Navigation Links
Regenerating worms help elucidate stem cell biology

hey are also responsible for replacing tissue that has been lost naturally. Scientists are just beginning to explore the molecular mechanisms that control adult stem cells, so, said Sánchez Alvarado, it's too soon to know how similar these mechanism are in planaria neoblasts and other organisms' stem cells. "But at least at the gross morphological level and gross biological functions, they compare quite well," he said.

Destruction of a planarian's neoblasts, which occurs when scientists expose the animal to radiation in the laboratory, is devastating. "The animal will survive on the virtue of its differentiated cells," Sánchez Alvarado said, "but as the tissues begin to turn over and there are no stem cells to replace such tissues, the animal begins, basically, to fall apart." It degenerates in a very specific way, he explained, with the tip of the head beginning to regress, followed by a curling up of the sides of the body. Not surprisingly, worms without neoblasts also lose their ability to regenerate.

With their unparalleled capacity for regeneration and the many environmental cues that influence the division and differentiation of their neoblasts, Sánchez Alvarado considers planaria an excellent model to tease out the intricacies of adult stem cell biology. "I think they probably have a lot to teach us about how a population of stem cells is being regulated in vivo, rather than in a Petri dish," he said. So Sánchez Alvarado and his colleagues set out to understand exactly how neoblasts carry out the remarkable maintenance and recreation of the varied tissues that make up a flatworm.

Earlier this year, they got their first clues when they individually turned off 1,065 of the worm's genes, and found 240 that were involved in some aspect of regeneration. Importantly, Sánchez Alvarado noted, 85 percent of these genes are found in the genomes of other organisms, including humans. In the current study, the scientists zeroed in on o
'"/>

Source:Howard Hughes Medical Institute


Page: 1 2 3 4

Related biology news :

1. The secret to longevity in tubeworms
2. Fluorescing lab worms signal longer life spans
3. Deep sea buffet for bone-devouring worms
4. Evolutionary conservation of a mechanism of longevity from worms to mammals
5. Carbon nanotube absorption measured in worms, cancer cells
6. Parasitic worms used to fight bowel disease
7. Scientists elucidate the kinome of key model organism
8. On the track of tiny larvae, a new model elucidates connections in marine ecology
9. Mirrors in the mind: New studies elucidate how the brain reflects onto itself the actions of others
10. Marathon mice elucidate little-known muscle type
11. Insight into DNAs weakest links may yield clues to cancer biology
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Regenerating worms help elucidate stem cell biology

(Date:10/17/2014)... in German . ... drugs. When treating overdoses, doctors are often limited to supportive ... there is a combination of drugs involved. So what can ... his grandmother,s pills? ETH professor Jean-Christophe Leroux from the Institute ... answer to this question. "The task was to develop an ...
(Date:10/16/2014)... cultivated efficiently, they are anything but sustainable: environmental ... cultivation is becoming increasingly evident. Despite their disadvantages, ... are regarded as the sole possibility of achieving ... finds Bernhard Schmid, an ecology professor at the ... of agriculture and forestry. After all, a new ...
(Date:10/15/2014)... our ability to assess the pandemic risk from strains ... we must not allow ourselves to become complacent that ... international consortium of scientists. , Influenza pandemics arise when ... yet to develop widespread immunity – spreads in the ... the past 100 years, the worst of which – ...
Breaking Biology News(10 mins):Emergency aid for overdoses 2Emergency aid for overdoses 3Plant communities produce greater yield than monocultures 2Plant communities produce greater yield than monocultures 3Scientists 'must not become complacent' when assessing pandemic threat from flu viruses 2
... The 2010 Annual Meeting & OTO EXPO of the American ... the largest meeting of ear, nose, and throat doctors in ... official abstract supplement for the annual meeting is now available ... Otolaryngology Head and Neck Surgery . (See new ...
... a genetic route to understanding and treating epilepsy. Timothy ... has identified an ancient gene family that plays a role ... "In healthy people, nerves do not fire excessively in response ... on what really matters. Nerve cells maintain a threshold ...
... Eliza Hall Institute researchers in Melbourne, Australia, have made ... cell death and its role in tumour formation. ... process in human biology as it removes unwanted and ... against cancer development and autoimmune disease. The ...
Cached Biology News:Otolaryngology -- Head and Neck Surgery Annual Meeting supplement now available 2Epileptic seizures may be linked to an ancient gene family 2Missing Puma reveals cancer conundrum 2Missing Puma reveals cancer conundrum 3
(Date:10/18/2014)... (PRWEB) October 19, 2014 The ... (Short Acting, Intermediate Acting, Premixed), Modern Human Insulin ... Apidra, Levemir, NovoRapid, Novomix, Tresiba, Others) - Forecast ... major drivers, restraints, challenges, opportunities, current market trends, ... along with the estimates and forecasts of the ...
(Date:10/18/2014)... The Asian arthroscopic devices report defines and segments the ... revenue. The arthroscopic devices market in Asia is estimated ... CAGR of 6.5% from 2013 to 2018. , Browse ... to get an idea of the in-depth analysis provided. ... arthroscopic devices market in the same region, and is ...
(Date:10/18/2014)... The Asian Electronic Medical Record (EMR) market ... analysis and forecast of revenue. The electronic medical record market ... million by 2018, at a CAGR of 9.4% from 2013 ... Electronic Medical Record (EMR) market, to get an idea of ... the segmentation of the market in the same region, and ...
(Date:10/18/2014)... The report " Cloud Analytics ... Web; Speech; Machine; Video; Predictive Analytics: Global Advancements, ... & Analysis (2013 - 2018) ", defines and ... sub segments with an in-depth analysis and forecasting ... factors driving this market, various restraints, and opportunities ...
Breaking Biology Technology:Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 2Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 3Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 4Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 5The Asian arthroscopic devices market is estimated to grow to $712.3 million by 2018 - New Report by MicroMarket Monitor 2The Asian arthroscopic devices market is estimated to grow to $712.3 million by 2018 - New Report by MicroMarket Monitor 3The Asian arthroscopic devices market is estimated to grow to $712.3 million by 2018 - New Report by MicroMarket Monitor 4The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 2The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 3The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 4The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 5Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 2Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 3Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 4Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 5
... in ... ... CHDX ) a leading independent American provider of Western,healthcare services ... has agreed to an investment by JPMorgan,s Principal,Investment Management group. The ...
... Nov. 7 Transgenomic Inc. (OTC,Bulletin Board: TBIO) announces the following Webcast: ... Conference Call, ... Where: http://www.transgenomic.com/events.asp?id=6 , How: ... at the ...
... - Nventa,Biopharmaceuticals Corporation (TSX: NVN) announced today financial results,for ... unless,specified otherwise, are in Canadian dollars. Nventa reported ... share, for the,three months ended September 30, 2007, compared ... share, for the same period in 2006. For the ...
Cached Biology Technology:JPMorgan's Principal Investment Management Group to Invest in Chindex International, Inc. 2JPMorgan's Principal Investment Management Group to Invest in Chindex International, Inc. 3Webcast Alert: Transgenomic Inc. Announces Third Quarter 2007 Earnings Release Conference Call Webcast 2Nventa Biopharmaceuticals Corporation announces third-quarter 2007 financial results 2Nventa Biopharmaceuticals Corporation announces third-quarter 2007 financial results 3Nventa Biopharmaceuticals Corporation announces third-quarter 2007 financial results 4
... (ELISA) test kits are qualitative one-step kits ... of drugs and/or their metabolites in forensic ... use only. It is recommended that all ... method such as GC/MS. The simple ...
96 Well Base Plate...
... a recombinant human protein produced in E. coli ... RNase A type enzymes. The mode of ... in a 1:1 ratio. The enzyme has been ... and cell types. Addition of the ribonuclease inhibitor ...
... Inkjet Printer) is a revolutionary new ... Protein Macroarray Analysis, developed in conjunction ... strategy compliments established protocols in resolving ... proteins isoelectric point and apparent molecular ...
Biology Products: