Navigation Links
Red flag for repetitive stress injuries identified for first time in humans

For the first time in humans, scientists have found early indicators of inflammation ?potential warning signs ?in work-related injuries caused by repetitive motion.

Their findings could someday lead to early detection and prevention of debilitating conditions such as carpal tunnel syndrome and tendonitis.

The new study from Temple University senior researchers Ann Barr and Mary Barbe and their doctoral student, Stephen Carp, in the March issue of Clinical Science, found that the immune system pumps out biomarkers (different kinds of chemicals) as the body begins to become injured by repetitive motions. These biomarkers warn of an underlying problem.

"While not a diagnostic test, because the biomarkers could also indicate another type of injury, they do provide a red flag where before there was none," said Barr, associate professor of physical therapy at Temple's College of Health Professions.

Currently, healthcare providers can diagnose repetitive motion injuries (RMI) based only on physical examination findings and the symptoms reported by the patient.

Typically, RMI sufferers don't experience symptoms of pain until the damage has begun. So the researchers' main goal has been finding a means to detect the problem before the damage starts. That way, conservative intervention ?ibuprofen, rest breaks at work, exercise ?can be evaluated as to their effectiveness in preventing the development of chronic work-related conditions and, consequently, the need for more serious measures such as surgery.

"If the injury to the tissues can be halted, then hopefully long-term damage and impairment can be avoided," said Barbe, also an associate professor of physical therapy.

Employers and workers know the dramatic impact of RMIs, which cause pain, loss of function and close to a third of missed workdays in the United States, at a cost of $20 billion a year in workers' compensation.

In previous studies, the researchers pinpointed these early warning signals in a rat model of RMI. The current study is the first to identify the warning signals in humans.

For the study, they recruited 22 participants who were suffering from repetitive-stress injuries, including carpal tunnel syndrome, tendonitis, and other wrist and shoulder injuries, and nine healthy subjects. After a physical examination that rated the severity of symptoms ranging from pain to range of motion, participants were given blood tests for evidence of biomarkers.

"The blood tests revealed significant levels of several types of inflammatory mediators ?biomarkers ?which signaled an underlying problem," said Barr. "Also, the more severe the injury, the more biomarkers there were."

Future research by the team will look deeper into the potential of biomarkers as indicators of injury and recovery.


Source:Temple University

Related biology news :

1. A little stress gives beneficial oomph! to immune system
2. Immune systems distress signal tells bacteria when to strike back
3. Scientists discover the bodys marijuana-like compounds are crucial for stress-induced pain relief
4. Endocannabinoids ?the brains cannabis ?demonstrate novel modes of action to stress
5. Penguin chicks exposed to human visitors experience spike in stress hormone
6. Researchers unravel DNA tangles and enzyme seamstresses
7. Key stress protein linked to toxicities responsible for Parkinsons, Alzheimers
8. Just like us, social stress prompts hamsters to overeat, gain weight
9. Newborn screening can cause unnecessary parental stress
10. Adults who go to bed lonely get stress hormone boost next morning
11. Coral stress like never in history
Post Your Comments:

(Date:4/28/2016)... India , April 28, 2016 ... Infosys (NYSE: INFY ), and Samsung SDS, a ... that will provide end customers with a more secure, ... services.      (Logo: ) , ... services, but it also plays a fundamental part in enabling ...
(Date:4/26/2016)... India and LONDON ... Infosys Finacle, part of EdgeVerve Systems, a product ... and Onegini today announced a partnership to integrate ... solutions.      (Logo: ... to provide their customers enhanced security to access ...
(Date:4/19/2016)... April 20, 2016 The new ... a compact web-based "all-in-one" system solution for all door ... reader or the door interface with integration authorization management ... control systems. The minimal dimensions of the access control ... the building installations offer considerable freedom of design with ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... ... 24, 2016 , ... Researchers at the Universita Politecnica delle Marche in Ancona ... or pleural mesothelioma. Their findings are the subject of a new article on the ... are signposts in the blood, lung fluid or tissue of mesothelioma patients that can ...
(Date:6/23/2016)... Mass. , June 23, 2016   ... development of novel compounds designed to target cancer ... napabucasin, has been granted Orphan Drug Designation from ... the treatment of gastric cancer, including gastroesophageal junction ... stemness inhibitor designed to inhibit cancer stemness pathways ...
(Date:6/23/2016)... 23, 2016 Houston Methodist Willowbrook Hospital ... Sports Association to serve as their official health ... Methodist Willowbrook will provide sponsorship support, athletic training ... association coaches, volunteers, athletes and families. ... Sports Association and to bring Houston Methodist quality ...
(Date:6/23/2016)... NEW YORK , June, 23, 2016  The ... students to envision new ways to harness living systems ... of Modern Art (MoMA) in New York ... more than 130 participating students, showcased projects at MoMA,s ... included Paola Antonelli , MoMA,s senior curator of ...
Breaking Biology Technology: