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RNA map provides first comprehensive understanding of alternative splicing

work lays out an approach to developing a global understanding of how alternative splicing is regulated by one disease-associated protein, Nova, offering a route by which scientists may now be able to approach a number of diseases with a fresh start."

Finally, Darnell's work has shown that Nova is expressed in certain types of cancer cells. Cancer cells operate by dysregulating gene expression, and Darnell believes that further studies are needed to determine whether Nova is a cause of dysregulated gene expression at the level of alternative splicing in a cancer cell.

"The right splicing factor in the wrong environment could wreck havoc and change the quality of proteins in a tumor cell," he says.
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Source:Rockefeller University


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... I from E. coli is ... enzyme also contains both 5'--3'and ... exonuclease activity enables the enzyme ... in the DNA as starting ...
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... of the human Topoisomerase II gene. ... state of nucleic acids by passing an intact ... a separate DNA helix (1,2) . As a ... enzyme can relax negatively or positively supercoiled DNA, ...
... Exonuclease-free Klenow Fragment is a genetically engineered Klenow ... activity has been removed, leaving only the 5 ... activity makes Exo- Klenow Fragment the enzyme of ... probes by the random primed method, and for ...
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