Navigation Links
Radiation-killed bacteria vaccine induces broad immune response in mice

Vaccines made with bacteria killed by gamma irradiation, rather than by standard methods of heat or chemical inactivation, may be more effective, say researchers supported by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH). Vaccines made from gamma-irradiated bacteria also may not need to be kept cold; an advantage in settings where refrigerating vaccines is impractical or impossible. A report on the research appears in the current issue of the journal Immunity.

In experiments with mice, scientists including Eyal Raz, M.D., Sandip Datta, M.D., and Joshua Fierer, M.D., of the University of California, San Diego, School of Medicine demonstrated that a vaccine made from irradiated Listeria monocytogenes bacteria, unlike a vaccine made from heat-killed bacteria, provides protection against challenge with live Listeria. The irradiated bacteria also stimulated a protective response from immune system cells called T cells. Previously, only vaccines made from live, weakened Listeria bacteria were believed capable of eliciting a T-cell response.

"This advance is potentially of great importance in meeting the challenge of creating vaccines that are safe, effective and simple to manufacture and transport," says NIH Director Elias A. Zerhouni, M.D.

Ideally, vaccines should stimulate a strong response not only from both arms of the adaptive immune system (antibodies and T cells), but also the body's innate immune system. However, traditional ways of making vaccines--either by killing disease-causing agents with heat, chemicals or by weakening (attenuating) live pathogens--have characteristic shortcomings. For example, heat- and chemical-killed vaccines, while safe and relatively easy to produce, generally produce a less broad immune response than live, attenuated vaccines. Conversely, it can be difficult to create live, attenuated vaccines that safely preserve the pathogen's abi
'"/>

Source:NIH/National Institute of Allergy and Infectious Diseases


Page: 1 2 3

Related biology news :

1. Anti-bacterial additive widespread in U.S. waterways
2. A bacterial genome reveals new targets to combat infectious disease
3. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
4. Scientists discover that host cell lipids facilitate bacterial movement
5. Family trees of ancient bacteria reveal evolutionary moves
6. Drug-resistant bacteria on poultry products differ by brand
7. Programmable cells: Engineer turns bacteria into living computers
8. NASA links nanobacteria to kidney stones and other diseases
9. Substance protects resilient staph bacteria
10. Physiological effects of reduced gravity on bacteria
11. Anammox bacteria produce nitrogen gas in oceans snackbar
Post Your Comments:
(Date:11/21/2014)... Strict laws against distracted driving and the ... American and European automotive sector towards gesture recognition technologies. ... that are intuitive and able to retrieve information with ... New analysis from Frost & Sullivan,s Strategic ... Europe and North America ...
(Date:11/21/2014)... SAN JOSE, Calif. , Nov. 20, 2014 /PRNewswire/ ... a global leader in microcontroller (MCU) and touch technology ... digital temperature sensors with the widest V ... family delivers higher temperature accuracy and faster I 2 ... nonvolatile registers and serial EEPROM memory making them ideal ...
(Date:11/18/2014)... 17, 2014   News Highlights: ... to develop The Partners Data Lake, an agile ... Data Lake will allow researcher and clinicians to ... and the lives of patients , The ... activities across the Partners system, breaking down physical ...
Breaking Biology News(10 mins):Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 2Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 4Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 2Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 3Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 3Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 5
... CSIRO researchers, in collaboration with the International Maize ... the research illustrates the major genetic improvements possible ... often use wild relatives of wheat as sources ... research team leader Dr Phil Larkin says. ...
... Growth hormone treatments work better on some children than on ... in height is no simple task. Now researchers have developed ... growth hormone to treat children who are abnormally short for ... the online open access journal BMC Medical Informatics and Decision ...
... the University of Southern California (USC) suggest epigenetics, or the ... cause for male infertility. The study will be published in ... This is the first report based on our ... semen development, says Rebecca Sokol, M.D., MPH, professor of obstetrics ...
Cached Biology News:Building disease-beating wheat 2USC researchers explore genetic causes for male infertility 2
(Date:12/24/2014)... AUSTIN, Texas , Dec. 23, 2014 /PRNewswire/ ... solutions company focused on gynecologic disease, announced today ... W. Schuler , Birchview Fund LLC and several ... million of unregistered shares of Vermillion,s common stock ... common stock in a private placement.  ...
(Date:12/22/2014)... December 22, 2014 The Center ... leader of technical training across the life sciences industry, ... Management (SCDM) to provide the organization's members with ... —providing access to the more than 350 sessions across ... with 10% off when registering for a public ...
(Date:12/22/2014)... Calif. , Dec. 22, 2014  ( www.competitivehealth.com ... CoPatient, an online medical bill review and advocacy service, ... in the FREE WellCard Savings discount health services marketplace. ... bill that was more than they expected to pay. ... reduce health care costs, WellCard Savings is pleased to ...
(Date:12/19/2014)... Charm Sciences is pleased to announce ... of Aflatoxin M1 in raw commingled milk is the ... validation. The peer reviewed report of the validation by ... Agricultural and Fisheries Research (ILVO-T&V) has been published by ... the most toxic aflatoxin and a known carcinogen, can ...
Breaking Biology Technology:Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 2Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 3Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 4Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 5CfPIE Announces Partnership with the Society for Clinical Data Management 2CfPIE Announces Partnership with the Society for Clinical Data Management 3WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Charm Sciences Achieves Independent Validation of First 15 Minute Quantitative Screening Method for Aflatoxin M1 2
... free Importance of Mixing webinar will compare lab mixing and large ... Reinaldo M. Machado entitled "Fundamentals of Scale-up" and "iControl Mixing Guidelines". ... ... METTLER TOLEDO invites you to view a free on-demand webinar ...
... Cytopia Limited (ASX: CYT) announced that it will present ... at the forthcoming 100th Annual Meeting of the American ... David Segal, Principal Scientist at Cytopia, will be presenting ... Molecular Therapeutics 2 poster session on Tuesday, April ...
... China, April 15 /PRNewswire-Asia-FirstCall/ -- China Sky One,Medical, Inc. ... CSKI ), a,leading fully integrated pharmaceutical company producing ... announced that it will,conduct a conference call at 10:00 ... to discuss its fourth quarter and fiscal year 2008,financial ...
Cached Biology Technology:The Importance of Mixing: How to Compare Lab Scale Mixing with Full Scale Process Vessel Performance 2Cytopia Presentation on VDA CYT997 at AACR Conference 2China Sky One Medical, Inc. Announces Conference Call to Discuss Fourth Quarter and Fiscal Year 2008 Results 2
... Nonanoyl-N-methylglucamide White ... Can be readily removed by dialysis. ... Purity: ≥98% by HPLC. Absorbance ... 2 O. CMC 19 - ...
...
Mouse polyclonal antibody to TNPO2 - transportin 2 (importin 3, karyopherin beta 2b)...
... polyclonal to HDAC4 - ChIP Grade ... II mammalian histone deacetylases, which consists of ... is highly similar to the deacetylase domain ... shuttles between the nucleus and cytoplasm in ...
Biology Products: