Navigation Links
Removing DNA repair gene causes metabolic syndrome

to restore DNA to its undamaged state.

"Our analysis is that the inability to repair damage to the genetic material, whether it is in the nucleus or whether it's in the mitochondria, is what's leading to a destabilization of a normal metabolic process," Lloyd said. "That then begins to cascade and ultimately results in the symptoms that are consistent with the metabolic syndrome."

Lloyd says he hopes to study individuals suffering from the metabolic syndrome with the goal of someday developing a genetic screen for the disease. He also wants to examine ways to delay the onset of symptoms, such as increasing the expression of the NEIL1 gene or dampening oxidative stress to the cells that damages their DNA. Such techniques could one day become therapies.

"One may be able to develop a diagnostic method to do early screening," Lloyd said. "Or there could be a drug discovery mechanism in which you enhance the transcription process (of NEIL1) and just make more. Maybe you only have one good copy. Fine. Maybe we can upregulate that one."

More importantly, "What we think this publication is going to do is add one more complexity to the potential mechanisms by which you could get to disease," he said.


'"/>

Source:Oregon Health & Science University


Page: 1 2 3

Related biology news :

1. Removing egg from nest may help save endangered whooping crane
2. Heart repair gets new muscle
3. Nano-bumps could help repair clogged blood vessels
4. New understanding of DNA repair may pave way to cancer treatments
5. Researchers pioneer new gene therapy technique using natural repair process
6. Circulating stem cells play small role in lung repair
7. Muscle repair: Making a good system better, faster; implications for aging, disease
8. Stressed cells spark DNA repair missteps and speed evolution
9. Scientists get first glimpse at how plants, most animals repair UV-damaged DNA
10. OHSU researchers discover potential mechanism to repair brain damage linked to Multiple Sclerosis
11. Discovering the first steps in transcription-coupled repair
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Removing DNA repair gene causes metabolic syndrome

(Date:7/31/2014)... team of scientists from Spain, France, and the ... that is the oldest definitive member of the ... amber. The discovery and description were made possible ... synchrotron imaging technique, which allows the detailed study ... new species is described in the journal ...
(Date:7/31/2014)... news release is available in German . ... can take up gases similar to a sponge that ... suited for storing hydrogen or greenhouse gases. However, loading ... Karlsruhe Institute of Technology (KIT) now report in ... cor-rosion of the MOF surface. This can be prevented ...
(Date:7/31/2014)... percent of animal models against the highly infectious and ... intestinal disease that kills approximately 30,000 Americans annually. The ... and Immunity . , In the study, the ... purified toxins produced by C. difficile , as ... model that mimics the human disease, after only two ...
Breaking Biology News(10 mins):Free pores for molecule transport 2C. difficile vaccine proves safe, 100 percent effective in animal models 2
... CLEVELAND Case Western Reserve,s Technology Transfer Office has ... (AD) treatment strategy to spinoff company ReXceptor Inc., which ... medication within the next few months. Gary Landreth, ... Neurosciences, and his then-graduate student, Paige Cramer, PhD, co-founded ...
... After years of scientific uncertainty and speculation, researchers at ... exactly how trees help create one of society,s predominant ... has long been known that trees produce and emit ... protect leaves from oxygen damage and temperature fluctuations. However, ...
... at Wake Forest University,s Organic Electronics group have come ... biggest technological barriers facing the organic semiconductor industry today. ... team of researchers developed a high performance organic semiconductor ... areas without losing electric conductivity. This is a potentially ...
Cached Biology News:Research spinoff ReXceptor gets license for Alzheimer's treatment 2Researchers pinpoint how trees play role in smog production 2High performance semiconductor spray paint could be a game changer for organic electronics 2
(Date:7/31/2014)... Calif. (PRWEB) July 31, 2014 Held ... diagnosed patients with an overview of the disease and ... of drug side effects, as well as updates on ... grateful to Dr. Sandy Srinivas for organizing this educational ... of kidney cancer. “Sandy and her colleagues have put ...
(Date:7/31/2014)... The global market for molecular diagnostics is ... to a new study by Grand View Research, Inc. ... subsequent introduction of advanced cancer diagnostic technologies are expected ... next six years. Moreover, the growing global base of ... with disease triggering lifestyle habits such as smoking and ...
(Date:7/31/2014)... IL (PRWEB) July 31, 2014 ... of automation across the U.S., increasing unemployment, depressing ... class. It is a Catch 22—we need ... but this means fewer jobs,” says economist and ... just-released Pollina Corporate Top 10 Pro-Business States for ...
(Date:7/31/2014)... (PRWEB) July 31, 2014 ... and collaboration company, is proud to announce the ... LMS complements Adobe Connect’s elearning tools to quickly ... delivers content with training tools for desktop and ... with LMS is the perfect online training solution, ...
Breaking Biology Technology:Molecular Diagnostics Market - Global Industry Size, Share, Trends, Analysis, Players, Opportunity, Outlook and Forecast From 2014 to 2020 2Molecular Diagnostics Market - Global Industry Size, Share, Trends, Analysis, Players, Opportunity, Outlook and Forecast From 2014 to 2020 3Molecular Diagnostics Market - Global Industry Size, Share, Trends, Analysis, Players, Opportunity, Outlook and Forecast From 2014 to 2020 4Molecular Diagnostics Market - Global Industry Size, Share, Trends, Analysis, Players, Opportunity, Outlook and Forecast From 2014 to 2020 5ITRA Global Affiliate’s Pollina Corporate Top 10 Pro-Business States Minimize the Impact of Automation on Middle Class and Unemployment 2ITRA Global Affiliate’s Pollina Corporate Top 10 Pro-Business States Minimize the Impact of Automation on Middle Class and Unemployment 3ITRA Global Affiliate’s Pollina Corporate Top 10 Pro-Business States Minimize the Impact of Automation on Middle Class and Unemployment 4SoundConnect Enhances Portfolio with Adobe Connect Learning Management System (LMS) 2
... AIS is a provider of browser-based policy, ... the system allows business users to maintain much ... technical resources are conserved. The combination of Fiserv ... companies to automate customer communication, provide high levels ...
... ,You did it; you brought Bill Gates to his tender knees. ... campus. 'Curses, you worm writer, you!" It echoed among the buildings, ... teeth. And beneath the whimpers you could almost hear Billy saying ... money and fix my software."* , ,Wow, if only ...
... get techies into ballgame, too , ,As the ... recent or soon-to-be college grads may view a career ... could only see what really goes on in todays ... systems, robotic welding, remote sensoring and other modern staples ...
Cached Biology Technology:Open Letter: Blasted Worm 2Open Letter: Blasted Worm 3Manufacturing still viable career 2Manufacturing still viable career 3
...
Mouse monoclonal antibody raised against a full length recombinant ATF3. NCBI Entrez Gene ID = ATF3...
... The dsRNA Marker consists of ten double-stranded ... 300, 400, 500 and 1,000 base pairs. ... marker for determinating sizes of double-stranded RNAs. ... the dsRNA Marker is adjusted to approximately ...
... raised against a partial recombinant ... HD (NP_002102, 81 a.a. ... protein with GST tag. ... NM_002111 Protein ...
Biology Products: