Navigation Links
Regenerating worms help elucidate stem cell biology

ne of these genes, called smedwi-2, that was active in dividing neoblasts.

Smedwi-2 belongs to the Argonaute/PIWI protein family and is most similar to PIWI proteins found in fruit flies. According to Sánchez Alvarado, PIWI proteins have been shown to play a role in regulating stem cells in plants and fruit flies, as well as humans. "This encompasses millions of years of evolution," he said. "Still, we don't know exactly how this particular gene is doing its function in any of these organisms."

To find out, the scientists used a technique known as RNA interference to specifically turn off the piwi gene in planaria. When they did this, they found that worms had the same defects as those whose neoblasts have been destroyed by radiation -- head regression, curling, and the inability to regenerate -- suggesting that the gene was needed for normal neoblast function.

The researchers examined piwi's role more closely, and found that when they amputated part of a worm where the gene had been turned off, the stem cells were still able to detect the wound. Amputation triggered the stem cells to divide, as in normal worms, and the daughter cells traveled proficiently to the part of the body where they were needed. However, once they arrived, they failed to replace the lost tissue.

When neoblasts divide, they produce at least two cell types ?one copy of the original, and one cell that can develop into a specialized cell to replace a lost cell elsewhere in the body. The researchers found that without piwi, the daughter cells from this division failed to differentiate into a specialized cell once they'd reached their destination. Based on their findings, Sánchez Alvarado said, "We think that piwi is actually involved in producing daughter cells that are competent to restore aged differentiated cells during homeostasis as well as missing tissues after amputation. Unlike what's been thou
'"/>

Source:Howard Hughes Medical Institute


Page: 1 2 3 4

Related biology news :

1. The secret to longevity in tubeworms
2. Fluorescing lab worms signal longer life spans
3. Deep sea buffet for bone-devouring worms
4. Evolutionary conservation of a mechanism of longevity from worms to mammals
5. Carbon nanotube absorption measured in worms, cancer cells
6. Parasitic worms used to fight bowel disease
7. Scientists elucidate the kinome of key model organism
8. On the track of tiny larvae, a new model elucidates connections in marine ecology
9. Mirrors in the mind: New studies elucidate how the brain reflects onto itself the actions of others
10. Marathon mice elucidate little-known muscle type
11. Insight into DNAs weakest links may yield clues to cancer biology
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Regenerating worms help elucidate stem cell biology

(Date:8/5/2015)... August 5, 2015 According to ... Management Market by Software, Services, Vertical (BFSI, Airport, IT & ... - Global Forecast to 2020", published by MarketsandMarkets, defines ... globally into various segments. The global PIAM Market is ... $546.2 Million by 2019, at a CAGR of 14.9 ...
(Date:8/4/2015)... 2015 Research ... the addition of the "Digital Forensics ... Sub-Segment (Computer Forensics, Network Forensics, Mobile Device ... Vertical and Region - Global Forecast to ... By Component (Hardware, Software, and Service), ...
(Date:7/31/2015)... SHENZHEN , Kina, 31. juli 2015 ... ) bliver afholdt af BGI fra den 22. - 25. ... Konferencen fejrer sin 10-års fødselsdag i år. ... verdens mest indflydelsesrige årlige møder på ,omik,-feltet, og er ... forsamlinger. ICG-10 fokuserer på nylige gennembrud ...
Breaking Biology News(10 mins):Physical Identity and Access Management Market Worth $546.2 Million by 2019 2Physical Identity and Access Management Market Worth $546.2 Million by 2019 3Physical Identity and Access Management Market Worth $546.2 Million by 2019 4Digital Forensics Market - The Market Represents a Compound Annual Growth Rate (CAGR) of 11.3% From 2015 to 2020 2Den 10. internationale konference om Genomics (ICG-10) åbner i oktober 2
... pharmaceutical industry is struggling to deal with bacteria that ... is the similar struggle in agribusiness to deal with ... is widely used in farming practice. The herbicide, ... in Monsanto,s Roundup products and also in herbicides produced ...
... Mich. Sheng Yang He, plant biologist at Michigan ... most-innovative plant scientists as part of a $75 million ... Medical Institute and the Gordon and Betty Moore Foundation ... Laboratory, and 14 other researchers from around the country. ...
... HOUSTON (June 16, 2011) Researchers at The ... have been awarded nearly $1 million to investigate Adenovirus-36 ... The grant is being awarded by the Federal Emergency ... The study will examine the relationship of Ad-36 to ...
Cached Biology News:Scientists learn how horseweed shrugs off herbicide 2Scientists learn how horseweed shrugs off herbicide 3Scientists learn how horseweed shrugs off herbicide 4Scientists learn how horseweed shrugs off herbicide 5MSU plant scientist named one of the nation's most innovative researchers 2UTHealth awarded FEMA grant to explore novel obesity risk factor among firefighters 2UTHealth awarded FEMA grant to explore novel obesity risk factor among firefighters 3
(Date:9/2/2015)... , Sept. 2, 2015 Axovant Sciences Ltd. (NYSE: ... of dementia, today announced upcoming presentations at three investor conferences: ... the Baird 2015 Healthcare Conference in New York ... Thursday, September 10 at 2:00 PM at the BioCentury NewsMakers ... Millennium Broadway Hotel & Conference Center , Thursday, September ...
(Date:9/2/2015)... Research and Markets ... Jain PharmaBiotech,s new report "Biochips and Microarrays ... offering. This report is an analysis ... The report starts with a description of technologies ... include array comparative genomic hybridization (CGH), copy number ...
(Date:9/2/2015)... DUBLIN , Sep. 02, 2015 /PRNewswire/ ... ( http://www.researchandmarkets.com/research/bvxxkf/cytogenetics ) has announced the addition ... - Technologies, Markets and Companies" to ... cytogenetics includes several technologies besides fluorescence in ... and multicolor FISH. Molecular cytogenetics includes application ...
(Date:9/2/2015)... Australian prostate cancer technology company Minomic International ... recognising ,outstanding, science that uses its patented antibody. ... novel prostate cancer diagnostic test known as MiCheck® next ... out the peer-reviewed Australian Museum Eureka Science Prize for ... This prize is awarded for ground breaking research that ...
Breaking Biology Technology:Axovant Sciences To Present At Upcoming Investor Conferences 2Axovant Sciences To Present At Upcoming Investor Conferences 3Global Biochips and Microarrays Technologies, Markets and Companies Report 2015 with Market Size in 2014 and Projected Value for the Years 2019 and 2024 2Global Cytogenetics Technologies Study 2015-2025 - Latest Markets and Companies Analysis 2Global Cytogenetics Technologies Study 2015-2025 - Latest Markets and Companies Analysis 3Prostate Cancer Company Minomic Wins Prestigious Eureka Science Prize 2Prostate Cancer Company Minomic Wins Prestigious Eureka Science Prize 3
... D Garteiz, TexMS Analytical Services, Houston, TX , ... A Varian 1200L LC/MS/MS system was used for ... therapeutic agents to the urinary tract using a urethra suppository mode of ... tract disease is a major health problem in the U.S. and will ...
... , ... Oxidative stress, radiation and other external insults ... diverse as bacteria, yeast, drosophila, rodents and man (Friedberg et al. ... to allow time for DNA repair processes to occur. If however, the system ...
... Ryan Varian Australia Pty. Ltd., Mulgrave, 3170, Victoria, Australia , ... The role of major, minor and trace levels of ... In particular, research on the value of trace elements to the diagnosis, ... The advent of atomic absorption (AA) techniques and the ...
Cached Biology Technology:Quantitation of Oxybutynin in Rabbit Plasma Using the Varian 1200L LC/MS/MS System 2Quantitation of Oxybutynin in Rabbit Plasma Using the Varian 1200L LC/MS/MS System 3DNA Damage and Repair - Quantification of Sub-Cellular Events Using Automated Confocal Imaging 2DNA Damage and Repair - Quantification of Sub-Cellular Events Using Automated Confocal Imaging 3DNA Damage and Repair - Quantification of Sub-Cellular Events Using Automated Confocal Imaging 4DNA Damage and Repair - Quantification of Sub-Cellular Events Using Automated Confocal Imaging 5Analysis of Blood Serum on the Liberty Series II ICP-AES with the axially-viewed plasma 2Analysis of Blood Serum on the Liberty Series II ICP-AES with the axially-viewed plasma 3Analysis of Blood Serum on the Liberty Series II ICP-AES with the axially-viewed plasma 4Analysis of Blood Serum on the Liberty Series II ICP-AES with the axially-viewed plasma 5Analysis of Blood Serum on the Liberty Series II ICP-AES with the axially-viewed plasma 6Analysis of Blood Serum on the Liberty Series II ICP-AES with the axially-viewed plasma 7Analysis of Blood Serum on the Liberty Series II ICP-AES with the axially-viewed plasma 8Analysis of Blood Serum on the Liberty Series II ICP-AES with the axially-viewed plasma 9Analysis of Blood Serum on the Liberty Series II ICP-AES with the axially-viewed plasma 10Analysis of Blood Serum on the Liberty Series II ICP-AES with the axially-viewed plasma 11Analysis of Blood Serum on the Liberty Series II ICP-AES with the axially-viewed plasma 12
...
The PROTEAN II slab gel casting stand is a component of the PROTEAN II XL and xi casting apparatus. It is supplied with gaskets....
BD Falcon insert HTS 96 well, square A-bottom with lid. PET membrane, sterile. (5/ca) Packaging: 5 / pack, 5 / case ...
... a direct antibiotic-based selection system for recombinant ... survival, eliminating the need for costly color ... close to 100% accuracy in recombinant selection. ... robot colony picking. This cloning kit can ...
Biology Products: