Navigation Links
Red flag for repetitive stress injuries identified for first time in humans

For the first time in humans, scientists have found early indicators of inflammation ?potential warning signs ?in work-related injuries caused by repetitive motion.

Their findings could someday lead to early detection and prevention of debilitating conditions such as carpal tunnel syndrome and tendonitis.

The new study from Temple University senior researchers Ann Barr and Mary Barbe and their doctoral student, Stephen Carp, in the March issue of Clinical Science, found that the immune system pumps out biomarkers (different kinds of chemicals) as the body begins to become injured by repetitive motions. These biomarkers warn of an underlying problem.

"While not a diagnostic test, because the biomarkers could also indicate another type of injury, they do provide a red flag where before there was none," said Barr, associate professor of physical therapy at Temple's College of Health Professions.

Currently, healthcare providers can diagnose repetitive motion injuries (RMI) based only on physical examination findings and the symptoms reported by the patient.

Typically, RMI sufferers don't experience symptoms of pain until the damage has begun. So the researchers' main goal has been finding a means to detect the problem before the damage starts. That way, conservative intervention ?ibuprofen, rest breaks at work, exercise ?can be evaluated as to their effectiveness in preventing the development of chronic work-related conditions and, consequently, the need for more serious measures such as surgery.

"If the injury to the tissues can be halted, then hopefully long-term damage and impairment can be avoided," said Barbe, also an associate professor of physical therapy.

Employers and workers know the dramatic impact of RMIs, which cause pain, loss of function and close to a third of missed workdays in the United States, at a cost of $20 billion a year in workers' compensation.

In previous studies, the researchers pinpointed these early warning signals in a rat model of RMI. The current study is the first to identify the warning signals in humans.

For the study, they recruited 22 participants who were suffering from repetitive-stress injuries, including carpal tunnel syndrome, tendonitis, and other wrist and shoulder injuries, and nine healthy subjects. After a physical examination that rated the severity of symptoms ranging from pain to range of motion, participants were given blood tests for evidence of biomarkers.

"The blood tests revealed significant levels of several types of inflammatory mediators ?biomarkers ?which signaled an underlying problem," said Barr. "Also, the more severe the injury, the more biomarkers there were."

Future research by the team will look deeper into the potential of biomarkers as indicators of injury and recovery.


'"/>

Source:Temple University


Related biology news :

1. A little stress gives beneficial oomph! to immune system
2. Immune systems distress signal tells bacteria when to strike back
3. Scientists discover the bodys marijuana-like compounds are crucial for stress-induced pain relief
4. Endocannabinoids ?the brains cannabis ?demonstrate novel modes of action to stress
5. Penguin chicks exposed to human visitors experience spike in stress hormone
6. Researchers unravel DNA tangles and enzyme seamstresses
7. Key stress protein linked to toxicities responsible for Parkinsons, Alzheimers
8. Just like us, social stress prompts hamsters to overeat, gain weight
9. Newborn screening can cause unnecessary parental stress
10. Adults who go to bed lonely get stress hormone boost next morning
11. Coral stress like never in history
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/22/2016)... 2016  The American College of Medical Genetics and Genomics ... as one of the fastest-growing trade shows during the ... Bellagio in Las Vegas . ... growth in each of the following categories: net square feet ... of attendees. The 2015 ACMG Annual Meeting was ranked 23 ...
(Date:6/21/2016)... VANCOUVER, British Columbia , June 21, 2016 ... been appointed to the new role of principal ... has been named the director of customer development. ... , NuData,s chief technical officer. The moves reflect ... development teams in response to high customer demand ...
(Date:6/15/2016)... 2016 Transparency Market Research ... Market by Application Market - Global Industry Analysis Size Share ... the report, the  global gesture recognition market  was ... is estimated to grow at a CAGR of ... Increasing application of gesture recognition technology ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... Parallel 6 , ... announced today the Clinical Reach Virtual Patient Encounter CONSULT module which enables ... the physician and clinical trial team. , Using the CONSULT module, patients and physicians ...
(Date:6/24/2016)... 2016  Regular discussions on a range of subjects including ... two entities said Poloz. Speaking at a lecture ... , he pointed to the country,s inflation target, which is ... "In certain areas there ... common economic goals, why not sit down and address strategy ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... to announce the launch of their brand, UP4™ Probiotics, into Target stores nationwide. ... years, is proud to add Target to its list of well-respected retailers. This ...
(Date:6/23/2016)... ... June 23, 2016 , ... Charm Sciences, Inc. ... test has received AOAC Research Institute approval 061601. , “This is another AOAC-RI ... stated Bob Salter, Vice President of Regulatory and Industrial Affairs. “The Peel Plate ...
Breaking Biology Technology: