQ: ... a biometric authentication company focused on the growing mobile ... technologies including Wocket™, the Smart Wallet, at the 13 ... is a leading global conference on the intersection of ... Mark Anderson , founder and publisher of the ...
Breaking Biology News(10 mins):Sperm wars 2New report synthesizes best available science on management of moist mixed-conifer forests 2NXT-ID Inc. to Present at 13th Annual FiRe Conference 2NXT-ID Inc. to Present at 13th Annual FiRe Conference 3
... ST. LOUIS A group of 50 researchers from around ... Louis University and Leslie Buck, Ph.D., from the University of ... the genome of the western painted turtle and the results ... be important for human health. The western painted turtle, ...
... Park Ridge, Ill. (April 23, 2013) This ... the world are gathering to share research on a ... growing global burden of chronic disease, there is particular ... in overall health. Several studies presented at the conference ...
... reefs are stressed the world over and could be in ... corals die and others not, even when exposed to the ... University and The Field Museum of Natural History has a ... susceptibility to deadly coral bleaching due to the light-scattering properties ...
Cached Biology News:Saint Louis University, University of Toronto biologists help decode turtle genome 2New research points to benefits of eggs, even for those at cardiovascular risk 2Insights into deadly coral bleaching could help preserve reefs 2Insights into deadly coral bleaching could help preserve reefs 3
(Date:10/19/2014)... Asian Automatic patient billing report defines and segments the ... The Automatic patient billing market in Asia is estimated ... a developing CAGR of 7.2% from 2013 to 2018. ... patient billing market, to get an idea of the ... the segmentation of this market in the same region, ...
(Date:10/19/2014)... (PRWEB) October 19, 2014 According ... Products (Access Points; WLAN Controllers; Wireless gateways)]- Global ... and segments the global Outdoor Wi-Fi market with ... this report MarketsandMarkets also identifies the drivers and ... on the trends, opportunities and challenges. , Browse ...
(Date:10/18/2014)... The Asia-Pacific hardware encryption display market ... with analysis and forecast of revenue. This market was ... reach $51,362.6 million by 2018, at a CAGR of ... TOC of the Asia-Pacific hardware encryption market report, to ... also provides a glimpse of the segmentation of the ...
(Date:10/18/2014)... The report " Cloud Analytics Market ... Speech; Machine; Video; Predictive Analytics: Global Advancements, Delivery ... Analysis (2013 - 2018) ", defines and segments ... segments with an in-depth analysis and forecasting of ... driving this market, various restraints, and opportunities impacting ...
Breaking Biology Technology:The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 2The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 3Outdoor Wi-Fi Market (by Access Points, WLAN Controllers, Wireless gateways) Expected to Cross $37.2 Billion by 2018 - New Report by MarketsandMarkets 2Outdoor Wi-Fi Market (by Access Points, WLAN Controllers, Wireless gateways) Expected to Cross $37.2 Billion by 2018 - New Report by MarketsandMarkets 3Outdoor Wi-Fi Market (by Access Points, WLAN Controllers, Wireless gateways) Expected to Cross $37.2 Billion by 2018 - New Report by MarketsandMarkets 4The Asia-Pacific hardware encryption display market is expected to reach $51,362.6 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific hardware encryption display market is expected to reach $51,362.6 million by 2018 - New Report by MicroMarket Monitor 3Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 2Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 3Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 4Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 5
... desktops, laptops, MP3 players and smartphones are a likely ... digital audio (or video) programs are delivered via ... a range of devices for on-demand listening. , ... consumers for a variety of reasons providing an ...
... Madison, Wis. - The U.S. District Court for ... injunction against Abbott Laboratories , preventing the pharmaceutical company ... infringe on a genotyping patent held by Innogenetics , ... comes after the court upheld a $7 million damage verdict ...
... - When it comes to innovation, American Family Insurance's ... , Chapman The direction comes from within, and ... it up with a familiar phrase: nothing ventured, nothing gained. ... established a venture program modeled after employee-driven, quality-control programs. ...
Cached Biology Technology:Podcasts time, place, and player shifted media 2Podcasts time, place, and player shifted media 3Podcasts time, place, and player shifted media 4CIO Leadership Series: Byrne Chapman, American Family Insurance 2CIO Leadership Series: Byrne Chapman, American Family Insurance 3CIO Leadership Series: Byrne Chapman, American Family Insurance 4