Navigation Links
Reactivated gene shrinks tumors

Many cancers arise due to defects in genes that normally suppress tumor growth. Now, for the first time, MIT researchers have shown that re-activating one of those genes in mice can cause tumors to shrink or disappear.

The study offers evidence that the tumor suppressor gene p53 is a promising target for human cancer drugs.

"If we can find drugs that restore p53 function in human tumors in which this pathway is blocked, they may be effective cancer treatments," said David Kirsch of MIT's Center for Cancer Research and Harvard Medical School, one of the lead co-authors of the paper.

The study will be published in the Jan. 24 online edition of Nature. It was conducted in the laboratory of Tyler Jacks, director of the Center for Cancer Research, the David H. Koch Professor of Biology and a Howard Hughes Medical Institute investigator.

P53 has long been known to play a critical role in the development of many tumors-it is mutated in more than 50 percent of human cancers. Researchers have identified a few compounds that restore p53 function, but until now, it has not been known whether such activity would actually reverse tumor growth in primary tumors.

The new MIT study shows that re-activating p53 in mouse tumors dramatically reduces the size of the tumors, in some cases by 100 percent.

"This study provides critical genetic evidence that continuous repression of a tumor suppressor gene is required for a tumor to survive," said Andrea Ventura, an Italian postdoctoral associate in the Center for Cancer Research and first author of the paper.

In normal cells, p53 controls the cell cycle. In other words, when functioning properly, it activates DNA repair mechanisms and prevents cells with damaged DNA from dividing. If DNA damage is irreparable, p53 induces the cell to destroy itself by undergoing apoptosis, or programmed cell death.

When p53 is turned off by mutation or deletion, cells are much
'"/>

Source:Massachusetts Institute of Technology


Page: 1 2 3

Related biology news :

1. Ultrasounds show mothers drinking shrinks fetal brain
2. Overfishing large sharks impacts entire marine ecosystem, shrinks shellfish supply
3. Pulsating ultrasound enhances gene therapy for tumors
4. A new link between stem cells and tumors
5. Prostate cancer uses Wnt signaling proteins to promote growth of bone tumors
6. Double trouble: Cells with duplicate genomes can trigger tumors
7. Common molecular signature identified in solid tumors
8. Virus chip detects new virus in prostate tumors
9. Macrophage signaling may affect hormone resistance in prostate tumors
10. Common molecular signature identified in solid tumors
11. Vegetables inhibit growth of prostate cancer in mice with human tumors
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Reactivated gene shrinks tumors

(Date:2/5/2015)... DIEGO , Jan. 26, 2015   Epic Sciences ... of cancer, today announced that Murali Prahalad , Ph.D., ... Personalized Medicine World Conference (PMWC) 2015: Silicon Valley, which ... Mountain View, Calif. on January 26-28, 2015. ... "CTCs Come of Age as Biomarkers." Last year, Epic Sciences ...
(Date:2/5/2015)... 28, 2015 NXT-ID, Inc. (NASDAQ: ... biometric authentication company focused on the growing mobile commerce ... Global Online CEO Conference on January 29 th ... Pereira , CEO of NXT-ID will present and host ... Wocket smart wallet and its full suite of biometric ...
(Date:1/22/2015)... Research and Markets ( http://www.researchandmarkets.com/research/4trb7t/biometrics_a ) has announced ... Overview" report to their offering. , ... an individual is who she/he is claiming to be, and ... person,s unique physical characteristics, such as fingerprint, hand or palm ...
Breaking Biology News(10 mins):Epic Sciences to Present at Personalized Medicine World Conference 2015 on the Use of Circulating Tumor Cells as Cancer Biomarkers 2CEO of NXT-ID, Inc. to Discuss Company's Biometric Technologies at RedChip Online Conference January 29th 2CEO of NXT-ID, Inc. to Discuss Company's Biometric Technologies at RedChip Online Conference January 29th 3Biometrics - A Global Market Overview 2Biometrics - A Global Market Overview 3
... SuviCa Inc. of Boulder and the University of Colorado ... drug screening technology to identify novel therapies for cancer. ... CU-Boulder Associate Professor Tin Tin Su of the molecular, ... Drosophila fruit fly model to screen for compounds effective ...
... our understanding of genetics and biological processes in all animals, ... of animals, scientists are still finding the fruit fly to ... the University of Rochester. The latest revelation has to ... fruit flies. It was widely accepted that all X chromosomes ...
... than 250 leading scientists from around the world will ... address how science can contribute to solving some of ... be attached to the approval of the organization,s Strategic ... establishment of a major new ten-year programme of earth ...
Cached Biology News:SuviCa Inc. of Boulder to commercialize CU-Boulder cancer screening technology 2New thinking on regulation of sex chromosomes in fruit flies 2Global science community to gather in Rome 2
(Date:2/26/2015)...   Synageva BioPharma Corp. (NASDAQ: ... products for rare disorders, today reported 2014 full ... key objectives, and financial guidance.  Synageva,s management team ... p.m. EST to review the financial results and ... today,s call by telephone, please dial (877) 445-4603 ...
(Date:2/26/2015)... Fla. , Feb. 26, 2015 DuPont ... growth priorities driven by key research advancements and product ... at today,s Bank of America Merrill Lynch 2015 Global ... the challenge of building grain supplies the last two ... continue at the pace of the last decade, when ...
(Date:2/26/2015)... Calif. , Feb. 26, 2015  NuGene ... age-defying aesthetic products for skin and hair rejuvenation, ... Relations as agency of record for investor relations ... to improve our distribution, sales and diversification strategies ... to current and prospective shareholders," stated Ali Kharazmi ...
(Date:2/26/2015)... February 26, 2015 The Pittcon ... at the Ernest N. Morial Convention Center in ... as of February 19, 2015) displaying products and ... academic, and government labs. The Exposition will offer ... not limited to, analytical chemistry; drug discovery; nanotechnology; ...
Breaking Biology Technology:Synageva BioPharma Reports 2014 Full Year Financial Results 2Synageva BioPharma Reports 2014 Full Year Financial Results 3Synageva BioPharma Reports 2014 Full Year Financial Results 4Synageva BioPharma Reports 2014 Full Year Financial Results 5Synageva BioPharma Reports 2014 Full Year Financial Results 6Synageva BioPharma Reports 2014 Full Year Financial Results 7Synageva BioPharma Reports 2014 Full Year Financial Results 8Synageva BioPharma Reports 2014 Full Year Financial Results 9DuPont Leader Outlines Path for Growth in Agriculture and Nutrition & Health Segments 2DuPont Leader Outlines Path for Growth in Agriculture and Nutrition & Health Segments 3DuPont Leader Outlines Path for Growth in Agriculture and Nutrition & Health Segments 4DuPont Leader Outlines Path for Growth in Agriculture and Nutrition & Health Segments 5NuGene International, Inc. Selects Capital Market Relations for Strategic Investor Relations 2NuGene International, Inc. Selects Capital Market Relations for Strategic Investor Relations 3Pittcon 2015 Announces Exposition Highlights 2
... Feb. 1, 2012  Generex Biotechnology Corporation (OTCBB: GNBT.OB) ... Express, Inc., has been awarded a Japanese Patent ... of immunotherapeutic vaccines.  A number of products developed ... The patent helps to secure the novel Antigen ...
... 1, 2012 The report " ... Global Trends, Opportunities & Forecasts (2011   -   2020) ... the major market drivers, restraints, and opportunities in North America, ... Browse market data tables and in-depth TOC on the ...
... is subjected to gravity. Some biological systems require gravity for ... the absence of gravity even human biology is affected: astronauts ... usual 1-2% a year on Earth. But the effects of ... published in BioMed Central,s open access journal BMC Genomics ...
Cached Biology Technology:Generex Announces Patent Award for its Core Vaccine Technologies in Japan 2Generex Announces Patent Award for its Core Vaccine Technologies in Japan 3Generex Announces Patent Award for its Core Vaccine Technologies in Japan 4MarketsandMarkets: Global Biomarkers Market worth $25.79 Billion by 2016 2MarketsandMarkets: Global Biomarkers Market worth $25.79 Billion by 2016 3Weightlessness weighs heavy on genes a fly's perspective 2
This BioSolution package is excellent for doing fluorescence thermal melt experiments on nucleic acids, studies involving biomolecular interactions, protein folding experiments, and more!...
... Probes Fc OxyBURST Green reagent (F-2902) was ... Boston University to permit measurement of the ... the subsequent oxidative burst directly in the ... consists of bovine serum albumin (BSA) that ...
... BAC (100+kb), fosmid (40kb), and large plasmid ... any othe BAC vector. On command 20-50 ... easy recombinant DNA purification. Available with blue-white ... vectors for the highest insert stability. Kits ...
Designed for flow cytometric applications intended to identify...
Biology Products: