Navigation Links
Regulating the nuclear architecture of the cell

some inheritance, and other processes. Karpen and Peng have identified the molecular pathways that regulate two of heterochromatin's important functions.

One of these is control of repeated DNA sequences in and outside the heterochromatin. The other is the organization and structure of the nucleolus, the ribosome factory, which is situated at the specific site in the heterochromatin where ribosomal DNA -- consisting of large genes, repeated 300 to 400 times -- codes for the production of the RNA from which ribosomes are built.

"This work on pathways that control the organization of the nucleolus is the first to be published that deals with an organelle," says Karpen. "Even though the gross organization of chromosomes and other nuclear elements is well known in cell biology, learning about the regulation of nuclear architecture is in its early stages."

The most striking feature of any nucleus is its chromosomes. These are made of chromatin, which combines DNA with a set of proteins known as histones; four similar histones join together to form a cylindrical spool around which the DNA wraps. Each of these bundles is called a nucleosome, and many nucleosomes are bound together by the continuing strand of DNA, which forms a string of beads that further coils to form one of two kinds of chromatin, either euchromatin or heterochromatin.

Most genes reside in euchromatin, which is of relatively low density and where the DNA is more accessible to the machinery of gene transcription. By contrast, heterochromatin is dense and contains relatively few genes; most of the DNA in heterochromatin, including numerous short repeated sequences, does not code for proteins.

Heterochromatin is typically found at the ends of a chromosome, where it abuts the telomeres -- chromatin structures best known for limiting, by their diminishing length, how many times a cell can replicate. Heterochromatin also flanks the centromere in the cent
'"/>

Source:DOE/Lawrence Berkeley National Laboratory


Page: 1 2 3 4 5

Related biology news :

1. Researchers Discover Gene That Determines Asthma Susceptibility By Regulating Inflammation
2. Researchers solve mystery of how nuclear pores duplicate before cell division
3. First encyclopedia of nuclear receptors reveals organisms focus on sex, food
4. The evolution of food plants: Genetic control of grass flower architecture
5. The very unexpected life and death of a leukemic cell
6. Scientists reveal how disease bacterium survives inside immune system cell
7. Scientists devise way to measure RNA synthesis on the fly in a live cell
8. The making of a fat cell
9. Einstein scientists discover how protein crucial for motion is synthesised at the right place in the cell
10. Researchers identify new cord blood stem cell
11. The molecular post office inside the cell
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Regulating the nuclear architecture the cell

(Date:8/29/2014)... them, fold them: modern materials that are light, flexible ... artificial skin or electronic paper. , Making such concepts ... a new way of working with copper nanowires and ... , Previous success in the field of ultra-lightweight "aerogel ... gold and silver nanowires. , By turning instead ...
(Date:8/28/2014)... America (ESA) is pleased to announce the selection of ... Society. Honorary Membership acknowledges those who have served ESA ... the affairs of the Society that has reached an ... the ESA Governing Board and then voted on by ... the Awards Ceremony at Entomology 2014, ESA,s Annual Meeting ...
(Date:8/28/2014)... available in German . ... its name to a striking pattern of blue stripes alternating ... reflective silvery cells, and yellow cells emerge during growth in ... a multilayered mosaic to compose the characteristic colour pattern. ... have to interact to form proper stripes, the embryonic origin ...
Breaking Biology News(10 mins):Copper shines as flexible conductor 2Fred Baxendale selected as Honorary Member of the Entomological Society of America 2How the zebrafish gets its stripes 2How the zebrafish gets its stripes 3
... front-line defense don’t necessarily rest quietly until invading bacteria ... them to action, as previously thought. In a new ... bacteria can barge inside these guard cells and independently ... published online ahead of print in the April issue ...
... Rothberg of the University of Rochester Chemistry Department received a ... recent discovery by Huixiang Li, a research associate in his ... and make sure we're drinking clean water and eating uncontaminated ... help forensics labs identify criminals, test ponds and pools before ...
... Hypotheses, an Elsevier publication, has announced the winner of ... by Judith Rich-Harris, author of The Nurture Assumption and ... selection process in the evolution of human hairlessness and ... of the journal. The £1,000 prize, launched in 2004, ...
Cached Biology News:Microbes start immune response by sneaking inside cells 2Rapid, Low-Cost DNA Testing 2Rapid, Low-Cost DNA Testing 3Why aren't humans furry? Stone-Age moms could be the answer 2
(Date:8/28/2014)... DIEGO, California, USA (PRWEB) August 28, 2014 ... the Department of Physics and Optical Science and Director ... the University of North Carolina at Charlotte, and co-founder ... been elected to serve as the 2015 Vice President ... , SPIE 2014 President Philip Stahl announced recent election ...
(Date:8/28/2014)... 28, 2014 “This kit has an improved ... from 0 to 150 ppb,” said Mark Tess, PhD, Mycotoxin ... benefit to plant owners and USDA-GIPSA inspection agencies that have ... Testing can take place in a matter of minutes with ... plant test the feed and grain before accepting it, but ...
(Date:8/28/2014)... YORK , Aug. 28, ... that a new market research ... catalogue: Whole Exome ... Kits (Library Preparation, Target Enrichment), ... (Sequencing by Synthesis), by Application ...
(Date:8/28/2014)... SunTrust Robinson Humphrey (STRH) today announced the ... research team in biotechnology and oilfield services.  ... demonstrates our commitment to providing our valued institutional ... decision making," said Biff Woodruff , Head ... significant investments in differentiated content at a time ...
Breaking Biology Technology:Glenn Boreman, UNC Professor and Plasmonics Co-Founder, Elected to SPIE Presidential Chain 2Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 2Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 3Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 4Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 5Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 6Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 7Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 8Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 9Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 10Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 11Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 12Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 13SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 2SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 3
... Biotech Inc. (TSX: ONC, NASDAQ: ONCY ) ... Pandha of the Royal Surrey County Hospital, U.K., was ... Clinical Cancer Research. The paper is entitled "Synergistic Effects ... Melanoma." , The research demonstrated that the innate cancer ...
... , , RICHMOND, Va., Sept. ... fourth year in a row, according to an annual survey published ... brand follows recent No. 1 rankings from Pollina Corporate Real Estate ... rankings by all three of these reputable business brands at one ...
... , , ATLANTA, Sept. 24 ... (the "Company"), an Atlanta-based, biopharmaceutical company developing human vaccines for ... announcement today of partial success in the recently completed Phase ... by Sanofi-Aventis and Global Solutions for Infectious Diseases. The completed ...
Cached Biology Technology:Oncolytics Biotech(R) Inc. Announces Reovirus and Cisplatin Research Supports U.S. Phase 2 Metastatic Melanoma Trial 2Virginia Now Owns Three Top National Business Rankings 2Encouraging HIV/AIDS Vaccine Trial Results Support GeoVax Labs, Inc. Strategy 2Encouraging HIV/AIDS Vaccine Trial Results Support GeoVax Labs, Inc. Strategy 3Encouraging HIV/AIDS Vaccine Trial Results Support GeoVax Labs, Inc. Strategy 4
... ISO 9001:2000 Certified USDA Research Registered ... SOP's Training AALAS Certified Technicians ... Procedures GLP Documentation Upon Request Focus ... point for all your custom immunology service ...
... XL provides balance data collection and automation that ... integration with Microsoft Excel , Pre-configured library ... , New balances can be added and configured ... from multiple balances into one spreadsheet ...
...
... With increasing age, the autofluorescent ... of many cell types, including neurons. ... complicate the use of fluorescence microscopy ... of its broad excitation and emission ...
Biology Products: