Navigation Links
Regenerating worms help elucidate stem cell biology

hey are also responsible for replacing tissue that has been lost naturally. Scientists are just beginning to explore the molecular mechanisms that control adult stem cells, so, said Sánchez Alvarado, it's too soon to know how similar these mechanism are in planaria neoblasts and other organisms' stem cells. "But at least at the gross morphological level and gross biological functions, they compare quite well," he said.

Destruction of a planarian's neoblasts, which occurs when scientists expose the animal to radiation in the laboratory, is devastating. "The animal will survive on the virtue of its differentiated cells," Sánchez Alvarado said, "but as the tissues begin to turn over and there are no stem cells to replace such tissues, the animal begins, basically, to fall apart." It degenerates in a very specific way, he explained, with the tip of the head beginning to regress, followed by a curling up of the sides of the body. Not surprisingly, worms without neoblasts also lose their ability to regenerate.

With their unparalleled capacity for regeneration and the many environmental cues that influence the division and differentiation of their neoblasts, Sánchez Alvarado considers planaria an excellent model to tease out the intricacies of adult stem cell biology. "I think they probably have a lot to teach us about how a population of stem cells is being regulated in vivo, rather than in a Petri dish," he said. So Sánchez Alvarado and his colleagues set out to understand exactly how neoblasts carry out the remarkable maintenance and recreation of the varied tissues that make up a flatworm.

Earlier this year, they got their first clues when they individually turned off 1,065 of the worm's genes, and found 240 that were involved in some aspect of regeneration. Importantly, Sánchez Alvarado noted, 85 percent of these genes are found in the genomes of other organisms, including humans. In the current study, the scientists zeroed in on o
'"/>

Source:Howard Hughes Medical Institute


Page: 1 2 3 4

Related biology news :

1. The secret to longevity in tubeworms
2. Fluorescing lab worms signal longer life spans
3. Deep sea buffet for bone-devouring worms
4. Evolutionary conservation of a mechanism of longevity from worms to mammals
5. Carbon nanotube absorption measured in worms, cancer cells
6. Parasitic worms used to fight bowel disease
7. Scientists elucidate the kinome of key model organism
8. On the track of tiny larvae, a new model elucidates connections in marine ecology
9. Mirrors in the mind: New studies elucidate how the brain reflects onto itself the actions of others
10. Marathon mice elucidate little-known muscle type
11. Insight into DNAs weakest links may yield clues to cancer biology
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Regenerating worms help elucidate stem cell biology

(Date:11/4/2014)... only marketing directed at children on the interior ... that the majority of black, middle-income and rural ... , Authored by Arizona State University researcher Punam ... first to examine the use of child-directed marketing ... restaurants and its relationship to demographics. It adds ...
(Date:11/4/2014)... A majority of Madagascar,s 101 species of lemurs are ... for the rainforests they call home. A new study ... can have on rainforest tree populations, which raises concerns ... the region,s rich biodiversity. , A large proportion of ... Lemurs in turn disperse the seeds of their ...
(Date:11/3/2014)... , Nov. 3, 2014 Research and ... "Cell Therapy - Technologies, Markets and Companies" to ... cell therapy technologies and methods, which have already started to ... stem cell transplantation is replacing the old fashioned bone marrow ... Cell therapy is bound to become a part of medical ...
Breaking Biology News(10 mins):Fast food marketing for children disproportionately affects certain communities 2Fast food marketing for children disproportionately affects certain communities 3Gardeners of Madagascar rainforest at risk 2Gardeners of Madagascar rainforest at risk 3Global Cell Therapy - Technologies, Markets and Companies: 2014 Report 2Global Cell Therapy - Technologies, Markets and Companies: 2014 Report 3
... PHILADELPHIA - Mo Salman, professor of animal population health ... 2010 recipient of the Penn Vet World Leadership Award, ... Veterinary Medicine to a veterinarian who has dramatically ... lives of others. The $100,000 in unrestricted funding, ...
... Scientists are reporting the development and successful initial testing of ... designed to be given as nose drops rather than ... brain cancer, they say. The report appears in ACS, ... and colleagues note that brain cancer is difficult to treat, ...
... Imagine devices that capture electricity from the air much ... light a house or recharge an electric car. Imagine using ... before it forms. Strange as it may sound, scientists already ... to a report at the 240th National Meeting of the ...
Cached Biology News:Penn Vet announces $100,000 winners of 2010 World Leadership Award and Student Inspiration Awards 2Penn Vet announces $100,000 winners of 2010 World Leadership Award and Student Inspiration Awards 3Electricity collected from the air could become the newest alternative energy source 2
(Date:11/15/2014)... York, NY (PRWEB) November 14, 2014 ... plan, QuickSTAT is making significant investments in its ... world of modern cold chain and the complex ... support QuickSTAT’s ongoing focus on customized logistics and ... and enhancement of existing facilities. There will be ...
(Date:11/15/2014)... The "Operating Room Management Market by Product (Data ... operating room Scheduling), by Component (Software, Services), by ... 2019.” defines and segments the operating room management ... by product, such as data management, anesthesia, surgical ... volumes of operating room management market by applications ...
(Date:11/15/2014)... , November 14, 2014 ... has announced the addition of the  "Protein ... & Services, Application, & by End Users ... their offering.  ,     (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ,The ... valued at $1,569.00 million in 2014, and ...
(Date:11/12/2014)... 2014  ReachBio Research Labs (a registered trade name ... announced today that it has signed an agreement with ... giving Funakoshi non-exclusive distribution rights to ReachBio,s human primary ... within Japan . Under a companion ... services to Japanese drug development companies. Photo ...
Breaking Biology Technology:QuickSTAT Announces Global Expansion Plan to Enhance Its Global Network and Cold Chain Logistics Capabilities for Life Sciences 2Operating Room Management Market Worth $4,551.1 Million by 2019 - New Report by MarketsandMarkets 2Operating Room Management Market Worth $4,551.1 Million by 2019 - New Report by MarketsandMarkets 3Operating Room Management Market Worth $4,551.1 Million by 2019 - New Report by MarketsandMarkets 4Global Protein Characterization and Identification (Chromatography, Electrophoresis, Mass Spectroscopy) Market - Forecast to 2019 2Global Protein Characterization and Identification (Chromatography, Electrophoresis, Mass Spectroscopy) Market - Forecast to 2019 3Funakoshi to Distribute ReachBio Research Labs Human Primary Cell Products in Japan 2Funakoshi to Distribute ReachBio Research Labs Human Primary Cell Products in Japan 3
... 11, Bayer HealthCare affiliate MEDRAD, Inc., Warrendale, PA ... ), announced today that,they have entered into a ... Possis Medical in a cash tender offer for ... of approximately US-Dollar 361,million. The offer price represents ...
... a Living ... Cell-Based Therapy, ... to successfully mass-produce living regenerative medicine products,is again breaking new ... living cell-based therapy. As the first,bio-engineered living cell therapy to ...
... Corporation ("AGA"),announced today it received European CE Mark approval ... announced the immediate availability,and launch of the device in ... devices designed to occlude or close a patent ductus ... when a blood vessel,called the ductus arteriosus fails to ...
Cached Biology Technology:Bayer HealthCare Affiliate MEDRAD and Possis Medical Sign Definitive Merger Agreement 2Bayer HealthCare Affiliate MEDRAD and Possis Medical Sign Definitive Merger Agreement 3Bayer HealthCare Affiliate MEDRAD and Possis Medical Sign Definitive Merger Agreement 4Bayer HealthCare Affiliate MEDRAD and Possis Medical Sign Definitive Merger Agreement 5Bayer HealthCare Affiliate MEDRAD and Possis Medical Sign Definitive Merger Agreement 6Organogenesis Debuts Educational Campaign for Sufferers of Chronic Leg and Foot Ulcers 2Organogenesis Debuts Educational Campaign for Sufferers of Chronic Leg and Foot Ulcers 3Organogenesis Debuts Educational Campaign for Sufferers of Chronic Leg and Foot Ulcers 4AGA Medical Corporation Receives European CE Mark Approval for the AMPLATZER(R) Duct Occluder II 2
... Science, which pioneered the blending of thermostable ... and Expand Long Template PCR Systems, now ... the first product of a family ... blend combines Taq DNA Polymerase with a ...
The HEPTEST assays provide a sensitive, simple, rapid, and convenient in vitro quantitation of heparin, low molecular weight heparins, and heparinoids in plasma and whole blood. Sample Type: wh...
...
... Plus DNA Polymerase with a proprietary thermostable ... fidelity than standard Taq DNA polymerase, Double ... Amplifies DNA templates >20kb, Concentration: 5U/ul, Applications: ... cloning and mutagenesis We are part of ...
Biology Products: