Navigation Links
Renewed hope for Parkinson's patients

Research led by biologists at the University of California, Berkeley, has found that damage to a cell's DNA sets off a chain reaction that leads to the increased expression of a marker recognized by the body's immune system.

The new findings, to be published July 3 in an advanced online issue of Nature, shed light on a long-standing question of how the natural killer (NK) cells - which are able to attack tumors - can differentiate cells that are cancerous from those that are healthy.

"Our study is the first to show that there are mechanisms in place for the immune system to identify cancer cells," said Stephan Gasser, UC Berkeley post-doctoral researcher in molecular and cell biology and lead author of the paper. "It reveals how natural killer cells distinguish something they're supposed to get rid of versus something they're supposed to keep."

The researchers explain that the immune system is designed to detect and attack foreign invaders, but cancer cells present a special challenge because they are still the bodies own cells, albeit ones in which the genes have gone awry.

"Many scientists question the importance of the immune system in stemming the development of cancer," said David H. Raulet, professor of immunology at UC Berkeley's Department of Molecular and Cell Biology and senior investigator of the study. "Our research adds to recent evidence that the immune system plays a significant role."

The researchers put cultures of ovarian epithelial cells and fibroblasts from mice through a battery of abuse, including heat shock, pH changes, oxygen deprivation and starvation. However, the only type of stress that set off the sequence of events associated with impairment of a cell's genetic material -- the DNA damage pathway -- was exposure to radiation and chemotherapy drugs.

They found that cells in which the DNA damage pathway was triggered were the ones that exhibited an increase in the expression of special protein
'"/>

Source:University of Bristol


Page: 1 2 3

Related biology news :

1. Renewed dolphin slaughter prompts new campaign
2. Scientists detect probable genetic cause of some Parkinsons disease cases
3. Gene Therapy For Parkinsons Disease Moves Forward In Animals
4. Duke Chemists Isolating Individual Molecules Of Toxic Protein In Alzheimers, Parkinsons Disease
5. Gene therapy for Parkinsons disease moves forward in animals
6. Neurologix announces positive results of gene therapy clinical trial in Parkinsons disease
7. Amphetamines reverse Parkinsons disease symptoms in mice
8. UCLA scientists find male gene in brain area targeted by Parkinsons
9. Gene therapy turns off mutation linked to Parkinsons disease
10. Key stress protein linked to toxicities responsible for Parkinsons, Alzheimers
11. Parkinsons disease mechanism discovered
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Renewed hope for Parkinson patients

(Date:11/21/2014)... , Nov. 20, 2014 C-Labs LLC, a ... Internet of Things (IoT), today announced the appointment of ... operating officer. Previously a strategic advisor to the firm, ... operations. Mr. Traynor is based out of the C-Labs ... reports to Chris Muench , Chief Executive Officer. ...
(Date:11/18/2014)... WASHINGTON , Nov. 18, 2014  The ... Security Industry Association today jointly announce the formation ... and release of its Identity and Biometric ... (Framework). The Framework received official support from BORDERPOL, ... governments to improve and provide expertise regarding border ...
(Date:11/18/2014)... Nov. 17, 2014 The Parenteral Drug Association (PDA) ... agencies will speak and at least seven more will participate ... the Omni Shoreham Hotel in Washington D.C. ... to have significant support from the regulatory agencies in ... in our effort to help advance the use ...
Breaking Biology News(10 mins):C-Labs Names Former Microsoft and Bsquare Executive as Chief Operating Officer 2Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 2Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 3FDA's Janet Woodcock, EMA's Emer Cooke Headline PDA Quality Metrics Conference 2
... BEDFORD, Mass., April 1, 2011 Aware, Inc. (NASDAQ: ... for the telecommunications and biometrics industries, today announced that Edmund ... and Chief Executive Officer and director of the board of ... Moberg, CFO and Kevin T. Russell, General Counsel have been ...
... for Engineering in Medicine (CEM) -- a bioengineering research ... Teaching Hospital -- has announced it will reconvene its ... organizer Horizon House Ltd.  The event, BioMethods Boston, will ... and expects to draw over 400 senior researchers from ...
... Group, Inc. (OTCBB: MDXG), an integrated developer, manufacturer and ... from human amniotic membrane, announced today the nation-wide launch ... specifically processed to offer a wide variety of wound ... the hiring of Frank Burrows as its Vice President ...
Cached Biology News:Aware, Inc. Announces Resignation of Chief Executive Officer 2Aware, Inc. Announces Resignation of Chief Executive Officer 3Massachusetts General Hospital Center Reignites Methods in Bioengineering Conference 2MiMedx Group Announces Launch of EpiFix™ and Hiring of Vice President, Wound Care 2MiMedx Group Announces Launch of EpiFix™ and Hiring of Vice President, Wound Care 3MiMedx Group Announces Launch of EpiFix™ and Hiring of Vice President, Wound Care 4
(Date:12/17/2014)... (PRWEB) December 17, 2014 Gene ... that it has entered into a technology access ... (ADM) to apply DNA2.0’s proprietary protein engineering technology, ... process. , “We are extremely excited that the ... platform. This proprietary bioengineering technology has now ...
(Date:12/17/2014)... SOUTH SAN FRANCISCO, Calif. , Dec. 17, ... positive results of a Phase 2 study evaluating ... for the treatment of patients with severe, chronic ... the current standard of care, including topical steroids ... endpoint was percent change in Visual Analog Scale ...
(Date:12/15/2014)...  GlassesOff Inc. (OTCBB: GLSO) announced today the appointment ... director of the Company,s Board of Directors. ... its CEO until its acquisition by Stanley Black ... Recognized as the inventor of the first Wi-Fi-based Active ... -based RFID solutions focused on improving operational efficiency, safety ...
(Date:12/13/2014)... (PRWEB) December 12, 2014 Clarassance, a ... announced its new name: Therabron Therapeutics , Inc. ... and bronchioles (a type of structure in the lungs ... company’s mission to develop novel protein therapeutics for the ... directors decided to change the name to mark the ...
Breaking Biology Technology:ADM and DNA2.0 Enter Into Protein Engineering Technology Access and Service Agreement 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 3Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 4AeroScout Founder Joins GlassesOff's Board of Directors 2AeroScout Founder Joins GlassesOff's Board of Directors 3Maryland-based Biotech Company's Path Forward in Treating Respiratory Diseases Sparks Name Change 2
... ARPN) today reported that it has submitted a ... intravenous iclaprim for the treatment of,complicated Skin and ... and,Drug Administration (FDA). Arpida has requested a Priority ... a synthetic diaminopyrimidine which,exhibits a rapidly bactericidal action ...
... the National Institute of Standards and Technology (NIST) have ... the microelectronics of today built from semiconductor compounds and ... molecules. In an upcoming paper in the Journal of ... a single layer of organic molecules can be assembled ...
... Inverness Medical,Innovations, Inc. (Amex: IMA ), a ... the consumer and professional markets, announced,today that as ... worldwide,operations for the purpose of lowering operating costs ... close two facilities in the San,Francisco area which ...
Cached Biology Technology:Arpida Submits New Drug Application for Intravenous Iclaprim for Treatment of Skin Infections 2Arpida Submits New Drug Application for Intravenous Iclaprim for Treatment of Skin Infections 3NIST team proves bridge from conventional to molecular electronics possible 2Inverness Medical Innovations to Close Cholestech, HemoSense and BioStar Facilities 2Inverness Medical Innovations to Close Cholestech, HemoSense and BioStar Facilities 3
... 100 IS System is a compact analysis system ... lasers, optics, fluidics, a controller, advanced digital signal ... compact lab analysis system includes the Luminex 100, ... has a DMF file at the FDA, and ...
... for routine binary separations. Excellent detection is ... UV-Visible variable wavelength detector. Ultra-fine control of ... two highly accurate and precise, high pressure dual ... Chromatograms may be plotted on a printer or ...
... cultured in Minimum Essential Medium (Eagle) with 2 ... of growth. In order to keep the ... in acetone-methanol. The cells are arrayed on ... each wells surface specifically treated to enhance cellular ...
... were cultured in RPMI 1640 with 2 mM ... growth. In order to keep the antigens ... acetone-methanol. The cells are arrayed on a ... wells surface specifically treated to enhance cellular attachment ...
Biology Products: