Navigation Links
Removing DNA repair gene causes metabolic syndrome

Removing a gene involved in repairing damaged DNA causes mice to develop the metabolic syndrome, researchers at Oregon Health & Science University have discovered.

Scientists at OHSU, the University of Texas Medical Branch and the University of Alabama found that generating mice that lack the gene encoding the DNA repair enzyme NEIL1 causes them to develop severe obesity and reach nearly twice the weight of their normal counterparts. The mice, according to the study appearing in the Proceedings of the National Academy of Sciences, also had enlarged, fatty yellow livers, insulin levels four times higher than normal, elevated levels of fat cell byproducts, and many internal organs almost entirely encased in thick pads of fatty tissue.

The results are the first to link DNA repair with the metabolic syndrome, and they suggest an important role for the NEIL1 gene product in the prevention of the diseases associated with the disorder, including obesity, hypertension, high cholesterol, insulin resistance and kidney disease.

"So if there are catalytically compromised forms of NEIL1 within the U.S. population, these people will be predicted to be at increased risk for developing the metabolic syndrome," a disease believed to affect more than 40 million Americans, said R. Stephen Lloyd, Ph.D., senior scientist at OHSU's Center for Research on Occupational and Environmental Toxicology (CROET) and co-author of the study.

Lloyd and his colleagues originally discovered the NEIL1-deficient mouse's propensity for developing the metabolic disorder about two years ago. Their interest in NEIL1 was initiated by their efforts to clone and crystallize homologs to the Escherichia coli endonuclease VIII gene. E. coli endonuclease VIII is part of a pathway of enzymes involved in repairing DNA damaged by free radicals that trigger oxidative stress on cell molecules. As a consequence of these studies, the Lloyd laboratory found human homologs to the bacteria
'"/>

Source:Oregon Health & Science University


Page: 1 2 3

Related biology news :

1. Removing egg from nest may help save endangered whooping crane
2. Heart repair gets new muscle
3. Nano-bumps could help repair clogged blood vessels
4. New understanding of DNA repair may pave way to cancer treatments
5. Researchers pioneer new gene therapy technique using natural repair process
6. Circulating stem cells play small role in lung repair
7. Muscle repair: Making a good system better, faster; implications for aging, disease
8. Stressed cells spark DNA repair missteps and speed evolution
9. Scientists get first glimpse at how plants, most animals repair UV-damaged DNA
10. OHSU researchers discover potential mechanism to repair brain damage linked to Multiple Sclerosis
11. Discovering the first steps in transcription-coupled repair
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Removing DNA repair gene causes metabolic syndrome

(Date:10/16/2014)... land managers have a new synthesis of recent research ... (MMC) forests in the two states. , The ... Oregon and Washington: A Synthesis of the Relevant Biophysical ... technical report published by the U.S. Forest Service,s Pacific ... request from managers for a synthesis of the large ...
(Date:10/16/2014)... Northridge, Calif. (October 16, 2014) – Post-menopausal women ... effect on hormone levels or genital bleeding, after ... of an investigational fermented soy germ-based nutritional supplement ... according to a new peer-reviewed pilot study reported ... Society (NAMS) annual scientific meeting. , "These ...
(Date:10/15/2014)... is a non-traditional biophysics textbook and it describes how ... journey of discovery into biological systems and provides an ... It is about how our genes make proteins that ... of cells in an organism. It quantifies the principles ... can be found on both large and small scales. ...
Breaking Biology News(10 mins):New report synthesizes best available science on management of moist mixed-conifer forests 2S-equol supplements associated with improved measures of reproductive health in postmenopausal women 2New book about life as seen from physics 2
... MIAMI African-American women with breast cancer living ... in treatment regardless of insurance type, socioeconomic status and ... A. Young, Ph.D., an associate professor of epidemiology at ... difficulties in measuring the impact of race and socioeconomic ...
... , BUFFALO, N.Y. -- Biomedical researchers at the University ... can grow continuously in culture, a discovery that could ... disease, diabetes, immune disorders and neurodegenerative diseases. , UB ... Universal" by genetically altering mesenchymal stem cells, which ...
... the past three decades, saturated fat has been considered a major ... persists in recommending reduced consumption of this macronutrient. However, new ... impact on CVD risk -- causing many to rethink the "saturated ... articles published in the October issue of Lipids ...
Cached Biology News:Racial differences in breast cancer treatment persist despite similar economics 2Researchers engineer adult stem cells that do not age 2Think saturated fat contributes to heart disease? Think again 2Think saturated fat contributes to heart disease? Think again 3
(Date:10/20/2014)... 2014 Convey Computer , the ... from Iowa State University won first place in the ... Convey HC-2ex, the team’s solution achieved the highest overall ... the second place finisher. , Experts from all segments ... month long challenge, using a variety of design tools, ...
(Date:10/20/2014)... , Oct. 20, 2014  GenVec, Inc. (NASDAQ: ... P. Horovitz , Ph.D., from its board of directors effective ... in August 2003, and served as its chairman from June ... on the Nominating and Corporate Governance and Audit Committees of ... more than a decade of dedicated service to GenVec, and ...
(Date:10/20/2014)... Local veterinary surgeon, Dr. Tim McCarthy is ... donor stem cells for dogs with osteoarthritis. Dr. McCarthy ... performed clinical stem cell therapy for 7 years. The ... a single injection of donor stem cells into one ... and inflammation in the treated joints. , Candidates ...
(Date:10/19/2014)... 2014 The Asia-Pacific Bromine Market ... Asia-Pacific with analysis and forecast of revenue. , ... Bromine Market report, to get an idea of ... glimpse of the segmentation in the Asia-Pacific bromine ... figures. , http://www.micromarketmonitor.com/market/asia-pacific-bromine-6741503144.html , Bromine ...
Breaking Biology Technology:Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 2Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 3Zola P. Horovitz To Retire From GenVec Board 2Cascade Veterinary Referral Center Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 3
... Feb. 3 .decimal, Inc. announced today that,it ... Inc. to supply,patient-specific devices for its proton therapy ... (Logo: http://www.newscom.com/cgi-bin/prnh/20090203/CLTU104LOGO ) , ... have a formal agreement signed with ProCure to ...
... BioMarin Pharmaceutical Inc. (Nasdaq: BMRN ) ... randomized, double-blind, placebo-controlled clinical study of 6R-BH4 in ... There was no statistical significance observed between the ... the study, peak walking time (PWT), did not ...
... Feb. 3 Cardium Therapeutics,(NYSE: CXM ) ... New,England Journal of Medicine showing the long-term outcome of ... a fatal disorder of the immune system.,The infant children ... SCID arises in infants with a genetic defect ...
Cached Biology Technology:ProCure Signs Agreement with .decimal, Inc. to Purchase Patient-Specific Devices for Its Proton Therapy Center in Oklahoma City 2Results From Phase 2 Clinical Study of 6R-BH4 in Peripheral Arterial Disease Not Statistically Significant 2Results From Phase 2 Clinical Study of 6R-BH4 in Peripheral Arterial Disease Not Statistically Significant 3Results From Phase 2 Clinical Study of 6R-BH4 in Peripheral Arterial Disease Not Statistically Significant 4Gene Therapy Field Advances With Important Clinical Findings Reported in the New England Journal of Medicine 2Gene Therapy Field Advances With Important Clinical Findings Reported in the New England Journal of Medicine 3Gene Therapy Field Advances With Important Clinical Findings Reported in the New England Journal of Medicine 4Gene Therapy Field Advances With Important Clinical Findings Reported in the New England Journal of Medicine 5
... /K + ATPase α-1, clone C464.6 ... Immunogen : Purified Na + /K + ... rabbit kidney outer medulla Formulation: 0.1M Tris-glycine, ... azide Quality Assurance: routinely evaluated in immunoblot ...
Purified anti-mouse Tim-1...
Mouse Anti-human CD11b/Mac-1alpha, clone LM2/1, Monoclonal Antibody...
... The epitope is specific for Kir2.1 ... other known protein.,SPECIES REACTIVITIES: The ... bovine, porcine and guinea pig. It ... mouse (17/19 residues) and chick (15/19 ...
Biology Products: