Navigation Links
Renegade RNA -- Clues to cancer and normal growth

Researchers at Johns Hopkins have discovered that a tiny piece of genetic code apparently goes where no bit of it has gone before, and it gets there under its own internal code.

A report on the renegade ribonucleic acid, and the code that directs its movement, will be published Jan. 5 in Science.

MicroRNAs, already implicated in cancer and normal development, latch on to and gum up larger strands of RNA that carry instructions for making the proteins that do all the cell's work. They are, says Joshua Mendell, M.D., Ph.D., an assistant professor in the McKusick-Nathans Institute of Genetic Medicine at Hopkins, like "molecular rheostats that fine-tune how much protein is being made from each gene."

That's why normally microRNAs always have appeared to stick close to the cell's protein-making machinery.

But during a survey of more than 200 of the 500 known microRNAs found in human cells, Mendell's team discovered one lone microRNA "miles away" --- in cellular terms --- from all the others.

"It was so clearly in the wrong place at the wrong time for what we thought it was supposed to be doing that we just had to figure out why," says Hun-Way Hwang, a graduate student in human genetics and contributor to the study.

Consisting of only 20 to 25 nucleotide building blocks (compared to other types of RNA that can be thousands of nucleotides long), each microRNA has a different combination of blocks. Mendell's team realized that six building blocks at the end of the wayward miR-29b microRNA were noticeably different from the ends of other microRNAs.

Suspicious that the six-block end might have something to do with miR-29b's location, the researchers chopped them off and stuck them on the end of another microRNA. When put into cells, the new microRNA behaved just like miR-29b, wandering far away from the cell's protein-making machinery and into the nucleus, where the cell's genetic material is kept.

<
'"/>

Source:Johns Hopkins Medical Institutions


Page: 1 2

Related biology news :

1. Research on Worms Yields Clues on Aging
2. New Clues Add 40,000 Years to Age of Human Species
3. Clues to breast cancer hidden inside stem cells
4. Clues to gene expression in cystic fibrosis will guide research
5. Viral DNA sequence a possible trigger for breast cancer
6. Enzyme, lost in most mammals, is shown to protect against UV-induced skin cancer
7. Its not all genetic: Common epigenetic problem doubles cancer risk in mice
8. Columbia research lifts major hurdle to gene therapy for cancer
9. Combination therapy boosts effectiveness of telomere-directed cancer cell death
10. Mitochondrial DNA mutations play significant role in prostate cancer
11. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Renegade RNA Clues cancer and normal growth

(Date:9/30/2014)... led by Clemson University associate professor Brian Powell, ... the U.S. Department of Energy,s Experimental Program to ... impact on South Carolina in the advancement of ... "Understanding the scientific and engineering needs for safely ... technologies is imperative if South Carolina is to ...
(Date:9/30/2014)... can live in almost any aquatic environment on Earth, ... many species are pushed to the limit. The amount ... prove critical for how different species cope in the ... University of Gothenburg, published in the scientific journal ... change continues apace thanks to increasing levels of greenhouse ...
(Date:9/30/2014)... When it comes to using marijuana, new research, involving ... the Journal of Leukocyte Biology , ... mean that you should. That,s because a team of ... may do serious long-term damage to the immune system. ... inflammatory diseases, such as multiple sclerosis, inflammatory bowel disease ...
Breaking Biology News(10 mins):Researchers get $5.25 million to advance nuclear technologies in South Carolina 2Shape up quickly -- applies to fish, too! 2Adolescent exposure to thc may cause immune systems to go up in smoke 2
... up to 1000 times larger than their wild relatives. ... food plants have larger fruits, heads of grain, tubers, etc, ... chose when foraging for food. In addition to size, ... nutrient composition, but it has been difficult to study these ...
... BOZEMAN Two Montana state University researchers are principal ... find noninvasive ways to study carnivores in the wild. ... was released June 27 with Robert Long and Paula ... at MSU,s Western Transportation Institute. Working with ...
... at UT Southwestern Medical Center have determined that starvation ... that may have implications in treating diabetes and extending ... blunted during starvation. But our work shows that this ... much more sophisticated than that," said Dr. Steven Kliewer, ...
Cached Biology News:Evolution of fruit size in tomato 2Evolution of fruit size in tomato 3Growth hormone's link to starvation may be clue to increasing life span, researchers find 2
(Date:9/30/2014)... (PRWEB) September 30, 2014 Proove ... medicine, is excited to announce a new genetic test ... The Proove Pain Perception Test will provide physicians ... and why pain tolerance levels are stratified between individuals. ... identify whether a person has a genetic predisposition that ...
(Date:9/30/2014)... 2014  RegeneRx Biopharmaceuticals, Inc. (OTC: RGRX) ("the ... received a Canadian Patent for Inhibition or Reversal ... includes claims using thymosin beta 4, various fragments ... these purposes.  The patent will expire in 2021. ... www.regenerx.com ) RegeneRx is focused ...
(Date:9/30/2014)... Fast, semi-automatic creation of ... documents ChemAxon , a leader ... for life science research, launches ChemCurator, an application ... from documents. Markush structures are essential ... and understanding Markush structures is a difficult and ...
(Date:9/30/2014)... Los Angeles, CA (PRWEB) September 30, 2014 ... Separation (EWS), the high-speed, chemical-free process to clean up ... letter to shareholders, CEO Riggs Eckelberry reported on the ... West Texas, at a site provided by partner ... ramped up to 1000 barrels per day (bpd) and ...
Breaking Biology Technology:Proove Biosciences is Now Offering the Proove Pain Perception Genetic Test to Help Physicians Assess Patient Pain Tolerance Levels 2Proove Biosciences is Now Offering the Proove Pain Perception Genetic Test to Help Physicians Assess Patient Pain Tolerance Levels 3RegeneRx Receives Canadian Patent for Inhibition or Reversal of Skin Aging 2ChemAxon Introduces ChemCurator for Chemical Information Extraction and Markush Structure Creation 2OriginOil, Inc. Report to Shareholders: Blue Gold in West Texas 2
... BEACH, Calif. & HAMILTON, New Zealand, Oct. 29 ... for DNA extraction and other life sciences applications, today ... VERITAS Japan to distribute ZyGEM,s DNA extraction products to ... latest in a series of recent major distribution agreements ...
... MATEO, Calif., Oct. 29 NeurogesX, Inc. (Nasdaq: ... commercializing novel pain management therapies, announced today that Anthony ... present at two upcoming conferences in New York City: ... be held November 3-4, 2009 and the Lazard Capital ...
... ... Access IR/PR, a San Diego-based investor and public relations ... consultancy based in Boston, have formed a strategic alliance. The alliance ... and provides extended access to key financial, investor and media communities ...
Cached Biology Technology:ZyGEM Strengthens its Worldwide Presence With New Distribution Agreement for Japan 2ZyGEM Strengthens its Worldwide Presence With New Distribution Agreement for Japan 3ZyGEM Strengthens its Worldwide Presence With New Distribution Agreement for Japan 4NeurogesX to Present at Two November Conferences 2NeurogesX to Present at Two November Conferences 3Investor Relations Firm Access IR/PR and The Communications Strategy Group Announce Strategic Alliance 2
Hucal Agx Antigen Expression Service Specificity: Hucal Agx ...
MHC. Sections include: the isolation and functional properties of antigen-presenting cells analysis of MHC class II endocytosis and peptide turnover analysis of signalling via MHC class II molecu...
... The 1-D PAGE ... Kit for Targeted Protein ... SDS PolyAcrylamide Gel Electrophoresis ... chemistry, and cleavable-linker technology ...
Supplemental reagent for annexin V assay....
Biology Products: