Navigation Links
Reducing antibiotic use lowers rates of drug-resistant bacteria

Fewer antibiotic prescriptions leads to fewer "superbugs." That's the take-home message behind a new study in the Oct. 15 issue of Clinical Infectious Diseases, now available online. The study found that reducing antibiotic use for pediatric respiratory tract infections resulted in lower rates of carriage of drug-resistant bacteria.

Drug-resistant bacteria, commonly called "superbugs," are fast becoming a problem due to overuse and inappropriate prescribing of antibiotics. Streptococcus pneumoniae bacteria, also called pneumococci, are commonly found in children's noses and throats, and can result in ear infections, sinusitis, pneumonia and even meningitis. Many pneumococcal infections are treated with penicillin, but resistance to the drug is making the microbes more difficult to control.

Researchers in France tested two intervention methods intended to reduce the rate of carriage of penicillin-resistant pneumococci in kindergarteners. The prescription-reduction method involved not prescribing antibiotics for respiratory tract infections that were thought to be viral, since antibiotics work against bacteria, not viruses. The dose/duration method involved using only recommended doses of antibiotics for no longer than 5 days. The researchers also targeted physicians, pharmacists, parents, and children in the groups receiving both interventions with an information campaign about antibiotic resistance and appropriate antibiotic use. A control group of children and their doctors received no specific information about antibiotic use.

The study was conducted from January through May of 2000. By the end of the study, antibiotic use had declined by more than 15 percent in both intervention groups, compared to less than 4 percent in the control group. Although colonization by regular pneumococci was higher in the intervention groups than in the control group, colonization by penicillin-resistant pneumococci was lower in the intervention groups than i n the control group. The prescription-reduction group saw the greatest decline in penicillin-resistant colonization (from 53 percent to 35 percent), and the dose/duration group dropped from 55 percent to 44 percent. The control group remained nearly unchanged. This suggests that reduced antibiotic pressure allows drug-susceptible bacteria to re-establish themselves as dominant colonizers of the respiratory tract.

Implementing intervention programs that are "focused on populations most exposed to antibiotics"--that is, children--is the first step in reining in superbugs, said lead author Didier Guillemot, MD, PhD, of Institut Pasteur.

Intervention methods such as reducing the number of prescriptions and, when ordered, the dose and duration of antibiotics, "can induce significant and rapid reductions" of penicillin-resistant pneumococcal colonization in areas that have high rates of drug-resistant bacteria, according to the study. In essence, doctors can make their own jobs easier by prescribing antibiotics more judiciously, thus slowing the spread of superbugs.


Source:Infectious Diseases Society of America

Related biology news :

1. Reducing malarial transmission in Africa
2. Researchers make gains in understanding antibiotic resistance
3. Measuring hormone cuts antibiotic use in half in pneumonia patients
4. New book explains antibiotic resistance for a broad audience
5. Research on antibiotics receives historical recognition
6. Unusual antibiotics show promise against deadly superbugs
7. Doctors should stop prescribing antibiotics for the common cold, review advises
8. Gaining ground in the race against antibiotic resistance
9. Researchers find how some antibiotics kill bacteria
10. Einstein researchers identify new way that bacteria develop resistance to antibiotics
11. Agricultural antibiotic use contributes to super-bugs in humans
Post Your Comments:

(Date:6/9/2016)... an innovation leader in attendance control systems is proud to announce the introduction of ... make sure the right employees are actually signing in, and to even control the ... ... ... ...
(Date:6/7/2016)... , June 7, 2016  Syngrafii Inc. ... a business relationship that includes integrating Syngrafii,s patented ... branch project. This collaboration will result in greater ... the credit union, while maintaining existing document workflow ... ...
(Date:6/2/2016)... June 2, 2016 The Department of ... awarded the 44 million US Dollar project, for the ... Plates including Personalization, Enrolment, and IT Infrastructure , ... the production and implementation of Identity Management Solutions. Numerous renowned ... Decatur was selected for the most ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... Mass. , June 23, 2016   ... development of novel compounds designed to target cancer ... napabucasin, has been granted Orphan Drug Designation from ... the treatment of gastric cancer, including gastroesophageal junction ... stemness inhibitor designed to inhibit cancer stemness pathways ...
(Date:6/23/2016)... ... June 23, 2016 , ... Charm Sciences, Inc. is pleased ... received AOAC Research Institute approval 061601. , “This is another AOAC-RI approval of ... Salter, Vice President of Regulatory and Industrial Affairs. “The Peel Plate methods perform ...
(Date:6/23/2016)... ... 2016 , ... Supplyframe, the Industry Network for electronics hardware ... . Located in Pasadena, Calif., the Design Lab’s mission is to bring together ... built and brought to market. , The Design Lab is Supplyframe’s physical representation ...
(Date:6/23/2016)... June 23, 2016  Blueprint Bio, a company dedicated ... the medical community, has closed its Series A funding ... . "We have received a commitment from ... we need to meet our current goals," stated ... the runway to complete validation on the current projects ...
Breaking Biology Technology: